YIPF6 and GJA5

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		YIPF6	GJA5
Description		Yip1 domain family member 6	gap junction protein alpha 5
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Golgi Trans Cisterna Golgi Membrane Endoplasmic Reticulum Golgi Apparatus Golgi Medial Cisterna Cis-Golgi Network Trans-Golgi Network Endomembrane System Membrane COPII-coated ER To Golgi Transport Vesicle	Plasma Membrane Gap Junction Connexin Complex Intercalated Disc Membrane Cell Projection Anchoring Junction
	Molecular Function	Protein Binding Identical Protein Binding	Gap Junction Channel Activity Protein Binding Gap Junction Hemi-channel Activity Connexin Binding Gap Junction Channel Activity Involved In SA Node Cell-atrial Cardiac Muscle Cell Electrical Coupling Gap Junction Channel Activity Involved In Cardiac Conduction Electrical Coupling Gap Junction Channel Activity Involved In Atrial Cardiac Muscle Cell-AV Node Cell Electrical Coupling Gap Junction Channel Activity Involved In AV Node Cell-bundle Of His Cell Electrical Coupling Gap Junction Channel Activity Involved In Bundle Of His Cell-Purkinje Myocyte Electrical Coupling Gap Junction Channel Activity Involved In Purkinje Myocyte-ventricular Cardiac Muscle Cell Electrical Coupling Disordered Domain Specific Binding
	Biological Process	Endoplasmic Reticulum To Golgi Vesicle-mediated Transport Intestinal Epithelial Cell Development	Skeletal System Development Angiogenesis Blood Vessel Development Renal System Process Involved In Regulation Of Systemic Arterial Blood Pressure Regulation Of Systemic Arterial Blood Pressure Negative Regulation Of Glomerular Filtration Outflow Tract Morphogenesis Endothelium Development Cardiac Conduction System Development Mitral Valve Development Pulmonary Valve Formation Ventricular Septum Development Atrial Septum Development Septum Primum Development Atrial Ventricular Junction Remodeling Potassium Ion Transport Cell Communication Cell-cell Signaling Heart Development Cell Communication By Chemical Coupling Cell Communication By Electrical Coupling Regulation Of Cell Communication By Electrical Coupling Positive Regulation Of Cell Communication By Chemical Coupling Gap Junction Assembly Embryonic Limb Morphogenesis Embryonic Heart Tube Development Foramen Ovale Closure Vasodilation Negative Regulation Of Blood Pressure Positive Regulation Of Vasoconstriction Artery Morphogenesis Transmembrane Transport Regulation Of Cardiac Muscle Contraction Regulation Of Ventricular Cardiac Muscle Cell Membrane Repolarization Regulation Of Atrial Cardiac Muscle Cell Membrane Depolarization Regulation Of Ventricular Cardiac Muscle Cell Membrane Depolarization Ventricular Septum Morphogenesis Atrial Septum Morphogenesis Cardiac Conduction Ventricular Cardiac Muscle Cell Action Potential SA Node Cell Action Potential SA Node Cell To Atrial Cardiac Muscle Cell Communication By Electrical Coupling Atrial Cardiac Muscle Cell To AV Node Cell Communication By Electrical Coupling AV Node Cell To Bundle Of His Cell Communication By Electrical Coupling Bundle Of His Cell To Purkinje Myocyte Communication By Electrical Coupling Purkinje Myocyte To Ventricular Cardiac Muscle Cell Communication By Electrical Coupling Cell Communication By Electrical Coupling Involved In Cardiac Conduction Cell Communication Involved In Cardiac Conduction AV Node Cell To Bundle Of His Cell Communication Regulation Of Heart Rate By Cardiac Conduction Blood Vessel Diameter Maintenance Regulation Of AV Node Cell Action Potential Regulation Of Bundle Of His Cell Action Potential Regulation Of Purkinje Myocyte Action Potential Regulation Of Atrial Cardiac Muscle Cell Action Potential Regulation Of Renin Secretion Into Blood Stream Regulation Of Membrane Depolarization During Cardiac Muscle Cell Action Potential Vasomotion
