SLC29A2 and GJA4

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		SLC29A2	GJA4
Description		solute carrier family 29 member 2	gap junction protein alpha 4
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleolus Plasma Membrane Membrane Basolateral Plasma Membrane Apical Plasma Membrane	Plasma Membrane Gap Junction Connexin Complex Membrane Anchoring Junction
	Molecular Function	Neurotransmitter Transmembrane Transporter Activity Nucleoside Transmembrane Transporter Activity Nucleobase Transmembrane Transporter Activity Adenine Transmembrane Transporter Activity Guanine Transmembrane Transporter Activity Uracil Transmembrane Transporter Activity Purine Nucleoside Transmembrane Transporter Activity Cytidine Transmembrane Transporter Activity Uridine Transmembrane Transporter Activity	Gap Junction Channel Activity Protein Binding
	Biological Process	Neurotransmitter Uptake Neurotransmitter Transport Xenobiotic Transmembrane Transport Nucleobase Transport Adenine Transport Guanine Transport Nucleoside Transport Purine Nucleoside Transmembrane Transport Cytidine Transport Uridine Transmembrane Transport Adenosine Transport Inosine Transport Hypoxanthine Transport Thymine Transport Pyrimidine-containing Compound Transmembrane Transport Transport Across Blood-brain Barrier Nucleoside Transmembrane Transport Guanine Transmembrane Transport Uracil Transmembrane Transport Purine Nucleobase Transmembrane Transport	Blood Vessel Development Cell-cell Junction Assembly Cell Communication Cell-cell Signaling Transmembrane Transport
Pathways		Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane Azathioprine ADME	Gap junction assembly
Drugs		Ethanol
Diseases
GWAS		Bipolar disorder ( 21926972) Serum metabolite levels ( 33031748) Serum uric acid levels ( 32514006)	Formal thought disorder in schizophrenia ( 22648509) Triglyceride levels x thiazide or thiazide-like diuretics use interaction ( 31806883)
Interacting Genes		19 interacting genes: ALOX5AP CERS3 CERS4 CREB3 ERGIC3 GJA4 GPR152 LAPTM4B PLPP5 SERINC2 SLC10A1 SLC10A6 TMEM237 TMEM242 TMEM33 TMEM86B TMX2 UBQLN1 UBQLN2	5 interacting genes: CD81 MS4A13 OPRM1 SLC29A2 TMEM86B
Entrez ID		3177	2701
HPRD ID		03662	08509
Ensembl ID		ENSG00000174669	ENSG00000187513
Uniprot IDs		Q14542 Q96FB2	P35212
PDB IDs
Enriched GO Terms of Interacting Partners?		Membrane Regulation Of Response To Endoplasmic Reticulum Stress Endoplasmic Reticulum Membrane Endoplasmic Reticulum Bile Acid:sodium Symporter Activity Positive Regulation Of Response To Endoplasmic Reticulum Stress Sphingosine N-acyltransferase Activity Response To Endoplasmic Reticulum Stress Positive Regulation Of ERAD Pathway Bile Acid And Bile Salt Transport Regulation Of ERAD Pathway Positive Regulation Of Deacetylase Activity Polyubiquitin Modification-dependent Protein Binding Negative Regulation Of Store-operated Calcium Channel Activity D-lysine 5,6-aminomutase Activity Sodium-dependent Organic Anion Transmembrane Transporter Activity Sodium-dependent Organic Anion Transport Leukotriene Production Involved In Inflammatory Response Regulation Of Vacuole Organization Negative Regulation Of G Protein-coupled Receptor Internalization Retrograde Transporter Complex, Golgi To ER Regulation Of Lysosomal Membrane Permeability Ceramide Biosynthetic Process Ether Hydrolase Activity Alkenylglycerophosphocholine Hydrolase Activity	Positive Regulation Of T Cell Activation Via T Cell Receptor Contact With Antigen Bound To MHC Molecule On Antigen Presenting Cell Macrophage Fusion Positive Regulation Of Adaptive Immune Memory Response CD4-positive, Alpha-beta T Cell Costimulation Myoblast Fusion Involved In Skeletal Muscle Regeneration Cytidine Transmembrane Transporter Activity Uracil Transmembrane Transport Thymine Transport Inosine Transport Pyrimidine Nucleobase Transmembrane Transport Nucleobase Transmembrane Transporter Activity Cytidine Transport Uracil Transmembrane Transporter Activity Purine Nucleoside Transmembrane Transport Guanine Transmembrane Transporter Activity Guanine Transport Guanine Transmembrane Transport Adenosine Transport Hypoxanthine Transport Purine Nucleoside Transmembrane Transporter Activity Regulation Of NMDA Receptor Activity Cellular Response To Morphine Morphine Receptor Activity Negative Regulation Of Wnt Protein Secretion Beta-endorphin Receptor Activity D-lysine 5,6-aminomutase Activity Ether Hydrolase Activity Alkenylglycerophosphocholine Hydrolase Activity Humoral Immune Response Mediated By Circulating Immunoglobulin Uridine Transmembrane Transport Adenine Transmembrane Transporter Activity Pyrimidine Nucleoside Transport Nucleoside Transmembrane Transporter Activity Uridine Transmembrane Transporter Activity MHC Class II Protein Binding Osteoclast Fusion Nucleoside Transmembrane Transport Adenine Transport Nucleoside Transport Pyrimidine Nucleobase Transport Positive Regulation Of Protein Catabolic Process In The Vacuole Purine Nucleobase Transmembrane Transport G Protein-coupled Opioid Receptor Activity Positive Regulation Of B Cell Receptor Signaling Pathway Adenylate Cyclase-inhibiting G Protein-coupled Acetylcholine Receptor Signaling Pathway Basolateral Plasma Membrane Positive Regulation Of T-helper 2 Cell Cytokine Production Tetraspanin-enriched Microdomain G Protein-coupled Opioid Receptor Signaling Pathway Positive Regulation Of CD4-positive, Alpha-beta T Cell Proliferation
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