RASGRP3 and DYNC2LI1

		RASGRP3	DYNC2LI1
Description		RAS guanyl releasing protein 3	dynein cytoplasmic 2 light intermediate chain 1
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Plasma Membrane Guanyl-nucleotide Exchange Factor Complex Perinuclear Region Of Cytoplasm	Cytoplasm Golgi Apparatus Centrosome Cytosol Cytoskeleton Cytoplasmic Dynein Complex Microtubule Cytoplasmic Microtubule Cilium Axoneme Nuclear Speck Dynein Complex Motile Cilium Ciliary Transition Zone Ciliary Basal Body Cell Projection Apical Part Of Cell Ciliary Tip
	Molecular Function	Guanyl-nucleotide Exchange Factor Activity GTPase Activator Activity Calcium Ion Binding Protein Binding Zinc Ion Binding Kinase Binding Diacylglycerol Binding GTPase Regulator Activity Small GTPase Binding Metal Ion Binding	Protein Binding Dynein Heavy Chain Binding
	Biological Process	MAPK Cascade Small GTPase-mediated Signal Transduction Ras Protein Signal Transduction	Determination Of Left/right Symmetry Cell Projection Organization Intraciliary Retrograde Transport Intraciliary Transport Involved In Cilium Assembly Cilium Assembly Regulation Of Cilium Assembly
Pathways		Activation of RAS in B cells Activation of RAS in B cells RAF/MAP kinase cascade	Intraflagellar transport
Drugs
Diseases
GWAS		Albumin-globulin ratio ( 29403010) Bronchopulmonary dysplasia in preterm infants ( 30113228) Hypertension (young onset) ( 19421330) IgG response to Plasmodium falciparum antigens (GLURP, MSP2 FC27, MSP2 3D7) ( 26741287) Metabolite levels ( 23823483) Multiple system atrophy (pathologically confirmed) ( 27629089) Non-albumin protein levels ( 29403010) Non-response to antidepressants and depression ( 27622933) Sjögren's syndrome ( 24097067) Systemic lupus erythematosus ( 19838193 23273568 26663301 27399966 28714469 33272962)	Coronary artery disease ( 29212778) Diastolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858) Diastolic blood pressure x smoking status (ever vs never) interaction (2df test) ( 29455858) Hematocrit ( 32888494) Hemoglobin ( 32888494) Red blood cell count ( 32888494) Systolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858) Systolic blood pressure x smoking status (ever vs never) interaction (2df test) ( 29455858)
Interacting Genes		11 interacting genes: APP DYNLL2 GET1 HSD17B11 PIK3CA PRKACA PRKCB PRKCD PRKCE PRKCQ SULT1C2	3 interacting genes: CLIP4 DCDC2 DYNC2H1
Entrez ID		25780	51626
HPRD ID		15213	13116
Ensembl ID		ENSG00000152689	ENSG00000138036
Uniprot IDs		Q8IV61	Q8TCX1
PDB IDs			6RLB 6SC2 8RGH
Enriched GO Terms of Interacting Partners?		Diacylglycerol-dependent Serine/threonine Kinase Activity Protein Serine Kinase Activity Protein Serine/threonine Kinase Activity Positive Regulation Of Protein Localization Regulation Of Superoxide Anion Generation Positive Regulation Of Superoxide Anion Generation Positive Regulation Of Protein Transport Immune Response-regulating Cell Surface Receptor Signaling Pathway Regulation Of Superoxide Metabolic Process Positive Regulation Of Establishment Of Protein Localization Kinase Activity Cell Activation Protein Kinase C Signaling Diacylglycerol-dependent, Calcium-independent Serine/threonine Kinase Activity Peptidyl-serine Phosphorylation Negative Regulation Of Insulin Receptor Signaling Pathway Negative Regulation Of Cellular Response To Insulin Stimulus Immune Response-regulating Signaling Pathway Regulation Of Protein Transport Fc Receptor Signaling Pathway Cellular Response To Oxygen-containing Compound Positive Regulation Of Reactive Oxygen Species Metabolic Process Signaling Receptor Activator Activity Protein Kinase Activity Regulation Of Protein Localization Regulation Of Insulin Receptor Signaling Pathway Regulation Of Establishment Of Protein Localization Cellular Response To Carbohydrate Stimulus Regulation Of Cellular Response To Insulin Stimulus Immune Response-activating Cell Surface Receptor Signaling Pathway Regulation Of Immune Response Cytosol Leukocyte Activation Positive Regulation Of Insulin Secretion Positive Regulation Of Immune System Process Insulin Receptor Substrate Binding Transferase Activity Positive Regulation Of Immune Response Positive Regulation Of Peptide Hormone Secretion Positive Regulation Of Peptide Secretion Intracellular Signal Transduction Cellular Response To Hormone Stimulus Perinuclear Region Of Cytoplasm Protein Phosphorylation Regulation Of Biological Quality Immune Response-activating Signaling Pathway Myeloid Leukocyte Activation Regulation Of Generation Of Precursor Metabolites And Energy Regulation Of Supramolecular Fiber Organization Regulation Of Reactive Oxygen Species Metabolic Process	Positive Regulation Of Smoothened Signaling Pathway Kinase Binding Regulation Of Smoothened Signaling Pathway Axoneme
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