GABRG2 and PPP3CA

Number of citations of the paper that reports this interaction (PubMedID 12574411)
56

Data Source:
HPRD (in vitro)

		GABRG2	PPP3CA
Description		gamma-aminobutyric acid type A receptor subunit gamma2	protein phosphatase 3 catalytic subunit alpha
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GO Annotations	Cellular Component	Plasma Membrane Membrane Axon Dendrite Cytoplasmic Vesicle Membrane Cytoplasmic Vesicle Dendrite Membrane Chloride Channel Complex Cell Projection Dendritic Spine Synapse Postsynaptic Membrane Postsynapse GABA-ergic Synapse Postsynaptic Specialization Membrane GABA-A Receptor Complex	Nucleus Nucleoplasm Cytoplasm Mitochondrion Cytosol Plasma Membrane Calcineurin Complex Protein Serine/threonine Phosphatase Complex Cytoplasmic Side Of Plasma Membrane Membrane Extrinsic Component Of Plasma Membrane Z Disc Sarcolemma Cell Projection Dendritic Spine Synapse Schaffer Collateral - CA1 Synapse Glutamatergic Synapse
	Molecular Function	Transmembrane Signaling Receptor Activity GABA-A Receptor Activity Monoatomic Ion Channel Activity Extracellular Ligand-gated Monoatomic Ion Channel Activity Chloride Channel Activity Protein Binding Benzodiazepine Receptor Activity GABA-gated Chloride Ion Channel Activity Transmitter-gated Monoatomic Ion Channel Activity Involved In Regulation Of Postsynaptic Membrane Potential	Phosphoprotein Phosphatase Activity Protein Serine/threonine Phosphatase Activity Calcium Ion Binding Protein Binding Calmodulin Binding Hydrolase Activity Enzyme Binding Calmodulin-dependent Protein Phosphatase Activity Metal Ion Binding Protein Dimerization Activity ATPase Binding
	Biological Process	Monoatomic Ion Transport Chloride Transport Gamma-aminobutyric Acid Signaling Pathway Chemical Synaptic Transmission Post-embryonic Development Adult Behavior Monoatomic Ion Transmembrane Transport Synaptic Transmission, GABAergic Regulation Of Postsynaptic Membrane Potential Cellular Response To Histamine Chloride Transmembrane Transport Inhibitory Synapse Assembly	G1/S Transition Of Mitotic Cell Cycle Protein Dephosphorylation Protein Import Into Nucleus Calcium Ion Transport Epidermis Development Positive Regulation Of Cardiac Muscle Hypertrophy Positive Regulation Of Gene Expression Negative Regulation Of Gene Expression Transition Between Fast And Slow Fiber Cardiac Muscle Hypertrophy In Response To Stress Dephosphorylation Calcium-mediated Signaling Negative Regulation Of Signaling Keratinocyte Differentiation Positive Regulation Of Cell Migration Calcineurin-NFAT Signaling Cascade Multicellular Organismal Response To Stress Wound Healing Positive Regulation Of Activated T Cell Proliferation T Cell Activation Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Skeletal Muscle Tissue Regeneration Positive Regulation Of Osteoblast Differentiation Positive Regulation Of Osteoclast Differentiation Positive Regulation Of Cell Adhesion Positive Regulation Of Endocytosis Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Saliva Secretion Skeletal Muscle Fiber Development Dendrite Morphogenesis Negative Regulation Of Dendrite Morphogenesis Modulation Of Chemical Synaptic Transmission Response To Calcium Ion Excitatory Postsynaptic Potential Regulation Of Cell Proliferation Involved In Kidney Morphogenesis Peptidyl-serine Dephosphorylation Renal Sodium Ion Absorption Positive Regulation Of Calcineurin-NFAT Signaling Cascade Positive Regulation Of Glomerulus Development Renal Filtration Calcineurin-mediated Signaling Postsynaptic Modulation Of Chemical Synaptic Transmission Negative Regulation Of Angiotensin-activated Signaling Pathway Positive Regulation Of Angiotensin-activated Signaling Pathway Positive Regulation Of Calcium Ion-dependent Exocytosis Of Neurotransmitter Positive Regulation Of Cardiac Muscle Hypertrophy In Response To Stress Positive Regulation Of Connective Tissue Replacement Positive Regulation Of Calcium Ion Import Across Plasma Membrane Negative Regulation Of Calcium Ion Import Across Plasma Membrane
