SPIDR and FIGNL1

Number of citations of the paper that reports this interaction (PubMedID 23754376)
30

Data Source:
BioGRID (pull down)

		SPIDR	FIGNL1
Description		scaffold protein involved in DNA repair	fidgetin like 1
Image		No pdb structure
GO Annotations	Cellular Component	Nuclear Chromosome Nucleus Nucleoplasm	Nuclear Chromosome Nucleus Nucleoplasm Cytoplasm Perinuclear Region Of Cytoplasm Extracellular Exosome
	Molecular Function	Protein Binding	Nucleotide Binding Magnesium Ion Binding Protein Binding ATP Binding Microtubule Severing ATPase Activity Hydrolase Activity ATP Hydrolysis Activity Metal Ion Binding
	Biological Process	Double-strand Break Repair Via Homologous Recombination DNA Repair DNA Recombination DNA Damage Response Regulation Of Double-strand Break Repair Via Homologous Recombination Positive Regulation Of Protein-containing Complex Assembly Regulation Of Establishment Of Protein Localization To Chromosome Cellular Response To Ionizing Radiation Cellular Response To Hydroxyurea Cellular Response To Camptothecin Positive Regulation Of Double-strand Break Repair	Osteoblast Differentiation Male Meiotic Nuclear Division Regulation Of Double-strand Break Repair Via Homologous Recombination Osteoblast Proliferation Negative Regulation Of Apoptotic Process ATP Metabolic Process Microtubule Severing Regulation Of Cell Cycle Cellular Response To Ionizing Radiation Negative Regulation Of Intrinsic Apoptotic Signaling Pathway
Pathways		Resolution of D-loop Structures through Holliday Junction Intermediates	Resolution of D-loop Structures through Holliday Junction Intermediates Meiotic recombination
Drugs
Diseases
GWAS		Heel bone mineral density ( 30598549) Monocyte count ( 32888494) Monocyte percentage of white cells ( 32888494)	Body mass index ( 26426971) Body mass index (age <50) ( 26426971) Body mass index x sex x age interaction (4df test) ( 26426971) Crohn's disease ( 21102463)
Interacting Genes		3 interacting genes: BLM EIF2AK2 FIGNL1	7 interacting genes: DMC1 FIRRM GCC1 IDH1 ITGB1BP1 KDM1A SPIDR
Entrez ID		23514	63979
HPRD ID		19305	10958
Ensembl ID		ENSG00000164808	ENSG00000132436
Uniprot IDs		B3KP42 B4DWT8 Q14159	B3KNH6 Q6PIW4
PDB IDs			3D8B 8R64
Enriched GO Terms of Interacting Partners?		Nuclear Chromosome Cellular Response To Ionizing Radiation Regulation Of DNA Recombination ATP Binding 8-hydroxy-2'-deoxyguanosine DNA Binding Forked DNA-dependent Helicase Activity Telomeric G-quadruplex DNA Binding DNA/DNA Annealing Activity Cellular Response To Radiation RecQ Family Helicase-topoisomerase III Complex Response To Ionizing Radiation Telomeric D-loop Binding Y-form DNA Binding Eukaryotic Translation Initiation Factor 2alpha Kinase Activity Nucleotide Binding Four-way Junction Helicase Activity Cellular Response To Camptothecin Microtubule Severing ATPase Activity DNA Geometric Change Resolution Of DNA Recombination Intermediates ATP Hydrolysis Activity Telomeric D-loop Disassembly Bubble DNA Binding G-quadruplex DNA Binding Telomere Maintenance Via Semi-conservative Replication Microtubule Severing T-circle Formation Cellular Response To Hydroxyurea Response To Hydroxyurea Telomeric Loop Disassembly Response To Radiation Hydrolase Activity, Acting On Acid Anhydrides, In Phosphorus-containing Anhydrides Osteoblast Proliferation 3'-5' DNA Helicase Activity Negative Regulation Of Osteoblast Proliferation Regulation Of DNA Metabolic Process Lateral Element Negative Regulation Of Cell Division Four-way Junction DNA Binding Regulation Of Cellular Response To Stress Regulation Of Hematopoietic Stem Cell Proliferation Regulation Of Hematopoietic Stem Cell Differentiation DNA Conformation Change Positive Regulation Of Stress-activated MAPK Cascade Response To Interferon-alpha DNA Double-strand Break Processing Response To X-ray Perinuclear Region Of Cytoplasm Replication Fork Regulation Of Osteoblast Proliferation	Nucleobase-containing Compound Metabolic Process Regulation Of Phosphorus Metabolic Process Glyoxylate Cycle Isocitrate Metabolic Process Isocitrate Dehydrogenase (NADP+) Activity Negative Regulation Of Cell Adhesion Involved In Substrate-bound Cell Migration Regulation Of Protein Modification Process Negative Regulation Of Protein Targeting To Membrane Blood Vessel Endothelial Cell Proliferation Involved In Sprouting Angiogenesis Recombinational Repair DNA Strand Invasion DNA Metabolic Process DNA Recombinase Assembly Double-strand Break Repair Via Homologous Recombination DNA Repair DNA Strand Exchange Activity Chromosome Catalytic Activity, Acting On DNA Chromosome, Telomeric Region Cell Maturation Regulation Of DNA Recombination Response To Fungicide MRF Binding Regulation Of Double-strand Break Repair Guanine Metabolic Process Protein Demethylase Activity Telomeric Repeat-containing RNA Binding Cellular Response To Radiation Response To Ionizing Radiation Cellular Response To Ionizing Radiation FAD-dependent H3K4me/H3K4me3 Demethylase Activity Regulation Of Double-strand Break Repair Via Homologous Recombination Negative Regulation Of Transcription Initiation-coupled Chromatin Remodeling Cellular Response To Camptothecin Regulation Of Phospholipid Catabolic Process Glyoxylate Metabolic Process Activation Of Protein Kinase B Activity Developmental Maturation DNA Damage Response Histone H3K4 Demethylase Activity Regulation Of Establishment Of Protein Localization To Chromosome Golgi Trans Cisterna Double-strand Break Repair Regulation Of DNA Repair Regulation Of Protein Kinase Activity DNA Recombination Double-strand Break Repair Involved In Meiotic Recombination Histone H3K9 Demethylase Activity Integrin Activation Regulation Of Kinase Activity
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