FAM13B and AGTR1

Number of citations of the paper that reports this interaction (PubMedID 28298427)
90

Data Source:
BioGRID (two hybrid)

		FAM13B	AGTR1
Description		family with sequence similarity 13 member B	angiotensin II receptor type 1
Image		No pdb structure
GO Annotations	Cellular Component	Cytosol	Plasma Membrane Membrane
	Molecular Function	GTPase Activator Activity	Angiotensin Type I Receptor Activity G Protein-coupled Receptor Activity Angiotensin Type II Receptor Activity Protein Binding Bradykinin Receptor Binding Protein Heterodimerization Activity
	Biological Process	Signal Transduction Regulation Of Small GTPase Mediated Signal Transduction	Regulation Of Cell Growth Kidney Development Renin-angiotensin Regulation Of Aldosterone Production Maintenance Of Blood Vessel Diameter Homeostasis By Renin-angiotensin Regulation Of Systemic Arterial Blood Pressure By Renin-angiotensin Inflammatory Response Signal Transduction G Protein-coupled Receptor Signaling Pathway Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Rho Protein Signal Transduction Positive Regulation Of Macrophage Derived Foam Cell Differentiation Regulation Of Vasoconstriction Calcium-mediated Signaling Low-density Lipoprotein Particle Remodeling Regulation Of Renal Sodium Excretion Angiotensin-activated Signaling Pathway Regulation Of Cell Population Proliferation Symbiont Entry Into Host Cell Regulation Of Inflammatory Response Positive Regulation Of Inflammatory Response Cell Chemotaxis Phospholipase C-activating Angiotensin-activated Signaling Pathway Positive Regulation Of Cholesterol Metabolic Process Blood Vessel Diameter Maintenance Positive Regulation Of Blood Vessel Endothelial Cell Proliferation Involved In Sprouting Angiogenesis Positive Regulation Of Reactive Oxygen Species Metabolic Process
Pathways		CDC42 GTPase cycle RAC1 GTPase cycle	Peptide ligand-binding receptors G alpha (q) signalling events Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis
Drugs			Valsartan Olmesartan Losartan Candesartan cilexetil Eprosartan Telmisartan Irbesartan Forasartan Saprisartan Tasosartan CYT006-AngQb Azilsartan medoxomil Fimasartan Angiotensin II Candesartan
Diseases			Renal tubular dysgenesis
GWAS		Atrial fibrillation ( 28416818 29892015 30061737) Autism spectrum disorder or schizophrenia ( 28540026) Plateletcrit ( 32888494)	Birth weight ( 31043758) Chin dimples ( 27182965) Height ( 31562340) Lead levels in blood ( 25820613) Monobrow ( 27182965) Type 2 diabetes ( 31049640)
Interacting Genes		8 interacting genes: AGTR1 CDC42 LINC00839 RAC1 SAMHD1 YWHAE YWHAG YWHAZ	77 interacting genes: ABI3 ACE2 ADD3 AGT AGTRAP AP2M1 ARFGAP1 ARHGDIG ARRB1 ARRB2 ATP13A1 ATP1B1 BAALC BASP1 BDKRB2 BNIP3 BRD8 CBR1 CCDC25 CD37 CERS6 CUEDC2 DBNDD2 DNAJC14 DNAJC8 EGFR FAM13B FBXW11 FNBP1 GHITM GNA12 GOT1 GPAA1 GPRASP1 GRK2 GRK3 GRK5 HDGFL2 HHATL HRAS JAK1 JAK2 JKAMP KIAA0930 LCNL1 LLGL1 LZTS1 NACAD NDRG2 NOS3 NPTN NUP88 OAZ1 PCMT1 PDE6H PLCG1 PLCH2 PNMA1 PPP1R3F PSMD10 PTGFR RAB5A RAF1 RBSN RTN3 SAE1 SCG5 SELENOF SERINC3 SLC16A1 SPG21 THOP1 TMEM161A TMEM80 UBR4 UGT8 YWHAQ
Entrez ID		51306	185
HPRD ID		06464	00107
Ensembl ID		ENSG00000031003	ENSG00000144891
Uniprot IDs		A0A2X0SG06 A0A8I5KSB9 Q9NYF5	A0A0A0MSE3 D3DNG8 P30556 Q53YY0 Q6NUP5
PDB IDs			4YAY 4ZUD 6DO1 6OS0 6OS1 6OS2
