PELI3 and IRAK2

Number of citations of the paper that reports this interaction (PubMedID 17675297)
0

Data Source:
BioGRID (affinity chromatography technology)
HPRD (in vitro)

		PELI3	IRAK2
Description		pellino E3 ubiquitin protein ligase family member 3	interleukin 1 receptor associated kinase 2
Image		No pdb structure
GO Annotations	Cellular Component	Cytosol	Nucleus Cytoplasm Cytosol Plasma Membrane Endosome Membrane
	Molecular Function	Protein Binding Transferase Activity Ubiquitin Protein Ligase Activity	Nucleotide Binding Protein Kinase Activity Protein Binding ATP Binding Signaling Adaptor Activity Protein Homodimerization Activity Protein Heterodimerization Activity Molecular Adaptor Activity
	Biological Process	Protein Polyubiquitination Immune System Process Regulation Of Toll Signaling Pathway Negative Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway Protein Ubiquitination Innate Immune Response Protein K63-linked Ubiquitination Negative Regulation Of Extrinsic Apoptotic Signaling Pathway	Regulation Of Cytokine-mediated Signaling Pathway MyD88-dependent Toll-like Receptor Signaling Pathway Protein Phosphorylation Inflammatory Response Signal Transduction Canonical NF-kappaB Signal Transduction Toll Signaling Pathway Lipopolysaccharide-mediated Signaling Pathway Toll-like Receptor 4 Signaling Pathway Intracellular Signal Transduction Non-canonical NF-kappaB Signal Transduction Positive Regulation Of Canonical NF-kappaB Signal Transduction Negative Regulation Of Canonical NF-kappaB Signal Transduction Interleukin-1-mediated Signaling Pathway Response To Interleukin-1
Pathways		Interleukin-1 signaling IRAK1 recruits IKK complex IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation	MyD88:MAL(TIRAP) cascade initiated on plasma membrane NOD1/2 Signaling Pathway TAK1-dependent IKK and NF-kappa-B activation activated TAK1 mediates p38 MAPK activation JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 Interleukin-1 signaling IRAK2 mediated activation of TAK1 complex TRAF6-mediated induction of TAK1 complex within TLR4 complex SARS-CoV-1 activates/modulates innate immune responses SARS-CoV-2 activates/modulates innate and adaptive immune responses TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation MyD88 dependent cascade initiated on endosome IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation MyD88 cascade initiated on plasma membrane
Drugs
Diseases
GWAS		Bipolar disorder ( 21926972)	Eosinophil count ( 27863252 32888494) Eosinophil percentage of granulocytes ( 27863252) Eosinophil percentage of white cells ( 27863252 32888494) Sum eosinophil basophil counts ( 27863252)
Interacting Genes		12 interacting genes: APP IRAK1 IRAK2 IRAK4 MAP3K14 MAP3K7 RIPK2 TRAF6 TRIM55 TRIM63 UBE2N UBE2V1	20 interacting genes: ARAF HRAS IL1R1 IRAK1 IRAK3 MYD88 PELI1 PELI2 PELI3 SARM1 SMAD2 SMURF1 STT3A TARDBP TICAM2 TIRAP TLR4 TOLLIP TRAF6 ZC3H12A
Entrez ID		246330	3656
HPRD ID		17535	04491
Ensembl ID		ENSG00000174516	ENSG00000134070
Uniprot IDs		Q8N2H9	O43187
PDB IDs			3MOP
Enriched GO Terms of Interacting Partners?		MyD88-dependent Toll-like Receptor Signaling Pathway Cell Surface Toll-like Receptor Signaling Pathway Toll-like Receptor 4 Signaling Pathway Positive Regulation Of Canonical NF-kappaB Signal Transduction Cell Surface Pattern Recognition Receptor Signaling Pathway Canonical NF-kappaB Signal Transduction Innate Immune Response Activating Cell Surface Receptor Signaling Pathway Interleukin-1-mediated Signaling Pathway Regulation Of Canonical NF-kappaB Signal Transduction Defense Response Response To Interleukin-1 Interleukin-33-mediated Signaling Pathway Non-canonical NF-kappaB Signal Transduction Lipopolysaccharide-mediated Signaling Pathway Response To Other Organism Positive Regulation Of Intracellular Signal Transduction Immune Response-activating Cell Surface Receptor Signaling Pathway Toll-like Receptor Signaling Pathway Immune Response Immune Response-regulating Cell Surface Receptor Signaling Pathway Immune System Process Intracellular Signaling Cassette Response To External Biotic Stimulus Pattern Recognition Receptor Signaling Pathway Innate Immune Response-activating Signaling Pathway Immune Response-activating Signaling Pathway Response To Stress Innate Immune Response Endolysosomal Toll-like Receptor Signaling Pathway Activation Of Innate Immune Response Positive Regulation Of Signal Transduction Immune Response-regulating Signaling Pathway Activation Of Immune Response Defense Response To Symbiont Regulation Of Innate Immune Response Negative Regulation Of Canonical NF-kappaB Signal Transduction Cytoplasmic Pattern Recognition Receptor Signaling Pathway Defense Response To Other Organism Positive Regulation Of Defense Response Intracellular Signal Transduction Positive Regulation Of Cell Communication Positive Regulation Of Signaling Toll Signaling Pathway Positive Regulation Of Protein K63-linked Ubiquitination Response To Cytokine Regulation Of Intracellular Signal Transduction Positive Regulation Of Innate Immune Response Response To Peptide Regulation Of Immune Response Positive Regulation Of Immune System Process	Regulation Of Canonical NF-kappaB Signal Transduction MyD88-dependent Toll-like Receptor Signaling Pathway Positive Regulation Of Canonical NF-kappaB Signal Transduction Toll-like Receptor Signaling Pathway Interleukin-1-mediated Signaling Pathway Toll-like Receptor 4 Signaling Pathway Cell Surface Toll-like Receptor Signaling Pathway Regulation Of Cell Communication Regulation Of Signaling Positive Regulation Of Immune Response Response To Lipopolysaccharide Cell Surface Pattern Recognition Receptor Signaling Pathway Response To Molecule Of Bacterial Origin Positive Regulation Of Gene Expression Positive Regulation Of Cytokine Production Regulation Of Immune Response Immune Response-activating Signaling Pathway Regulation Of Signal Transduction Response To External Biotic Stimulus Innate Immune Response Activating Cell Surface Receptor Signaling Pathway Positive Regulation Of Macromolecule Metabolic Process Immune Response-activating Cell Surface Receptor Signaling Pathway Regulation Of Cytokine Production Positive Regulation Of Cell Communication Immune Response-regulating Signaling Pathway Positive Regulation Of Signaling Regulation Of Defense Response Regulation Of Toll-like Receptor 4 Signaling Pathway Response To Other Organism Activation Of Immune Response Response To Interleukin-1 Immune Response-regulating Cell Surface Receptor Signaling Pathway Pattern Recognition Receptor Signaling Pathway Positive Regulation Of Intracellular Signal Transduction Regulation Of Innate Immune Response Lipopolysaccharide-mediated Signaling Pathway Immune System Process Positive Regulation Of Metabolic Process Innate Immune Response-activating Signaling Pathway Positive Regulation Of Innate Immune Response Cellular Response To Molecule Of Bacterial Origin Positive Regulation Of Signal Transduction Activation Of Innate Immune Response Positive Regulation Of Multicellular Organismal Process Positive Regulation Of Immune System Process Defense Response To Other Organism Defense Response Response To Lipid Regulation Of Type I Interferon Production Innate Immune Response
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