DAAM2 and TTC3

Number of citations of the paper that reports this interaction (PubMedID 35914814)
83

Data Source:
BioGRID (two hybrid)

		DAAM2	TTC3
Description		dishevelled associated activator of morphogenesis 2	tetratricopeptide repeat domain 3
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Extracellular Exosome	Nucleus Nucleoplasm Nucleolus Cytoplasm Golgi Apparatus Cytosol
	Molecular Function	Actin Binding Protein Binding Small GTPase Binding	Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding Transferase Activity Metal Ion Binding Ubiquitin Protein Ligase Activity
	Biological Process	Determination Of Left/right Symmetry Wnt Signaling Pathway Dorsal Spinal Cord Development Actin Cytoskeleton Organization Positive Regulation Of Cell Migration Regulation Of Actin Filament Polymerization Regulation Of Actin Cytoskeleton Organization Negative Regulation Of Oligodendrocyte Differentiation Regulation Of Filopodium Assembly Regulation Of Canonical Wnt Signaling Pathway Positive Regulation Of Canonical Wnt Signaling Pathway Podocyte Cell Migration Regulation Of Non-canonical Wnt Signaling Pathway	Ubiquitin-dependent Protein Catabolic Process Protein Ubiquitination Protein K48-linked Ubiquitination
Pathways
Drugs
Diseases
GWAS		Appendicular lean mass ( 33097823) Brain morphology (MOSTest) ( 32665545) Heel bone mineral density ( 30598549) Height ( 31562340) Hypospadias ( 25108383) Intraocular pressure ( 29785010) Pulmonary function ( 20010834) Subcortical volume (MOSTest) ( 32665545)	Eye color traits ( 20463881)
Interacting Genes		16 interacting genes: EHHADH EXOSC5 HGS KCNIP1 KRT40 KRTAP10-1 KRTAP10-3 KRTAP10-7 KRTAP10-8 MDFI RBMY1A1 RBMY1F REL TH TIAM1 TTC3	72 interacting genes: AKAP17A AKT1 APP ARID1A ATF7IP ATP2A2 ATP6V0A1 BLOC1S2 CADPS CADPS2 CEP290 CHUK CKAP2 CKAP5 COG4 COPS5 DAAM2 DLEU7 DSP DST EIF4G2 ETS2 EXOC4 FBXO7 FMNL2 FUT8 HARS1 HERC2 HSPB1 IFIT5 JADE2 JAK1 KANSL2 LCOR LRPAP1 MDH1 MIR7-1 MORF4L1 NR1D2 NR1H2 NUFIP1 PAX6 PBX2 PKNOX1 POLG PPFIBP1 PRKDC PSMD7 PSME1 RAI14 SH3BP5 SHROOM2 SMARCA4 SPARCL1 SPTAN1 SPTBN1 STXBP1 TAF1 THOP1 TJP1 TRAF6 TTN UBE2D2 UBE2E3 UBE3A UBR4 USP28 VHL WAC WHAMM XRN2 YWHAE
Entrez ID		23500	7267
HPRD ID		09434	03773
Ensembl ID		ENSG00000146122	ENSG00000182670
Uniprot IDs		A0A0J9YYF7 Q86T65	H7BZ57 P53804
PDB IDs
Enriched GO Terms of Interacting Partners?		Keratin Filament Intermediate Filament Cytosol Positive Regulation Of MRNA Splicing, Via Spliceosome	Positive Regulation Of RNA Biosynthetic Process Protein-containing Complex Cytosol Positive Regulation Of DNA-templated Transcription Positive Regulation Of RNA Metabolic Process Protein Polyubiquitination Positive Regulation Of Nucleobase-containing Compound Metabolic Process Protein Modification By Small Protein Conjugation Regulation Of Cell Cycle G1/S Phase Transition Positive Regulation Of Macromolecule Biosynthetic Process Protein Ubiquitination Post-translational Protein Modification Positive Regulation Of Biosynthetic Process Dense Core Granule Exocytosis Regulation Of G1/S Transition Of Mitotic Cell Cycle Establishment Of Vesicle Localization Protein K48-linked Ubiquitination Vesicle Localization Ubiquitin-protein Transferase Activity Positive Regulation Of Metabolic Process Positive Regulation Of Transcription By RNA Polymerase II Calmodulin Binding Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Protein K11-linked Ubiquitination Organelle Localization Toll-like Receptor 4 Signaling Pathway Regulation Of Autophagy Regulation Of Gene Expression Cell Surface Toll-like Receptor Signaling Pathway Regulation Of Cell Cycle Protein Modification Process Regulation Of Metabolic Process Enzyme Binding Intracellular Receptor Signaling Pathway Regulation Of Macromolecule Biosynthetic Process Cadherin Binding Positive Regulation Of Macromolecule Metabolic Process Protein Localization To Cell-cell Junction Secretory Granule Localization Cell Surface Pattern Recognition Receptor Signaling Pathway Regulation Of Cellular Response To Stress Nucleoplasm Positive Regulation Of Protein Localization Regulation Of Cell Cycle Phase Transition Cell Cortex Regulation Of RNA Metabolic Process Golgi To Plasma Membrane Transport Ubiquitin-dependent Protein Catabolic Process Proteasome Complex
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