Enriched GO Terms of Interacting Partners?		Focal Adhesion Protein Sequestering Activity Phosphoserine Residue Binding G Protein-coupled Receptor Signaling Pathway Involved In Heart Process Establishment Of Golgi Localization Thioesterase Binding Melanosome Golgi Localization Intracellular Signaling Cassette Angiotensin-activated Signaling Pathway GTP-dependent Protein Binding Intracellular Signal Transduction Positive Regulation Of Lamellipodium Assembly Phagocytosis, Engulfment Negative Regulation Of Immune System Process Positive Regulation Of Lamellipodium Organization Wnt Signaling Pathway, Planar Cell Polarity Pathway Protein Targeting Negative Regulation Of Immune Response Regulation Of Lamellipodium Assembly Protein Domain Specific Binding Positive Regulation Of Substrate Adhesion-dependent Cell Spreading Substantia Nigra Development Membrane Invagination Regulation Of Cell Communication Small GTPase-mediated Signal Transduction Regulation Of Signaling Positive Regulation Of Stress Fiber Assembly Regulation Of Lamellipodium Organization Non-canonical Wnt Signaling Pathway Cellular Response To Glucose Starvation Angiotensin Type I Receptor Activity Neural Nucleus Development Regulation Of Substrate Adhesion-dependent Cell Spreading Regulation Of Synapse Organization Positive Regulation Of Actin Filament Bundle Assembly Negative Regulation Of TORC1 Signaling TORC1 Signaling DGTPase Activity DGTP Binding Triphosphoric Monoester Hydrolase Activity Deoxynucleoside Triphosphate Hydrolase Activity Regulation Of Defense Response G Protein Activity Regulation Of Immune System Process GTP Binding Cell Migration Bradykinin Receptor Binding Intracellular Protein Localization Cytoplasmic Ribonucleoprotein Granule	Negative Adaptation Of Signaling Pathway Desensitization Of G Protein-coupled Receptor Signaling Pathway Beta-adrenergic Receptor Kinase Activity Regulation Of G Protein-coupled Receptor Signaling Pathway Receptor Internalization Type 1 Angiotensin Receptor Binding G Protein-coupled Receptor Binding G Protein-coupled Receptor Kinase Activity Negative Regulation Of G Protein-coupled Receptor Signaling Pathway Receptor-mediated Endocytosis Regulation Of Cell Communication Regulation Of Signaling Angiotensin Receptor Binding Endocytic Vesicle Membrane Membrane Type II Interferon-mediated Signaling Pathway Regulation Of Apoptotic Process Regulation Of Apoptotic Signaling Pathway Regulation Of Programmed Cell Death Regulation Of Signal Transduction Intracellular Signaling Cassette Regulation Of Biological Quality Regulation Of Muscle System Process Regulation Of Protein Modification Process Negative Regulation Of Smooth Muscle Cell Proliferation Regulation Of Blood Circulation Postsynaptic Density Negative Regulation Of Signal Transduction Establishment Of Protein Localization Phosphatidylinositol-4,5-bisphosphate Phospholipase C Activity Endocytosis Regulation Of MAPK Cascade Regulation Of Vasoconstriction Regulation Of Long-term Neuronal Synaptic Plasticity Regulation Of Systemic Arterial Blood Pressure Mediated By A Chemical Signal Positive Regulation Of Receptor Internalization Regulation Of The Force Of Heart Contraction By Chemical Signal Positive Regulation Of Gap Junction Assembly Interferon-mediated Signaling Pathway Plasma Membrane Clathrin-coated Pit Protein Transport Negative Regulation Of Cell Communication Negative Regulation Of Signaling Regulation Of Protein Phosphorylation Cytoplasm ERBB Signaling Pathway Import Into Cell Negative Regulation Of Apoptotic Process Tachykinin Receptor Signaling Pathway
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?