ZNF385A and MIR1-1

Number of citations of the paper that reports this interaction (PubMedID 28431233)
0

Data Source:
BioGRID (unspecified method)

		ZNF385A	MIR1-1
Description		zinc finger protein 385A	microRNA 1-1
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Nucleolus Cytoplasm Cytosol Dendrite Cell Projection Neuronal Cell Body	Extracellular Space RISC Complex
	Molecular Function	P53 Binding Nucleic Acid Binding DNA Binding RNA Binding MRNA 3'-UTR Binding Zinc Ion Binding Metal Ion Binding	MRNA 3'-UTR Binding MRNA Base-pairing Post-transcriptional Repressor Activity
	Biological Process	Regulation Of Translation Apoptotic Process DNA Damage Response Hemostasis Learning Or Memory Locomotory Behavior Intracellular MRNA Localization MRNA Localization Resulting In Post-transcriptional Regulation Of Gene Expression Platelet Formation Megakaryocyte Development Positive Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator Positive Regulation Of Fat Cell Differentiation Platelet Alpha Granule Organization Negative Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator Regulation Of Cytoplasmic Translation	Positive Regulation Of Cell Fate Commitment Positive Regulation Of Heart Rate Negative Regulation Of Cardiac Muscle Hypertrophy Positive Regulation Of Myotube Differentiation Regulation Of Release Of Sequestered Calcium Ion Into Cytosol By Sarcoplasmic Reticulum Regulation Of Cardiac Muscle Contraction By Regulation Of The Release Of Sequestered Calcium Ion Negative Regulation Of Cell Migration MiRNA-mediated Post-transcriptional Gene Silencing MiRNA-mediated Gene Silencing By Inhibition Of Translation MiRNA-mediated Gene Silencing By MRNA Destabilization Negative Regulation Of Fibroblast Growth Factor Receptor Signaling Pathway Negative Regulation Of Insulin-like Growth Factor Receptor Signaling Pathway Negative Regulation Of Endothelial Cell Differentiation Negative Regulation Of Lipid Biosynthetic Process Regulation Of Cardiac Muscle Contraction Negative Regulation Of Cardiac Muscle Cell Proliferation Positive Regulation Of Sarcomere Organization Regulation Of Ventricular Cardiac Muscle Cell Membrane Depolarization Ventricular Septum Morphogenesis Positive Regulation Of Cardiac Muscle Contraction Cell Migration Involved In Coronary Vasculogenesis Positive Regulation Of Adenylate Cyclase-activating Adrenergic Receptor Signaling Pathway Negative Regulation Of Canonical Wnt Signaling Pathway Reversible Differentiation Negative Regulation Of Intracellular Signal Transduction Positive Regulation Of Sprouting Angiogenesis Negative Regulation Of Cardiac Conduction Negative Regulation Of Vascular Associated Smooth Muscle Cell Proliferation Positive Regulation Of Calcium Ion Transmembrane Transport Via High Voltage-gated Calcium Channel Regulation Of Membrane Repolarization During Ventricular Cardiac Muscle Cell Action Potential Negative Regulation Of Membrane Repolarization During Cardiac Muscle Cell Action Potential Positive Regulation Of Vascular Associated Smooth Muscle Cell Apoptotic Process Negative Regulation Of Xenobiotic Detoxification By Transmembrane Export Across The Plasma Membrane Positive Regulation Of Mesoderm Formation Negative Regulation Of Calcium Ion Export Across Plasma Membrane Positive Regulation Of Cardiac Vascular Smooth Muscle Cell Differentiation Positive Regulation Of Cardiac Muscle Cell Differentiation Negative Regulation Of Myoblast Proliferation Positive Regulation Of Skeletal Muscle Cell Differentiation
Pathways		TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest Regulation of TP53 Activity through Association with Co-factors Transcriptional activation of cell cycle inhibitor p21
Drugs
Diseases
GWAS		Waist circumference adjusted for body mass index ( 34021172) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)	Prostate cancer ( 23535732) Subjective response to lithium treatment in bipolar disorder ( 26503763)
