SRRM2 and SNIP1

Number of citations of the paper that reports this interaction (PubMedID 33961781)
97

Data Source:
BioGRID (affinity chromatography technology)

		SRRM2	SNIP1
Description		serine/arginine repetitive matrix 2	Smad nuclear interacting protein 1
Image
GO Annotations	Cellular Component	Nucleus Nucleoplasm Spliceosomal Complex Cajal Body Nuclear Speck U2-type Precatalytic Spliceosome U2-type Catalytic Step 2 Spliceosome Catalytic Step 2 Spliceosome	Nucleus Nucleoplasm Spliceosomal Complex U2 SnRNP Cytosol U2-type Precatalytic Spliceosome
	Molecular Function	RNA Binding MRNA Binding Protein Binding C2H2 Zinc Finger Domain Binding	RNA Binding MRNA Binding Protein Binding Transcription Regulator Inhibitor Activity
	Biological Process	MRNA Splicing, Via Spliceosome MRNA Processing RNA Splicing	MRNA Splicing, Via Spliceosome MRNA Processing RNA Splicing Regulation Of Gene Expression Regulatory NcRNA-mediated Gene Silencing MiRNA Processing Negative Regulation Of Canonical NF-kappaB Signal Transduction U2-type Prespliceosome Assembly
Pathways		mRNA Splicing - Major Pathway	mRNA Splicing - Major Pathway
Drugs
Diseases
GWAS		Height ( 31562340) Venous thromboembolism ( 32232851)	Axial length ( 24144296) Eyebrow thickness ( 26926045)
Interacting Genes		16 interacting genes: APP CEBPA CLK1 CSNK2A1 PIN1 PNN PRPF6 SRPK2 SRRM1 SRSF4 SUMO2 TTC14 USP7 XRN1 YWHAB YWHAG	47 interacting genes: CDK6 CREBBP DVL2 DVL3 EIF3C EP300 ESRRG FAF1 GMEB1 GYS1 HIPK1 HIPK3 KRTAP10-6 MAX MYC PHF19 PIAS1 PIAS2 PIAS3 PIAS4 POU2F1 PRPF3 PRPF40A RELA SETDB1 SF3B1 SMAD1 SMAD2 SMAD4 SON SP100 SPANXN2 SRPK2 SRRM4 STK3 TDG TNIP1 TOPORS TSPYL2 TTC14 UBE2I ZBTB9 ZCCHC10 ZCCHC7 ZMYM2 ZMYM5 ZNF451
Entrez ID		23524	79753
HPRD ID		06913	06999
Ensembl ID		ENSG00000167978	ENSG00000163877
Uniprot IDs		A0A140VK53 Q9UQ35	B1AK66 Q8TAD8
PDB IDs		5MQF 5XJC 5YZG 5Z56 5Z57 6FF4 6FF7 6ICZ 6QDV 6ZYM 7A5P 7DVQ 7QTT 7W59 7W5A 7W5B 8C6J 8CH6 8I0R 8I0S 8I0T 8I0U 8I0V 8I0W 9FMD	5Z56 5Z57 5Z58 6FF7 7ABG 7ABH 7ABI 7DVQ 8I0P 8I0R
Enriched GO Terms of Interacting Partners?		MRNA Metabolic Process Regulation Of Macromolecule Biosynthetic Process Regulation Of Gene Expression Regulation Of Protein Catabolic Process RNA Splicing Nucleus RNA Splicing, Via Transesterification Reactions Regulation Of Macromolecule Metabolic Process RNA Metabolic Process Nuclear Speck Symbiont-mediated Disruption Of Host Cell PML Body MRNA Processing Nucleic Acid Metabolic Process RNA Binding Macromolecule Metabolic Process Regulation Of Primary Metabolic Process Regulation Of Metabolic Process Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Spliceosomal Complex Assembly Phosphoserine Residue Binding Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Ubiquitin-dependent Protein Catabolic Process Regulation Of Proteolysis Regulation Of RNA Splicing Spliceosomal Complex Negative Regulation Of Macromolecule Metabolic Process Nucleobase-containing Compound Metabolic Process MRNA Splicing, Via Spliceosome Regulation Of Proteasomal Protein Catabolic Process Regulation Of Protein Metabolic Process Protein Targeting Positive Regulation Of Protein Catabolic Process Negative Regulation Of Gene Expression Presynapse Regulation Of RNA Metabolic Process Negative Regulation Of Metabolic Process Protein Stabilization Negative Regulation Of Macromolecule Biosynthetic Process Catalytic Step 2 Spliceosome Positive Regulation Of Protein Metabolic Process Negative Regulation Of Biosynthetic Process RNA Processing Positive Regulation Of Catabolic Process PML Body Regulation Of MRNA Splicing, Via Spliceosome Negative Regulation Of Protein Metabolic Process Negative Regulation Of Protein Catabolic Process Negative Regulation Of Signal Transduction Nucleoplasm Regulation Of MRNA Processing	Regulation Of Nucleobase-containing Compound Metabolic Process PML Body Chromatin Regulation Of RNA Metabolic Process Regulation Of Transcription By RNA Polymerase II Regulation Of Macromolecule Metabolic Process Nucleoplasm Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process Nucleus Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Metabolic Process Regulation Of Primary Metabolic Process SUMO Transferase Activity Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of RNA Metabolic Process Protein Sumoylation SUMO Ligase Activity Positive Regulation Of RNA Metabolic Process Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of DNA-templated Transcription Negative Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Transcription Coregulator Activity Positive Regulation Of Transcription By RNA Polymerase II DNA Binding Positive Regulation Of Biosynthetic Process SMAD Protein Signal Transduction Positive Regulation Of MiRNA Transcription Negative Regulation Of Macromolecule Metabolic Process Nucleic Acid Metabolic Process Negative Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Metabolic Process Negative Regulation Of Biosynthetic Process Positive Regulation Of MiRNA Metabolic Process Transcription Regulator Complex DNA-binding Transcription Factor Binding Nuclear Speck DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Negative Regulation Of Metabolic Process Regulation Of MiRNA Transcription DNA-binding Transcription Factor Activity, RNA Polymerase II-specific RNA Metabolic Process Regulation Of MiRNA Metabolic Process Nucleobase-containing Compound Metabolic Process
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