CCNE2

Description		cyclin E2
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Microtubule Organizing Center Cytosol Cyclin E1-CDK2 Complex Cyclin E2-CDK2 Complex
	Molecular Function	Protein Binding Cyclin-dependent Protein Serine/threonine Kinase Regulator Activity Protein Kinase Binding
	Biological Process	Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity G1/S Transition Of Mitotic Cell Cycle Telomere Maintenance DNA Replication Initiation Homologous Chromosome Pairing At Meiosis Regulation Of Protein Localization Cell Division Regulation Of Cell Cycle Chromosome Organization Involved In Meiotic Cell Cycle Positive Regulation Of G1/S Transition Of Mitotic Cell Cycle
Pathways		G0 and Early G1 SCF(Skp2)-mediated degradation of p27/p21 DNA Damage/Telomere Stress Induced Senescence Association of TriC/CCT with target proteins during biosynthesis TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest CDK-mediated phosphorylation and removal of Cdc6 Phosphorylation of proteins involved in G1/S transition by active Cyclin E:Cdk2 complexes Cyclin E associated events during G1/S transition Cyclin D associated events in G1 p53-Dependent G1 DNA Damage Response Defective binding of RB1 mutants to E2F1,(E2F2, E2F3)
Drugs
Diseases		Laryngeal cancer Gastric cancer
GWAS		Keratoconus ( 33649486)
Interacting Genes		12 interacting genes: APP CDK2 CDK3 CDKN1A CDKN1B CDKN1C FBXO7 FBXW7 ORC3 SUMO2 SUMO3 ZDHHC17
Entrez ID		9134
HPRD ID		04801
Ensembl ID		ENSG00000175305
Uniprot IDs		O96020
PDB IDs		8HN9
Enriched GO Terms of Interacting Partners?		Cyclin Binding Regulation Of Mitotic Cell Cycle Cell Cycle G1/S Phase Transition G1/S Transition Of Mitotic Cell Cycle Regulation Of Cell Cycle Phase Transition Mitotic Cell Cycle Phase Transition Regulation Of Mitotic Cell Cycle Phase Transition Negative Regulation Of Cyclin-dependent Protein Kinase Activity Cell Cycle Phase Transition Cyclin-dependent Protein Serine/threonine Kinase Inhibitor Activity Regulation Of Cell Cycle Regulation Of Cell Cycle G1/S Phase Transition Regulation Of Cell Cycle Process Negative Regulation Of Mitotic Cell Cycle Negative Regulation Of Cardiac Muscle Tissue Regeneration Regulation Of DNA Replication Ubiquitin Protein Ligase Binding Molecular Function Inhibitor Activity Negative Regulation Of Cell Cycle Regulation Of Protein Catabolic Process Positive Regulation Of DNA Replication Regulation Of G1/S Transition Of Mitotic Cell Cycle Cyclin-dependent Protein Kinase Holoenzyme Complex Protein Kinase Inhibitor Activity Positive Regulation Of Protein Catabolic Process Cellular Senescence Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle Regulation Of Lens Fiber Cell Differentiation Negative Regulation Of Cell Cycle G1/S Phase Transition Negative Regulation Of Protein Kinase Activity Negative Regulation Of Kinase Activity Regulation Of Protein Metabolic Process Positive Regulation Of Catabolic Process Protein Tag Activity Regulation Of G2/M Transition Of Mitotic Cell Cycle Negative Regulation Of Protein Phosphorylation Mitotic G1 DNA Damage Checkpoint Signaling Mitotic G1/S Transition Checkpoint Signaling Regulation Of Exit From Mitosis Negative Regulation Of Phosphorylation Regulation Of Cell Cycle G2/M Phase Transition Negative Regulation Of Cell Population Proliferation Regulation Of Oxidative Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Regulation Of Proteolysis Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Protein Serine/threonine Kinase Binding DNA Damage Response Positive Regulation Of Nucleobase-containing Compound Metabolic Process Molecular Function Activator Activity Negative Regulation Of Epithelial Cell Proliferation
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