QPRT and BCKDK

		QPRT	BCKDK
Description		quinolinate phosphoribosyltransferase	branched chain keto acid dehydrogenase kinase
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GO Annotations	Cellular Component	Cytoplasm Cytosol Extracellular Exosome Catalytic Complex	Mitochondrion Mitochondrial Matrix Oxoglutarate Dehydrogenase Complex
	Molecular Function	Nicotinate-nucleotide Diphosphorylase (carboxylating) Activity Protein Binding Transferase Activity Glycosyltransferase Activity Pentosyltransferase Activity Identical Protein Binding	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Serine/threonine Phosphatase Activity Pyruvate Dehydrogenase (acetyl-transferring) Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Transferase Activity, Transferring Phosphorus-containing Groups [3-methyl-2-oxobutanoate Dehydrogenase (acetyl-transferring)] Kinase Activity Protein Serine Kinase Activity Catalytic Activity, Acting On A Protein
	Biological Process	NAD+ Biosynthetic Process Pyridine Nucleotide Biosynthetic Process NAD+ Metabolic Process Quinolinate Catabolic Process 'de Novo' NAD+ Biosynthetic Process From L-tryptophan Quinolinate Metabolic Process	L-isoleucine Catabolic Process L-leucine Catabolic Process L-valine Catabolic Process Spermatogenesis Lipid Biosynthetic Process Amino Acid Catabolic Process Branched-chain Amino Acid Catabolic Process Regulation Of Pyruvate Decarboxylation To Acetyl-CoA Regulation Of Glucose Metabolic Process
Pathways		Nicotinate metabolism	Branched-chain amino acid catabolism Branched-chain ketoacid dehydrogenase kinase deficiency
Drugs		Niacin	Adenosine 5'-[gamma-thio]triphosphate
Diseases
GWAS			Bipolar disorder ( 31043756) Bipolar I disorder ( 31043756) Parkinson's disease ( 25064009) Systolic blood pressure ( 31928498) Triglyceride levels ( 31928498) Waist circumference ( 31928498)
Interacting Genes		9 interacting genes: ADAMTSL4 GIT2 KRT40 KRTAP1-1 KRTAP10-3 KRTAP10-8 KRTAP4-12 NOTCH2NLA SUFU	11 interacting genes: APP EPS8 FBXO7 FXR1 FXR2 LSM8 NR5A2 SPTA1 STAT3 TRAF4 UBC
Entrez ID		23475	10295
HPRD ID		06950	12523
Ensembl ID		ENSG00000103485	ENSG00000103507
Uniprot IDs		B4DDH4 H3BP73 Q15274 V9HWJ5	O14874
PDB IDs		2JBM 4KWV 4KWW 5AYX 5AYY 5AYZ	8F5F 8F5J 8F5S 9DI9
Enriched GO Terms of Interacting Partners?		Keratin Filament Intermediate Filament [3-methyl-2-oxobutanoate Dehydrogenase (acetyl-transferring)] Kinase Activity Regulation Of Cellular Response To Drug Positive Regulation Of Cellular Response To Drug Pigment Cell Development	Regulation Of Long-term Neuronal Synaptic Plasticity Regulation Of Translation At Presynapse, Modulating Synaptic Transmission Regulation Of Neuronal Synaptic Plasticity Neuron Projection Positive Regulation Of Catabolic Process Regulation Of Developmental Process Positive Regulation Of Small Molecule Metabolic Process Positive Regulation Of Long-term Neuronal Synaptic Plasticity Negative Regulation Of Long-term Synaptic Potentiation Regulation Of Purine Nucleotide Metabolic Process Regulation Of Stem Cell Differentiation Translation Regulator Activity Positive Regulation Of JNK Cascade Regulation Of Cell Differentiation Positive Regulation Of Protein Metabolic Process Regulation Of Intracellular Signal Transduction Positive Regulation Of MRNA Catabolic Process Regulation Of Biological Quality Stem Cell Population Maintenance Maintenance Of Cell Number Ubiquitin Protein Ligase Binding Regulation Of MiRNA-mediated Gene Silencing Dentate Gyrus Development Positive Regulation Of Phosphate Metabolic Process Regulation Of Post-transcriptional Gene Silencing Regulation Of Reactive Oxygen Species Metabolic Process Regulation Of Small Molecule Metabolic Process Regulation Of Cell Shape Regulation Of JNK Cascade Post-transcriptional Regulation Of Gene Expression Protein Heterodimerization Activity Actin Filament Capping Positive Regulation Of MRNA Metabolic Process Cytoplasmic Translational Initiation Amyloid-beta Complex Axon Growth Cone Lamellipodium Regulation Of Response To Calcium Ion Regulation Of Tumor Necrosis Factor Production Amylin Binding Positive Regulation Of ATP Metabolic Process Positive Regulation Of Toll Signaling Pathway Regulation Of Long-term Synaptic Potentiation Negative Regulation Of Actin Filament Depolymerization Temperature Homeostasis Regulation Of Stress-activated Protein Kinase Signaling Cascade Regulation Of Stress-activated MAPK Cascade Zygotic Genome Activation Positive Regulation Of Guanylate Cyclase Activity Presynaptic Modulation Of Chemical Synaptic Transmission
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