Pathways		Golgi Associated Vesicle Biogenesis	Gap junction assembly
Drugs
Diseases			Atrial fibrillation
GWAS		Male-pattern baldness ( 28196072)	Atrial fibrillation ( 29892015 30061737) Cognitive performance ( 20125193) Methotrexate-induced interstitial lung disease in rheumatoid arthritis ( 28500057) PR interval ( 32439900) Triglyceride levels ( 34074324)
Interacting Genes		93 interacting genes: APOL2 AQP2 AQP6 ARL13B ATP6V0E1 CD79A CGRRF1 CISD2 CLN8 CNR2 CPLX4 CRB3 CREB3L1 CREB3L3 CXorf66 CYSLTR2 EBP EFNA5 ELOVL4 ERGIC3 F2RL1 FAM209A FCER1G FFAR2 FKBP7 GJA5 GJA8 GJB1 GPR101 GPR152 GPR42 GPX8 HSD17B11 IL10RA IL1RL1 IL27RA JKAMP KCNJ6 KCNK5 LMNA LRRC25 LRRC3B LRRC4C LY6G6C LYVE1 MMD MS4A3 MTIF3 MUC1 NDUFAF1 ODF4 PDZK1IP1 PSCA RAET1L REEP4 RETREG3 RHCG RNF185 SCN3B SLC10A1 SLC10A6 SLC12A7 SLC17A8 SLC18A1 SLC30A4 SLC30A8 SLC35H1 SLC38A7 SLC39A1 SLC39A2 SLC61A1 SLC71A2 SLC7A14 SLC7A8 SSMEM1 STOM TCTA THAP4 TMEM106C TMEM11 TMEM130 TMEM14B TMEM237 TMEM31 TMEM52B TMEM71 TMX2 TRARG1 TRHR TVP23B ULBP2 YIPF1 YIPF2	34 interacting genes: AAR2 ABHD16A ARLN BLCAP EMP3 FCER1G GJA1 GJB2 IGFBP5 LEPROT LEPROTL1 LHFPL2 MARK1 MS4A13 NIPAL3 NKG7 PGAP2 PRAF2 PRKACA RIMS3 RPRM SLC13A4 SLC30A2 SLC35F1 SLC41A1 SLC41A2 SLC61A1 SLC66A1 TMBIM6 TMEM107 TREX1 UBQLN4 VRK2 YIPF6
Entrez ID		286451	2702
HPRD ID		06639	08699
Ensembl ID		ENSG00000181704	ENSG00000265107
Uniprot IDs		Q96EC8	P36382 X5D2H9
PDB IDs
Enriched GO Terms of Interacting Partners?		Membrane Transmembrane Transport Plasma Membrane Protein Binding Endoplasmic Reticulum Monoatomic Ion Transport Zinc Ion Transmembrane Transporter Activity Monoatomic Cation Transport Zinc Ion Transmembrane Transport Zinc Ion Transport Metal Ion Transport Inorganic Cation Transmembrane Transport Endoplasmic Reticulum Membrane Inorganic Ion Transmembrane Transport Regulation Of Renin Secretion Into Blood Stream Amino Acid Transmembrane Transport Connexin Complex Import Across Plasma Membrane Gap Junction Channel Activity Carbon Dioxide Transmembrane Transporter Activity Carbon Dioxide Transmembrane Transport Bile Acid:sodium Symporter Activity Positive Regulation Of Acute Inflammatory Response Gap Junction Transmembrane Transporter Activity SA Node Cell Action Potential Side Of Membrane Amino Acid Transport Carboxylic Acid Transport Organic Acid Transport Organic Anion Transport Regulation Of Ventricular Cardiac Muscle Cell Membrane Depolarization Monoatomic Cation Transmembrane Transport Neurotransmitter Loading Into Synaptic Vesicle Renal Water Transport Monoatomic Ion Transmembrane Transport Gap Junction Assembly Golgi Trans Cisterna Antigen Processing And Presentation Of Peptide Antigen Via MHC Class I Ammonium Channel Activity G Protein-coupled Receptor Activity Regulation Of Atrial Cardiac Muscle Cell Membrane Depolarization Golgi Medial Cisterna	Membrane Monoatomic Cation Transmembrane Transporter Activity Magnesium Ion Transport Magnesium Ion Transmembrane Transporter Activity Magnesium Ion Transmembrane Transport Transmembrane Transport Cell Communication By Electrical Coupling Gap Junction Channel Activity Involved In Cell Communication By Electrical Coupling Inorganic Cation Transmembrane Transporter Activity Gap Junction Assembly Negative Regulation Of Growth Hormone Receptor Signaling Pathway Regulation Of Growth Hormone Receptor Signaling Pathway Protein Binding Monoatomic Ion Transport Transmembrane Transporter Activity Cell Communication By Electrical Coupling Involved In Cardiac Conduction Monoatomic Ion Transmembrane Transport Connexin Complex Gap Junction Channel Activity
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