Pathways		Signaling by ERBB4 GABA receptor activation GABA receptor activation	DARPP-32 events Calcineurin activates NFAT Calcineurin activates NFAT FCERI mediated Ca+2 mobilization Ca2+ pathway CLEC7A (Dectin-1) induces NFAT activation
Drugs		Lorazepam Lorazepam Ethchlorvynol Enflurane Temazepam Temazepam Butabarbital Butalbital Phenytoin Etomidate Talbutal Pentobarbital Olanzapine Clobazam Clobazam Meprobamate Carisoprodol Eszopiclone Alprazolam Alprazolam Zolpidem Metharbital Chlordiazepoxide Chlordiazepoxide Amoxapine Adinazolam Adinazolam Lamotrigine Lamotrigine Medroxyprogesterone acetate Clorazepic acid Clorazepic acid Midazolam Midazolam Flurazepam Flurazepam Isoflurane Primidone Halazepam Halazepam Propofol Diazepam Diazepam Oxazepam Oxazepam Triazolam Triazolam Zonisamide Methoxyflurane Memantine Clonazepam Clonazepam Methyprylon Halothane Desflurane Flumazenil Flumazenil Estazolam Estazolam Sevoflurane Ginkgo biloba Glutethimide Camazepam Camazepam Delorazepam Delorazepam Flunitrazepam Flunitrazepam Ethyl loflazepate Ethyl loflazepate Cloxazolam Cloxazolam Bromazepam Bromazepam Clotiazepam Clotiazepam Fludiazepam Ketazolam Ketazolam Prazepam Prazepam Quazepam Quazepam Cinolazepam Cinolazepam Nitrazepam Nitrazepam Prasterone Taurine Ganaxolone Adipiplon Brotizolam Brotizolam Stiripentol Etizolam Etizolam Thiocolchicoside Brexanolone Apalutamide Remimazolam Remimazolam Muscimol 1,2-Benzodiazepine 1,2-Benzodiazepine Pinazepam Pinazepam Medazepam Medazepam Loprazolam Loprazolam Doxefazepam Doxefazepam Lormetazepam Lormetazepam 5,7,2′-trihydroxy-6,8-dimethoxyflavone Nordazepam Nordazepam Oxazepam acetate Oxazepam acetate Cinazepam Cinazepam Bentazepam Bentazepam Mexazolam Mexazolam	Myristic acid
Diseases		Febrile seizures, including: Febrile convulsions; Generalized epilepsy with febrile seizure plus (GEFS+); Dravet syndrome/ Severe myoclonic epilepsy in infancy (SMEI) Idiopathic generalied epilepsies (IGEs), including: Childhood absence epilepsy (CAE); Juvenile absence epilepsy (JAE); Juvenile myoclonic epilepsy (JME); Epilepsy with generalized tonic-clonic seizures alone
GWAS		Angiotensin-converting enzyme inhibitor intolerance ( 28030426) Cognitive decline rate in late mild cognitive impairment ( 26252872) Femur bone mineral density x serum urate levels interaction ( 34046847) Glucagon levels in response to oral glucose tolerance test (decremental area under the curve for 0-30 minutes) ( 33407418) Nicotine dependence symptom count ( 25555482) Parkinson's disease motor subtype (tremor dominant vs postural instability/gait difficulty) ( 33987465) Post bronchodilator FEV1/FVC ratio in COPD ( 26634245) Severe influenza A (H1N1) infection ( 26379185)	Adult body size ( 32376654) Anorexia nervosa ( 24514567) Bitter non-alcoholic beverage consumption ( 31046077) Blood pressure ( 22763476) Chronotype ( 30696823) Corneal structure ( 21979947) Trunk fat mass ( 28552196) Vitiligo ( 27723757)
Interacting Genes		8 interacting genes: CFTR DRD5 GABARAP GABRA2 PPP3CA PRKCA PRKCB ZDHHC3	44 interacting genes: AATK ABI2 AKAP5 AMPH ATP2B4 BAD BCL2 BTG3 C16orf74 CABIN1 CASP3 CEBPA CRTC2 DCPH1 FAM167A FGFR4 FKBP1A FKBP8 GABRA1 GABRB2 GABRG2 GRB2 ITPKB KCNIP3 KLHL3 MARCHF7 MYOZ2 MYOZ3 OGT PLAC8 PPP3R1 PRKCZ PTK7 RCAN1 RCAN2 RYK SHANK2 SNCA SOD1 STUB1 SYNJ1 UBC UBE4B UNC119
Entrez ID		2566	5530
HPRD ID		00663	00234
Ensembl ID		ENSG00000113327	ENSG00000138814
Uniprot IDs		A0A1W2PQR9 A0A1W2PR49 A0A1W2PRN4 A0A1X7SBZ8 A8MWU7 P18507	A0A0S2Z4B5 A0A0S2Z4C6 Q08209
PDB IDs		6D6T 6D6U 6HUG 6HUJ 6HUK 6HUO 6HUP 6I53 6X3S 6X3T 6X3U 6X3V 6X3W 6X3X 6X3Z 6X40 7QNB 7QNE 7T0W 7T0Z 8DD2 8DD3 8SGO 8SI9 8SID 8VQY 8VRN 9CRS 9CRV 9CSB 9CT0 9CTJ 9CTP 9CTV 9CX7 9CXA 9CXB 9CXC 9CXD 9DRX 9EQG	1AUI 1M63 1MF8 2JOG 2JZI 2P6B 2R28 2W73 3LL8 4F0Z 4Q5U 5C1V 5SVE 6NUC 6NUF 6NUU 6UUQ 9B9G
