FUCA2 and LCE1E

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		FUCA2	LCE1E
Description		alpha-L-fucosidase 2	late cornified envelope 1E
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Lysosome Endoplasmic Reticulum Lumen Azurophil Granule Lumen Extracellular Exosome
	Molecular Function	Alpha-L-fucosidase Activity Protein Binding Hydrolase Activity Hydrolase Activity, Acting On Glycosyl Bonds	Protein Binding Identical Protein Binding
	Biological Process	Carbohydrate Metabolic Process Fucose Metabolic Process Response To Bacterium Glycoside Catabolic Process Regulation Of Entry Of Bacterium Into Host Cell	Epidermis Development Keratinization
Pathways		Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Neutrophil degranulation Post-translational protein phosphorylation	Formation of the cornified envelope
Drugs
Diseases
GWAS		Multiple sclerosis ( 31604244)	Asthma ( 31619474) Inflammatory skin disease ( 25574825)
Interacting Genes		19 interacting genes: GPR37 GPRC5B GUCD1 HOXA1 KRTAP10-1 KRTAP4-12 KRTAP5-2 KRTAP5-3 LCE1A LCE1B LCE1E LCE4A MEOX2 NUFIP2 OGT PIN1 TNPO2 VWC2 WNT11	67 interacting genes: ALPP CATSPER1 CYSRT1 EFEMP2 FAM9A FUCA2 GRN KRTAP1-1 KRTAP1-3 KRTAP1-5 KRTAP10-1 KRTAP10-10 KRTAP10-11 KRTAP10-5 KRTAP10-6 KRTAP10-7 KRTAP10-8 KRTAP10-9 KRTAP12-1 KRTAP12-3 KRTAP12-4 KRTAP17-1 KRTAP2-3 KRTAP2-4 KRTAP4-11 KRTAP4-12 KRTAP4-2 KRTAP4-4 KRTAP4-5 KRTAP5-11 KRTAP5-2 KRTAP5-3 KRTAP5-4 KRTAP5-6 KRTAP5-7 KRTAP5-8 KRTAP5-9 KRTAP6-3 KRTAP9-2 KRTAP9-3 KRTAP9-8 LCE1A LCE1B LCE1C LCE1D LCE1F LCE2B LCE2C LCE2D LCE3B LCE4A LCE5A MACO1 MEOX2 NBPF19 NECTIN2 NOTCH2NLA NTAQ1 PIAS2 RGS17 RGS20 RNF4 SMCP SPRY1 TGM1 TRIM42 ZCCHC7
Entrez ID		2519	353135
HPRD ID		00649	13969
Ensembl ID		ENSG00000001036	ENSG00000186226
Uniprot IDs		Q9BTY2	Q5T753
PDB IDs
Enriched GO Terms of Interacting Partners?		Keratinization Epidermis Development Intermediate Filament Tissue Development Somite Development	Intermediate Filament Keratin Filament Keratinization Epidermis Development Hair Cycle Tissue Development Cytosol Protein Binding Identical Protein Binding
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