ANKK1 and CHN2

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		ANKK1	CHN2
Description		ankyrin repeat and kinase domain containing 1	chimerin 2
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Cell Projection	Cytosol Membrane Synapse
	Molecular Function	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Protein Serine Kinase Activity	GTPase Activator Activity Protein Binding Zinc Ion Binding Metal Ion Binding
	Biological Process	Regulation Of Cell Cycle Process Cellular Response To Retinoic Acid	Acrosome Assembly Signal Transduction Regulation Of Small GTPase Mediated Signal Transduction
Pathways			RAC1 GTPase cycle
Drugs		Fostamatinib
Diseases
GWAS		Alcohol consumption (drinks per week) ( 30643258) Alcoholic chronic pancreatitis ( 28754779) Body mass index ( 26426971) Experiencing mood swings ( 29500382)	Circulating leptin levels in high cardiovascular risk ( 31766143) CSF tryptophan concentration in tuberculous meningitis ( 29395996) Erosive tooth wear (severe vs non-severe) ( 29898447) Erosive tooth wear (severe vs none or mild) ( 29898447) Facial emotion recognition ( 28608620) Facial emotion recognition (angry faces) ( 28608620) Facial emotion recognition (sad faces) ( 28608620) Gut microbiota alpha diversity (PD_whole_tree index) ( 33208821) Itch intensity from mosquito bite adjusted by bite size ( 28199695) Loneliness (linear analysis) ( 27629369) Methadone dose in opioid dependence ( 28115739) Obesity-related traits ( 23251661) Psychosis (atypical) ( 24132900) Triglyceride levels ( 32203549) Waist circumference adjusted for body mass index ( 28552196)
Interacting Genes		4 interacting genes: C12orf57 CATSPERT CHN1 CHN2	14 interacting genes: ANKK1 BAG6 ERBB3 NCK1 NCK2 RAC1 RACGAP1 RANBP3 RB1 SENP8 SHF SMARCD1 TGFBR1 TP53RK
Entrez ID		255239	1124
HPRD ID		10580	04173
Ensembl ID		ENSG00000170209	ENSG00000106069
Uniprot IDs		Q8NFD2	A0A2X0TVW3 A0A994J7L4 B3VCF4 B3VCF5 B3VCF6 B3VCF9 B7Z1V0 B7Z1W9 B7Z215 P52757
PDB IDs			1XA6
Enriched GO Terms of Interacting Partners?		Regulation Of Small GTPase Mediated Signal Transduction GTPase Activator Activity Corpus Callosum Morphogenesis Psychomotor Behavior Third Ventricle Development CatSper Complex Motor Neuron Axon Guidance Ephrin Receptor Binding Developmental Process Acrosome Assembly Central Nervous System Projection Neuron Axonogenesis Central Nervous System Neuron Axonogenesis Regulation Of Skeletal Muscle Contraction Motor Behavior Camera-type Eye Morphogenesis Sperm Principal Piece Sperm Capacitation	Enzyme-linked Receptor Protein Signaling Pathway Regulation Of Translation Initiation In Response To Endoplasmic Reticulum Stress Positive Regulation Of Supramolecular Fiber Organization Lamellipodium Assembly Positive Regulation Of Response To Endoplasmic Reticulum Stress Positive Regulation Of Actin Filament Polymerization Positive Regulation Of Translation In Response To Endoplasmic Reticulum Stress Lamellipodium Organization Positive Regulation Of Translation In Response To Stress Positive Regulation Of Cytoskeleton Organization Signal Complex Assembly Regulation Of Multicellular Organismal Process Regulation Of Translation In Response To Endoplasmic Reticulum Stress Regulation Of Translational Initiation In Response To Stress Positive Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway Negative Regulation Of PERK-mediated Unfolded Protein Response Positive Regulation Of Protein Polymerization Positive Regulation Of Organelle Organization Regulation Of Response To Endoplasmic Reticulum Stress Regulation Of Actin Filament Organization Regulation Of PERK-mediated Unfolded Protein Response Cell Surface Receptor Signaling Pathway Ubiquitin Protein Ligase Binding Positive Regulation Of Immune System Process Regulation Of Actin Filament Polymerization Cytoskeletal Anchor Activity Regulation Of Translation In Response To Stress Negative Regulation Of Endoplasmic Reticulum Unfolded Protein Response Cell Morphogenesis Involved In Neuron Differentiation Cell Activation Regulation Of Actin Cytoskeleton Organization Plasma Membrane Bounded Cell Projection Assembly Positive Regulation Of Multicellular Organismal Process Positive Regulation Of Apoptotic Signaling Pathway Regulation Of Actin Polymerization Or Depolymerization Cell Projection Assembly Regulation Of Actin Filament-based Process Regulation Of Actin Filament Length Positive Regulation Of Extracellular Matrix Organization Regulation Of Supramolecular Fiber Organization Signaling Receptor Binding Regulation Of Apoptotic Signaling Pathway Regulation Of Organelle Organization SWI/SNF Complex Positive Regulation Of Gene Expression Signaling Receptor Complex Adaptor Activity Positive Regulation Of Macromolecule Metabolic Process Regulation Of Developmental Process Regulation Of Protein-containing Complex Assembly Regulation Of Cell Adhesion
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