MPC2 and MICOS10

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		MPC2	MICOS10
Description		mitochondrial pyruvate carrier 2	mitochondrial contact site and cristae organizing system subunit 10
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Mitochondrion Mitochondrial Inner Membrane Membrane Inner Mitochondrial Membrane Protein Complex	SAM Complex Mitochondrion Mitochondrial Inner Membrane Membrane Mitochondrial Crista Junction MICOS Complex MIB Complex
	Molecular Function	Protein Binding Identical Protein Binding Pyruvate Transmembrane Transporter Activity	Protein Binding
	Biological Process	Pyruvate Decarboxylation To Acetyl-CoA Pyruvate Import Into Mitochondria Positive Regulation Of Insulin Secretion Involved In Cellular Response To Glucose Stimulus	Inner Mitochondrial Membrane Organization Cristae Formation
Pathways		Pyruvate metabolism	Cristae formation
Drugs
Diseases
GWAS
Interacting Genes		12 interacting genes: APOC1 CIDEB DIABLO MICOS10 NEAT1 RHBDD2 RPLP1 SNX1 SPG21 SYT16 TEX44 TIMM17B	4 interacting genes: APOC2 APOC4 CIDEB MPC2
Entrez ID		25874	440574
HPRD ID		08525	18824
Ensembl ID		ENSG00000143158	ENSG00000173436
Uniprot IDs		O95563	A0A087WU07 Q5TGZ0
PDB IDs		8YW6 8YW8 8YW9 9KNW 9KNX 9KNY 9MNW 9MNX 9MNY 9MNZ 9MO0
Enriched GO Terms of Interacting Partners?		Very-low-density Lipoprotein Particle Assembly Protein-lipid Complex Assembly Plasma Lipoprotein Particle Assembly Regulation Of Triglyceride Metabolic Process Negative Regulation Of Phosphatidylcholine Catabolic Process	Acylglycerol Homeostasis High-density Lipoprotein Particle Lipid Transport Very-low-density Lipoprotein Particle Triglyceride Homeostasis Regulation Of Triglyceride Metabolic Process Lipid Storage Positive Regulation Of Very-low-density Lipoprotein Particle Remodeling Pyruvate Import Into Mitochondria Lipid Homeostasis Negative Regulation Of Very-low-density Lipoprotein Particle Clearance Chylomicron Remodeling Positive Regulation Of Phospholipid Catabolic Process Chylomicron Remnant Clearance Triglyceride-rich Lipoprotein Particle Clearance Intermediate-density Lipoprotein Particle Lipoprotein Lipase Activator Activity Pyruvate Transmembrane Transport Pyruvate Transmembrane Transporter Activity Inner Mitochondrial Membrane Protein Complex Lipid Droplet Fusion Spherical High-density Lipoprotein Particle Positive Regulation Of Triglyceride Catabolic Process Regulation Of Phospholipid Catabolic Process Lipase Inhibitor Activity Very-low-density Lipoprotein Particle Remodeling High-density Lipoprotein Particle Clearance Pyruvate Transport Import Into The Mitochondrion Pyruvate Decarboxylation To Acetyl-CoA Regulation Of Lipid Metabolic Process Triglyceride-rich Lipoprotein Particle Remodeling Phospholipase Activator Activity Very-low-density Lipoprotein Particle Assembly Lipoprotein Catabolic Process Chylomicron Phospholipid Efflux Lipid Transfer Activity Acetyl-CoA Biosynthetic Process COPI-coated Vesicle Low-density Lipoprotein Particle COPII Vesicle Coat Reverse Cholesterol Transport Identical Protein Binding Negative Regulation Of Lipoprotein Particle Clearance COPII-coated Vesicle Cargo Loading Phospholipase Binding Negative Regulation Of Cholesterol Transport Mitochondrial Transmembrane Transport Positive Regulation Of Triglyceride Metabolic Process
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