CDK20 and GTF2IRD1

Number of citations: 36 (PubMedID 18508765)
Data Source: HPRD (two hybrid)

		CDK20	GTF2IRD1
Name		cyclin dependent kinase 20	GTF2I repeat domain containing 1
Structure		No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Golgi Apparatus Cilium Cell Projection	Nucleus Nucleoplasm Cytosol
	Molecular Function	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Cyclin-dependent Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Protein Serine Kinase Activity	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding
	Biological Process	Neural Tube Closure Regulation Of Smoothened Signaling Pathway Floor Plate Formation Embryonic Camera-type Eye Development Negative Regulation Of Smoothened Signaling Pathway Embryonic Skeletal System Development Cell Division Regulation Of Cell Cycle Roof Of Mouth Development Protein Localization To Cilium Regulation Of Protein Maturation Embryonic Brain Development	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of DNA-templated Transcription Transcription By RNA Polymerase II Transition Between Slow And Fast Fiber
GWAS		No GWAS studies recorded	Age at suicide ( 31476763 ) Aluminium levels ( 26025379 ) General factor of neuroticism ( 30867560 ) Neuroticism ( 29255261 ) Rheumatoid arthritis ( 32723749 ) Severe influenza A (H1N1) infection ( 26379185 ) Sjögren's syndrome ( 24097066 ) Systemic lupus erythematosus ( 26663301 28714469 ) Triglyceride levels ( 32203549 )
Novel Interactors		1 novel interactors: NTRK2	1 novel interactors: COL15A1
Interacting Genes		9 interacting genes: CCNH CDK2 CILK1 CSNK2B GTF2IRD1 GTF2IRD2 PANK4 PPP5C TRIM2	24 interacting genes: ALMS1 ATP2C1 CDK20 DCAF6 EXOSC4 GORASP2 HDAC3 HTRA4 KPNA1 KPNA2 KPNA3 KPNA4 MRFAP1L1 PIAS1 PIAS2 PIP4P2 PKP1 PKP2 SELENOS SMAD3 SPTLC1 UBC USP20 ZMYM5
Entrez ID		23552	9569
HPRD ID		13010	08379
Ensembl ID		ENSG00000156345	ENSG00000006704
Uniprot IDs		A0A0S2Z562 A0A0S2Z5B6 Q8IZL9	E9PFE2 Q9UHL9
PDB IDs		Not available	2D99 2DN5 2DZQ 2DZR
GO Terms Enriched among Interactors		Phosphate-containing Compound Metabolic Process Phosphorylation Protein Phosphorylation DNA-templated Transcription Nucleobase-containing Compound Biosynthetic Process Protein Modification Process Kinase Activity Cyclin-dependent Protein Kinase Holoenzyme Complex Male Germ Cell Nucleus ATP Binding Brain-derived Neurotrophic Factor Receptor Activity Transition Between Slow And Fast Fiber Macromolecule Metabolic Process Y Chromosome Positive Regulation Of Heterochromatin Formation Cyclin A1-CDK2 Complex Cyclin E2-CDK2 Complex Positive Regulation Of DNA-templated DNA Replication Initiation Positive Regulation Of Nuclear Receptor-mediated Glucocorticoid Signaling Pathway Phosphatase Activity Pantothenate Kinase Activity Transcription Factor TFIIK Complex Positive Regulation Of Chromatin Organization Protein Serine/threonine Kinase Activity Cyclin-dependent Protein Kinase Activity Cyclin A2-CDK2 Complex Cyclin E1-CDK2 Complex Protein Kinase CK2 Complex Symbiont-mediated Disruption Of Host Cell PML Body Trans-synaptic Signaling By BDNF, Modulating Synaptic Transmission Brain-derived Neurotrophic Factor Binding Response To Arachidonate Peptidyl-serine Dephosphorylation CAK-ERCC2 Complex X Chromosome Brain-derived Neurotrophic Factor Receptor Signaling Pathway Neurotrophin Receptor Activity Trans-synaptic Signaling By BDNF Neurotrophin Binding Protein Kinase Activity Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Protein Metabolic Process Release From Viral Latency Pantothenate Metabolic Process Regulation Of Anaphase-promoting Complex-dependent Catabolic Process Histone Kinase Activity Positive Regulation Of Activin Receptor Signaling Pathway Negative Regulation Of Viral Life Cycle Regulation Of G1/S Transition Of Mitotic Cell Cycle Protection From Non-homologous End Joining At Telomere	NLS-dependent Protein Nuclear Import Complex Nuclear Import Signal Receptor Activity Nuclear Localization Sequence Binding NLS-bearing Protein Import Into Nucleus Viral Penetration Into Host Nucleus Protein Import Into Nucleus Import Into Nucleus Intermediate Filament Binding Intracellular Transport Of Virus Intermediate Filament Bundle Assembly Desmosome Assembly Nucleoplasm Host Cell Protein Localization To Nucleus SUMO Ligase Activity Positive Regulation Of Protein Localization To Cell Periphery Desmosome Organization Nuclear Pore Ubiquitin-specific Protease Binding Positive Regulation Of Protein Localization SUMO Transferase Activity Nuclear Transport Nucleocytoplasmic Transport SMAD Protein Signal Transduction Desmosome Ubiquitin Protein Ligase Binding Intracellular Protein Transport Cellular Localization Collagen Type XV Trimer Establishment Of Protein Localization To Organelle Negative Regulation Of Lung Blood Pressure Nuclear Mineralocorticoid Receptor Binding Positive Regulation Of Protein Import Into Nucleus Regulation Of Protein Localization To Cell Periphery Maintenance Of Protein Localization At Cell Tip Positive Regulation Of Ferroptosis