PELI3

Description		pellino E3 ubiquitin protein ligase family member 3
Image		No pdb structure
GO Annotations	Cellular Component	Cytosol
	Molecular Function	Protein Binding Transferase Activity Ubiquitin Protein Ligase Activity
	Biological Process	Protein Polyubiquitination Immune System Process Regulation Of Toll Signaling Pathway Negative Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway Protein Ubiquitination Innate Immune Response Protein K63-linked Ubiquitination Negative Regulation Of Extrinsic Apoptotic Signaling Pathway
Pathways		Interleukin-1 signaling IRAK1 recruits IKK complex IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation
Drugs
Diseases
GWAS		Bipolar disorder ( 21926972)
Interacting Genes		12 interacting genes: APP IRAK1 IRAK2 IRAK4 MAP3K14 MAP3K7 RIPK2 TRAF6 TRIM55 TRIM63 UBE2N UBE2V1
Entrez ID		246330
HPRD ID		17535
Ensembl ID		ENSG00000174516
Uniprot IDs		Q8N2H9
PDB IDs
Enriched GO Terms of Interacting Partners?		MyD88-dependent Toll-like Receptor Signaling Pathway Cell Surface Toll-like Receptor Signaling Pathway Toll-like Receptor 4 Signaling Pathway Positive Regulation Of Canonical NF-kappaB Signal Transduction Cell Surface Pattern Recognition Receptor Signaling Pathway Canonical NF-kappaB Signal Transduction Innate Immune Response Activating Cell Surface Receptor Signaling Pathway Interleukin-1-mediated Signaling Pathway Regulation Of Canonical NF-kappaB Signal Transduction Defense Response Response To Interleukin-1 Interleukin-33-mediated Signaling Pathway Non-canonical NF-kappaB Signal Transduction Lipopolysaccharide-mediated Signaling Pathway Response To Other Organism Positive Regulation Of Intracellular Signal Transduction Immune Response-activating Cell Surface Receptor Signaling Pathway Toll-like Receptor Signaling Pathway Immune Response Immune Response-regulating Cell Surface Receptor Signaling Pathway Immune System Process Intracellular Signaling Cassette Response To External Biotic Stimulus Pattern Recognition Receptor Signaling Pathway Innate Immune Response-activating Signaling Pathway Immune Response-activating Signaling Pathway Response To Stress Innate Immune Response Endolysosomal Toll-like Receptor Signaling Pathway Activation Of Innate Immune Response Positive Regulation Of Signal Transduction Immune Response-regulating Signaling Pathway Activation Of Immune Response Defense Response To Symbiont Regulation Of Innate Immune Response Negative Regulation Of Canonical NF-kappaB Signal Transduction Cytoplasmic Pattern Recognition Receptor Signaling Pathway Defense Response To Other Organism Positive Regulation Of Defense Response Intracellular Signal Transduction Positive Regulation Of Cell Communication Positive Regulation Of Signaling Toll Signaling Pathway Positive Regulation Of Protein K63-linked Ubiquitination Response To Cytokine Regulation Of Intracellular Signal Transduction Positive Regulation Of Innate Immune Response Response To Peptide Regulation Of Immune Response Positive Regulation Of Immune System Process
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