Interacting Genes		10 interacting genes: MIR1-1 MIR155 MIR19A MIR19B1 MIR19B2 MIR34C MIR9-1 MIR9-2 MIR9-3 OGT	89 interacting genes: ADARB1 APOBEC3B AQR ATXN2L C1QBP CPSF7 CRTAP DARS1 DDX1 DDX21 DDX3X DHX36 DHX37 EDC4 EIF2AK2 EPRS1 ERAL1 FUS G3BP2 HNRNPA0 HNRNPA1 HNRNPA2B1 HNRNPA3 HNRNPF HNRNPH1 HNRNPH2 HNRNPH3 HNRNPK HNRNPL HNRNPM HNRNPR IARS1 IGF2BP1 IGF2BP2 IGF2BP3 KARS1 KIN KNOP1 LARP7 LARS1 LIN28A LIN28B LRPPRC MARS1 MATR3 MSI2 NOL6 NONO NUDT21 NUFIP2 PDCD11 PRMT1 PTBP1 PTBP3 PUF60 PUM1 PURA QARS1 RARS1 RBFOX2 RBM14 RBM4 RTCA RTCB SART3 SF3B1 SF3B2 SF3B3 SF3B4 SFPQ SPOUT1 STRBP SUGP1 SUGP2 SYNCRIP TAF15 TRA2A TRA2B TRIM25 TRIM71 U2SURP UPF1 UTP20 YBX1 YBX2 YBX3 ZFR ZNF346 ZNF385A
Entrez ID		25946	406904
HPRD ID		16448
Ensembl ID		ENSG00000161642	ENSG00000199017
Uniprot IDs		Q96PM9
PDB IDs
Enriched GO Terms of Interacting Partners?		MiRNA-mediated Post-transcriptional Gene Silencing Regulatory NcRNA-mediated Post-transcriptional Gene Silencing Post-transcriptional Gene Silencing Regulatory NcRNA-mediated Gene Silencing RISC Complex Post-transcriptional Regulation Of Gene Expression MRNA Base-pairing Post-transcriptional Repressor Activity Negative Regulation Of Gene Expression Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Biosynthetic Process MiRNA-mediated Gene Silencing By MRNA Destabilization Negative Regulation Of Macromolecule Metabolic Process MRNA 3'-UTR Binding Negative Regulation Of Metabolic Process Negative Regulation Of Extracellular Matrix Assembly Regulation Of Cardiac Muscle Hypertrophy MRNA Destabilization Regulation Of Extracellular Matrix Assembly RNA Destabilization Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of Extracellular Matrix Organization Positive Regulation Of MRNA Catabolic Process Negative Regulation Of Cell Migration Regulation Of Cellular Response To Growth Factor Stimulus Negative Regulation Of Cell Motility Negative Regulation Of Locomotion Positive Regulation Of MRNA Metabolic Process Positive Regulation Of Cardiac Muscle Hypertrophy Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Negative Regulation Of Xenobiotic Detoxification By Transmembrane Export Across The Plasma Membrane Negative Regulation Of Response To Drug Negative Regulation Of Cardiac Epithelial To Mesenchymal Transition Positive Regulation Of Striated Muscle Cell Differentiation Regulation Of Gene Expression Negative Regulation Of Translation Regulation Of Macromolecule Biosynthetic Process MiRNA-mediated Gene Silencing By Inhibition Of Translation Regulation Of MRNA Stability Regulation Of Sprouting Angiogenesis Regulation Of RNA Stability Negative Regulation Of Matrix Metallopeptidase Secretion Negative Regulation Of Developmental Process Positive Regulation Of Cell Growth Involved In Cardiac Muscle Cell Development Regulation Of Heart Growth Regulation Of Extracellular Matrix Organization Regulation Of Response To Drug Regulation Of Muscle System Process Positive Regulation Of Muscle Cell Differentiation Regulation Of Macromolecule Metabolic Process	RNA Binding Nucleic Acid Binding RNA Processing RNA Metabolic Process Nucleic Acid Metabolic Process MRNA Metabolic Process RNA Splicing MRNA Processing Nucleobase-containing Compound Metabolic Process MRNA Binding Regulation Of MRNA Metabolic Process Macromolecule Metabolic Process Nucleoplasm Nucleus MRNA Splicing, Via Spliceosome Post-transcriptional Regulation Of Gene Expression RNA Splicing, Via Transesterification Reactions Regulation Of RNA Splicing Cytoplasmic Stress Granule Spliceosomal Complex Regulation Of Translation MiRNA Binding Aminoacyl-tRNA Synthetase Multienzyme Complex Ribonucleoprotein Complex Catalytic Step 2 Spliceosome MRNA 3'-UTR Binding Negative Regulation Of MRNA Metabolic Process Regulation Of MRNA Processing Regulation Of MRNA Splicing, Via Spliceosome Negative Regulation Of Translation Negative Regulation Of RNA Catabolic Process Regulation Of Gene Expression Regulation Of RNA Stability Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of MRNA Catabolic Process RNA Stabilization Regulation Of Primary Metabolic Process TRNA Aminoacylation For Protein Translation Aminoacyl-tRNA Ligase Activity Regulation Of MRNA Stability Regulation Of Macromolecule Metabolic Process Ligase Activity TRNA Aminoacylation Nucleolus MRNA Stabilization P-body Negative Regulation Of Macromolecule Metabolic Process Positive Regulation Of Cytoplasmic Translation Regulation Of Cytoplasmic Translation Regulation Of Metabolic Process
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