MPC2 and NEAT1

Number of citations of the paper that reports this interaction (PubMedID 32140098)
39

Data Source:
BioGRID (unspecified method)

		MPC2	NEAT1
Description		mitochondrial pyruvate carrier 2	nuclear paraspeckle assembly transcript 1
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Mitochondrion Mitochondrial Inner Membrane Membrane Inner Mitochondrial Membrane Protein Complex	RISC Complex Paraspeckles
	Molecular Function	Protein Binding Identical Protein Binding Pyruvate Transmembrane Transporter Activity	MiRNA Binding Chromatin-protein Adaptor Activity Molecular Condensate Scaffold Activity MiRNA Inhibitor Activity Via Base-pairing RISC Complex Binding
	Biological Process	Pyruvate Decarboxylation To Acetyl-CoA Pyruvate Import Into Mitochondria Positive Regulation Of Insulin Secretion Involved In Cellular Response To Glucose Stimulus	LncRNA-mediated Post-transcriptional Gene Silencing Chromatin Organization Regulation Of MRNA Export From Nucleus Nuclear Body Organization MiRNA-mediated Post-transcriptional Gene Silencing Positive Regulation Of Inflammatory Response Positive Regulation Of Synoviocyte Proliferation Positive Regulation Of MiRNA Catabolic Process
Pathways		Pyruvate metabolism
Drugs
Diseases
GWAS			Acne (severe) ( 24927181) Glaucoma (primary open-angle) ( 29891935) Hip circumference adjusted for BMI ( 34021172) Hip index ( 34021172)
Interacting Genes		12 interacting genes: APOC1 CIDEB DIABLO MICOS10 NEAT1 RHBDD2 RPLP1 SNX1 SPG21 SYT16 TEX44 TIMM17B	12 interacting genes: CTSD EGR1 GAR1 HACD3 MPC2 NEDD4L PINK1 RIMBP2 TRAF6 TUBB4A TUBB4B USP9X
Entrez ID		25874	283131
HPRD ID		08525
Ensembl ID		ENSG00000143158	ENSG00000245532
Uniprot IDs		O95563
PDB IDs		8YW6 8YW8 8YW9 9KNW 9KNX 9KNY 9MNW 9MNX 9MNY 9MNZ 9MO0
Enriched GO Terms of Interacting Partners?		Very-low-density Lipoprotein Particle Assembly Protein-lipid Complex Assembly Plasma Lipoprotein Particle Assembly Regulation Of Triglyceride Metabolic Process Negative Regulation Of Phosphatidylcholine Catabolic Process	Receptor Metabolic Process Protein Kinase B Binding Antigen Processing And Presentation Of Peptide Or Polysaccharide Antigen Via MHC Class II Antigen Processing And Presentation Of Peptide Antigen Via MHC Class II Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Receptor Recycling Regulation Of Protein Localization Interleukin-1-mediated Signaling Pathway Positive Regulation Of Post-translational Protein Modification Mitochondrial Transport Antigen Processing And Presentation Of Exogenous Peptide Antigen Organelle Organization Antigen Processing And Presentation Of Exogenous Antigen Positive Regulation Of Glomerular Metanephric Mesangial Cell Proliferation Regulation Of Biological Quality Regulation Of Post-translational Protein Modification Cellular Response To Interleukin-8 Protein Ubiquitination K11-linked Deubiquitinase Activity Canonical NF-kappaB Signal Transduction Antigen Processing And Presentation Of Peptide Antigen Insulin Catabolic Process Aspartic-type Peptidase Activity Autophagosome Organization Cysteine-type Endopeptidase Activity Antigen Processing And Presentation Autophagosome Assembly Insulin Receptor Recycling Positive Regulation Of Protein Metabolic Process Hemi-methylated DNA-binding Enzyme Binding Positive Regulation Of Protein Modification Process Cellular Response To Mycophenolic Acid Circadian Temperature Homeostasis Glomerular Mesangial Cell Proliferation Cellular Response To Heparin Regulation Of Progesterone Biosynthetic Process Response To Ischemia BMP Signaling Pathway Regulation Of Protein Metabolic Process Protein K48-linked Ubiquitination Protein Modification By Small Protein Conjugation Post-translational Protein Modification Positive Regulation Of Protein Ubiquitination Regulation Of Protein Catabolic Process Regulation Of Protein Stability Structural Constituent Of Cytoskeleton Internode Region Of Axon Intercellular Bridge Negative Regulation Of Sodium Ion Import Across Plasma Membrane
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