MS4A6A

Description		membrane spanning 4-domains A6A
Image		No pdb structure
GO Annotations	Cellular Component	Trans-Golgi Network Plasma Membrane Membrane
	Molecular Function	Protein Binding
	Biological Process	Cell Surface Receptor Signaling Pathway
Pathways
Drugs
Diseases
GWAS		Alzheimer's disease ( 21460840) Alzheimer's disease (late onset) ( 24162737 28714976 30617256) Alzheimer's disease in APOE e4- carriers ( 25778476) Alzheimer's disease or family history of Alzheimer's disease ( 30617256) C-reactive protein levels ( 30388399) Cerebrospinal fluid sTREM-2 levels ( 31708768) Factor VII activity ( 30642921) Factor VII activity or levels ( 30642921) Family history of Alzheimer's disease ( 30617256) Fibrinogen ( 23969696) Fibrinogen levels ( 26561523 28107422) Gut microbiota (bacterial taxa, hurdle binary method) ( 32572223) Heel bone mineral density ( 30598549 28869591) Lymphocyte percentage of white cells ( 32888494) Methadone dose in opioid dependence ( 28115739) Neutrophil count ( 32888494) White matter hyperintensity volume x hypertension interaction (2df) ( 33293549)
Novel Interacting Genes		1 novel interacting genes: ZDHHC5
Interacting Genes		1 interacting genes: GPRC5D
Entrez ID		64231
HPRD ID		09414
Ensembl ID		ENSG00000110077
Uniprot IDs		B4DUN6 E9PSA9 Q9H2W1
PDB IDs
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Protein Localization To Phagocytic Vesicle Postsynaptic Specialization, Intracellular Component Nucleotide-binding Oligomerization Domain Containing 1 Signaling Pathway Positive Regulation Of Pyroptotic Inflammatory Response Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Protein Palmitoylation Palmitoyltransferase Activity Nucleotide-binding Oligomerization Domain Containing 2 Signaling Pathway Pyroptotic Cell Death NLRP3 Inflammasome Complex Assembly Response To Muramyl Dipeptide Protein-cysteine S-palmitoyltransferase Activity Protein Lipidation Canonical Inflammasome Complex Assembly Positive Regulation Of NLRP3 Inflammasome Complex Assembly Pyroptotic Inflammatory Response Protein Kinase Activator Activity Regulation Of NLRP3 Inflammasome Complex Assembly
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