DTX4

Description		deltex E3 ubiquitin ligase 4
Image		No pdb structure
GO Annotations	Cellular Component	Nucleoplasm Cytoplasm Centrosome Cytosol
	Molecular Function	Ubiquitin-protein Transferase Activity Zinc Ion Binding Transferase Activity Metal Ion Binding Ubiquitin Protein Ligase Activity
	Biological Process	Notch Signaling Pathway Proteasomal Protein Catabolic Process Protein Ubiquitination Regulation Of Type I Interferon Production Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Innate Immune Response Negative Regulation Of Innate Immune Response Protein K48-linked Ubiquitination Antiviral Innate Immune Response
Pathways		IRF3 mediated activation of type 1 IFN Activated NOTCH1 Transmits Signal to the Nucleus Activated NOTCH1 Transmits Signal to the Nucleus Regulation of innate immune responses to cytosolic DNA IRF3-mediated induction of type I IFN
Drugs
Diseases
GWAS		Hepatitis B surface antigen seroclearance in chronic hepatitis B infection ( 29975729) Metabolite levels ( 23823483)
Novel Interacting Genes		1 novel interacting genes: ZDHHC5
Interacting Genes
Entrez ID		23220
HPRD ID		19312
Ensembl ID		ENSG00000110042
Uniprot IDs		Q9Y2E6
PDB IDs
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Protein Localization To Phagocytic Vesicle Postsynaptic Specialization, Intracellular Component Nucleotide-binding Oligomerization Domain Containing 1 Signaling Pathway Positive Regulation Of Pyroptotic Inflammatory Response Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Protein Palmitoylation Palmitoyltransferase Activity Nucleotide-binding Oligomerization Domain Containing 2 Signaling Pathway Pyroptotic Cell Death NLRP3 Inflammasome Complex Assembly Response To Muramyl Dipeptide Protein-cysteine S-palmitoyltransferase Activity Protein Lipidation Canonical Inflammasome Complex Assembly Positive Regulation Of NLRP3 Inflammasome Complex Assembly Pyroptotic Inflammatory Response Regulation Of NLRP3 Inflammasome Complex Assembly Positive Regulation Of Pattern Recognition Receptor Signaling Pathway Regulation Of Postsynaptic Membrane Neurotransmitter Receptor Levels Positive Regulation Of Protein Localization To Plasma Membrane Protein K63-linked Ubiquitination Positive Regulation Of Protein Localization To Cell Periphery Fatty Acid Transport Positive Regulation Of Protein Localization To Membrane Phagocytic Vesicle GABA-ergic Synapse Cytoplasmic Pattern Recognition Receptor Signaling Pathway Regulation Of Protein Localization To Plasma Membrane Monocarboxylic Acid Transport Acyltransferase Activity Regulation Of Protein Localization To Cell Periphery Pattern Recognition Receptor Signaling Pathway Regulation Of Protein Localization To Membrane Positive Regulation Of Inflammatory Response Innate Immune Response-activating Signaling Pathway Protein Localization To Plasma Membrane Positive Regulation Of Protein-containing Complex Assembly Activation Of Innate Immune Response Protein Localization To Cell Periphery Postsynapse Intracellular Receptor Signaling Pathway
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