DYNC2LI1 and DYNC2H1

Number of citations of the paper that reports this interaction (PMID 12432068)
27

Data Source:
BioGRID (affinity chromatography technology)
HPRD (in vivo, in vitro)

		DYNC2LI1	DYNC2H1
Gene Name		dynein, cytoplasmic 2, light intermediate chain 1	dynein, cytoplasmic 2, heavy chain 1
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Cytosol Axonemal Dynein Complex Cytoplasmic Microtubule Axoneme Intraciliary Transport Particle Motile Primary Cilium Ciliary Basal Body Apical Part Of Cell Primary Cilium Ciliary Tip	Golgi Apparatus Cytosol Microtubule Plasma Membrane Axoneme Dynein Complex Motile Primary Cilium Apical Part Of Cell Extracellular Vesicular Exosome Primary Cilium Ciliary Tip
	Molecular Function	Motor Activity Protein Binding	Motor Activity Microtubule Motor Activity ATP Binding ATPase Activity
	Biological Process	Organelle Organization Determination Of Left/right Symmetry Metabolic Process Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Cilium Assembly	Organelle Organization Golgi Organization Determination Of Left/right Symmetry Asymmetric Protein Localization Dorsal/ventral Pattern Formation Protein Processing Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Spinal Cord Motor Neuron Differentiation Embryonic Limb Morphogenesis Forebrain Development Intraciliary Retrograde Transport Cilium Assembly Positive Regulation Of Smoothened Signaling Pathway
Pathways		Organelle biogenesis and maintenance MHC class II antigen presentation Assembly of the primary cilium Intraflagellar transport Adaptive Immune System	Organelle biogenesis and maintenance Hedgehog 'off' state MHC class II antigen presentation Signaling by Hedgehog Assembly of the primary cilium Intraflagellar transport Adaptive Immune System
Drugs
Diseases
GWAS			Small-cell lung cancer ( 21118971)
Protein-Protein Interactions		1 interactors: DYNC2H1	2 interactors: DYNC2LI1 PAXIP1
Entrez ID		51626	79659
HPRD ID		13116	10344
Ensembl ID		ENSG00000138036	ENSG00000187240
Uniprot IDs		Q8TCX1	Q8NCM8
PDB IDs
Enriched GO Terms of Interacting Partners?		Intraciliary Retrograde Transport Asymmetric Protein Localization Intraciliary Transport Spinal Cord Motor Neuron Differentiation Positive Regulation Of Smoothened Signaling Pathway Ventral Spinal Cord Development Cell Differentiation In Spinal Cord Golgi Organization Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Antigen Processing And Presentation Of Peptide Antigen Via MHC Class II Regulation Of Smoothened Signaling Pathway Antigen Processing And Presentation Of Peptide Or Polysaccharide Antigen Via MHC Class II Spinal Cord Development Determination Of Left/right Symmetry Determination Of Bilateral Symmetry Dorsal/ventral Pattern Formation Microtubule-based Transport Cytoskeleton-dependent Intracellular Transport Embryonic Limb Morphogenesis Cilium Assembly Limb Morphogenesis Cilium Organization Limb Development Cilium Morphogenesis Central Nervous System Neuron Differentiation Antigen Processing And Presentation Of Peptide Antigen Protein Processing Antigen Processing And Presentation Cell Projection Assembly Microtubule-based Movement Endomembrane System Organization Forebrain Development Organelle Assembly Pattern Specification Process	Positive Regulation Of Histone H3-K36 Methylation Chorion Development Positive Regulation Of Transcription Initiation From RNA Polymerase II Promoter Positive Regulation Of Histone H3-K4 Methylation Positive Regulation Of DNA-templated Transcription, Initiation Positive Regulation Of Histone Acetylation Regulation Of DNA-templated Transcription, Initiation Regulation Of Histone H3-K4 Methylation Positive Regulation Of Peptidyl-lysine Acetylation Positive Regulation Of Isotype Switching Positive Regulation Of Protein Acetylation Histone H3-K4 Methylation Regulation Of Isotype Switching Positive Regulation Of Immunoglobulin Mediated Immune Response Adipose Tissue Development Positive Regulation Of Histone Methylation Positive Regulation Of Immunoglobulin Production Regulation Of Histone Acetylation Regulation Of Histone Methylation Regulation Of DNA Recombination Positive Regulation Of Histone Modification Positive Regulation Of B Cell Activation DNA Damage Response, Signal Transduction By P53 Class Mediator Endothelial Cell Migration Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Antigen Processing And Presentation Of Peptide Antigen Via MHC Class II Histone Lysine Methylation Signal Transduction In Response To DNA Damage Peptidyl-lysine Methylation Vasculogenesis Epithelial Cell Migration Epithelium Migration Antigen Processing And Presentation Of Peptide Or Polysaccharide Antigen Via MHC Class II Determination Of Left/right Symmetry Signal Transduction By P53 Class Mediator Determination Of Bilateral Symmetry Histone Methylation Regulation Of Histone Modification Anatomical Structure Morphogenesis Positive Regulation Of Protein Ubiquitination Response To Ionizing Radiation Positive Regulation Of DNA Metabolic Process Positive Regulation Of Adaptive Immune Response Positive Regulation Of Protein Complex Assembly Protein Methylation Cilium Assembly Ameboidal-type Cell Migration Regulation Of Adaptive Immune Response Cilium Organization Regulation Of Protein Ubiquitination
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