FUCA2 and GPRC5B

Number of citations of the paper that reports this interaction (PubMedID 28298427)
90

Data Source:
BioGRID (two hybrid)

		FUCA2	GPRC5B
Description		alpha-L-fucosidase 2	G protein-coupled receptor class C group 5 member B
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Lysosome Endoplasmic Reticulum Lumen Azurophil Granule Lumen Extracellular Exosome	Extracellular Space Nucleoplasm Nucleolus Cytosol Plasma Membrane Cell Surface Membrane Cytoplasmic Vesicle Membrane Cytoplasmic Vesicle Intracellular Membrane-bounded Organelle Receptor Complex Membrane Raft Extracellular Exosome
	Molecular Function	Alpha-L-fucosidase Activity Protein Binding Hydrolase Activity Hydrolase Activity, Acting On Glycosyl Bonds	G Protein-coupled Receptor Binding G Protein-coupled Receptor Activity Protein Kinase Binding Protein Kinase Activator Activity Protein Tyrosine Kinase Binding
	Biological Process	Carbohydrate Metabolic Process Fucose Metabolic Process Response To Bacterium Glycoside Catabolic Process Regulation Of Entry Of Bacterium Into Host Cell	Cell Volume Homeostasis Signal Transduction G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Canonical NF-kappaB Signal Transduction Positive Regulation Of Neuron Differentiation Positive Regulation Of Inflammatory Response Positive Regulation Of Macrophage Cytokine Production Positive Regulation Of Protein Tyrosine Kinase Activity Positive Regulation Of Canonical Wnt Signaling Pathway
Pathways		Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Neutrophil degranulation Post-translational protein phosphorylation
Drugs
Diseases
GWAS		Multiple sclerosis ( 31604244)	Anthropometric traits ( 30166351) Anthropometric traits (multi-trait analysis) ( 30166351) Birth weight ( 31043758) Body mass index ( 20935630 25673413 26961502 28448500) Body mass index (joint analysis main effects and physical activity interaction) ( 28448500) Body mass index in physically active individuals ( 28448500) Body size at age 10 ( 32376654) Childhood body mass index ( 33045005) Hip circumference ( 25673412) L-selectin levels ( 25576479) Menarche (age at onset) ( 25231870) Obesity ( 23563607) Obesity-related traits ( 23251661) Waist circumference ( 25673412)
Interacting Genes		19 interacting genes: GPR37 GPRC5B GUCD1 HOXA1 KRTAP10-1 KRTAP4-12 KRTAP5-2 KRTAP5-3 LCE1A LCE1B LCE1E LCE4A MEOX2 NUFIP2 OGT PIN1 TNPO2 VWC2 WNT11	6 interacting genes: ADRB2 C11orf71 FUCA2 HTR2C TMEM120A TSG101
Entrez ID		2519	51704
HPRD ID		00649	16177
Ensembl ID		ENSG00000001036	ENSG00000167191
Uniprot IDs		Q9BTY2	B7Z831 Q9NZH0
PDB IDs
Enriched GO Terms of Interacting Partners?		Keratinization Epidermis Development Intermediate Filament Tissue Development Somite Development	Norepinephrine-epinephrine-mediated Vasodilation Involved In Regulation Of Systemic Arterial Blood Pressure Fat Cell Differentiation Beta-adrenergic Receptor Activity Regulation Of Systemic Arterial Blood Pressure By Norepinephrine-epinephrine Regulation Of Nervous System Process Lysosomal Transport Endosome To Lysosome Transport Positive Regulation Of Mini Excitatory Postsynaptic Potential Beta2-adrenergic Receptor Activity Alpha-L-fucosidase Activity HSP90-CDC37 Chaperone Complex Gq/11-coupled Serotonin Receptor Activity Positive Regulation Of Phosphatidylinositol Biosynthetic Process 1-(4-iodo-2,5-dimethoxyphenyl)propan-2-amine Binding Positive Regulation Of Ubiquitin-dependent Endocytosis Positive Regulation Of Viral Budding Via Host ESCRT Complex Response To Psychosocial Stress Norepinephrine Binding Vacuolar Transport Positive Regulation Of Lipophagy Response To Temperature Stimulus AMPA Selective Glutamate Receptor Signaling Pathway Biological Process Involved In Interaction With Host G Protein-coupled Serotonin Receptor Complex Regulation Of Corticotropin-releasing Hormone Secretion Exosomal Secretion Coenzyme A Binding Protein Homodimerization Activity Receptor Ligand Inhibitor Activity Telomerase Holoenzyme Complex Assembly Regulation Of Extracellular Exosome Assembly Positive Regulation Of Autophagosome Maturation Heat Generation Regulation Of Entry Of Bacterium Into Host Cell Glycoside Catabolic Process ATP-dependent Protein Binding Nitric-oxide Synthase Regulator Activity Dendritic Growth Cone TPR Domain Binding Aryl Hydrocarbon Receptor Complex Phospholipase C-activating Serotonin Receptor Signaling Pathway Adrenergic Receptor Activity Negative Regulation Of Epidermal Growth Factor-activated Receptor Activity Diet Induced Thermogenesis Serotonin Binding Serotonin Receptor Signaling Pathway Virion Binding Adenylate Cyclase Binding Negative Regulation Of Smooth Muscle Contraction Adhesion Of Symbiont To Host Cell
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