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Angiotensin-activated Signaling Pathway Calcium,diacylglycerol-dependent Serine/threonine Kinase Activity Histone H3T6 Kinase Activity Regulation Of Exocytosis Positive Regulation Of Protein Localization Regulation Of Protein Localization Protein Kinase C Signaling Regulation Of Angiotensin-activated Signaling Pathway Positive Regulation Of Exocytosis Positive Regulation Of Insulin Secretion Positive Regulation Of Secretion By Cell Positive Regulation Of Secretion Mitotic Nuclear Membrane Disassembly Positive Regulation Of Peptide Hormone Secretion Positive Regulation Of Peptide Secretion Nuclear Membrane Disassembly Membrane Disassembly Diacylglycerol-dependent Serine/threonine Kinase Activity Monoatomic Ion Transport Regulation Of Biological Quality Positive Regulation Of Protein Secretion Positive Regulation Of Hormone Secretion Renal Sodium Ion Absorption Regulation Of G Protein-coupled Receptor Signaling Pathway Renal Sodium Ion Transport Regulation Of Insulin Secretion Positive Regulation Of Cell Communication Positive Regulation Of Signaling Modulation Of Chemical Synaptic Transmission Regulation Of Receptor Localization To Synapse Regulation Of Vesicle-mediated Transport Regulation Of Peptide Hormone Secretion Regulation Of Secretion By Cell Positive Regulation Of Intracellular Signal Transduction Regulation Of Intracellular Signal Transduction Positive Regulation Of Cardiac Muscle Hypertrophy Regulation Of Secretion Renal Absorption Positive Regulation Of G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Protein Transport Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Regulation Of Hormone Secretion Regulation Of Protein Secretion Regulation Of Synaptic Vesicle Exocytosis Nuclear Membrane Organization Chloride Channel Complex Regulation Of Cell Communication Regulation Of Signaling Intracellularly ATP-gated Chloride Channel Activity Positive Regulation Of Voltage-gated Chloride Channel Activity	Protein Phosphatase 2B Binding Regulation Of Calcineurin-mediated Signaling Regulation Of Calcineurin-NFAT Signaling Cascade Intracellular Signal Transduction Calcium-dependent Protein Serine/threonine Phosphatase Regulator Activity Calcineurin-NFAT Signaling Cascade Regulation Of Signal Transduction Calcineurin-mediated Signaling Regulation Of Intracellular Signal Transduction Intracellular Signaling Cassette Regulation Of Metal Ion Transport Cell Junction Organization Dendritic Spine Regulation Of Cell Communication Regulation Of Signaling Synapse Organization Regulation Of Calcium-mediated Signaling Regulation Of Monoatomic Cation Transmembrane Transport Regulation Of Cell Activation Cell Junction Assembly Calcium-mediated Signaling BAD-BCL-2 Complex Synapse Assembly Negative Regulation Of Calcineurin-NFAT Signaling Cascade GABA-gated Chloride Ion Channel Activity Regulation Of Monoatomic Ion Transmembrane Transport Signal Transduction Chemical Homeostasis Regulation Of Monoatomic Ion Transport Tissue Morphogenesis GABA-A Receptor Activity GABA-A Receptor Complex Chemical Synaptic Transmission Regulation Of Membrane Potential Homeostatic Process Negative Regulation Of Calcium-mediated Signaling Response To Metal Ion Trans-synaptic Signaling Z Disc Regulation Of Calcium Ion Transport Positive Regulation Of Cell Communication Positive Regulation Of Signaling Inhibitory Synapse Assembly Synaptic Signaling Regulation Of Calcium Ion Transmembrane Transport Response To Oxidative Stress Gamma-aminobutyric Acid Signaling Pathway Regulation Of Lymphocyte Activation Postsynaptic Specialization Membrane Negative Regulation Of Apoptotic Process
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