GPR161 and SLC30A2

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		GPR161	SLC30A2
Description		G protein-coupled receptor 161	solute carrier family 30 member 2
Image			No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Cilium Membrane Endocytic Vesicle Membrane Cell Projection Recycling Endosome Ciliary Membrane	Cytoplasm Mitochondrion Mitochondrial Inner Membrane Lysosome Lysosomal Membrane Endosome Late Endosome Plasma Membrane Endosome Membrane Membrane Transport Vesicle Membrane Cytoplasmic Vesicle Zymogen Granule Membrane Secretory Vesicle
	Molecular Function	G Protein-coupled Receptor Activity Protein Binding	Zinc Ion Transmembrane Transporter Activity Protein Binding Monoatomic Cation Transmembrane Transporter Activity Antiporter Activity Identical Protein Binding Metal Ion Binding Zinc:proton Antiporter Activity
	Biological Process	Signal Transduction G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Negative Regulation Of Smoothened Signaling Pathway Involved In Dorsal/ventral Neural Tube Patterning	Monoatomic Ion Transport Monoatomic Cation Transport Zinc Ion Transport Intracellular Zinc Ion Homeostasis Response To Zinc Ion Transmembrane Transport Zinc Ion Import Into Organelle Zinc Ion Transmembrane Transport Zinc Export Across Plasma Membrane Zinc Ion Import Into Secretory Vesicle Zinc Ion Import Into Zymogen Granule Zinc Ion Import Into Lysosome Zinc Ion Import Into Mitochondrion
Pathways		Hedgehog 'off' state Hedgehog 'on' state	Zinc efflux and compartmentalization by the SLC30 family
Drugs
Diseases
GWAS		Red cell distribution width ( 27863252)
Interacting Genes		8 interacting genes: CCR2 CLDN19 COMT CREBBP EFNA5 GPR35 SLC30A2 UPK1B	67 interacting genes: ABHD16A ADAM33 AQP2 AQP6 ATP13A1 C5orf46 CCL4 CCL4L2 CD40 CD52 CD79A CD99L2 CPLX4 CREB3 CTSA CYB561D2 EBAG9 EMP3 ERGIC3 EVI2B F11R FAM174A FDPS FFAR2 FXYD3 FXYD6 GALNT15 GJA5 GJB2 GJB5 GLB1 GOLT1A GPR161 GPR42 GPRC5D HGFAC KASH5 KCNN4 LMNA LTA LYVE1 MS4A13 NDUFAF1 NRM OPRM1 PCNX2 PLPPR1 PVR SEC22A SELL SERPING1 SLC10A6 SLC16A2 SLC18A1 SLC38A7 SLC39A2 SLC7A1 SLC7A8 TAS2R5 TM4SF18 TMEM107 TMEM52B TMEM60 TMEM86A TNFRSF12A TRARG1 YIPF2
Entrez ID		23432	7780
HPRD ID		17070	18057
Ensembl ID		ENSG00000143147	ENSG00000158014
Uniprot IDs		A0A0A0MQW8 Q8N6U8	Q9BRI3
PDB IDs		8KH4 8SMV
Enriched GO Terms of Interacting Partners?		Norepinephrine Secretion Renal Absorption Catechol O-methyltransferase Activity Neurotrophin TRKC Receptor Binding Neurotrophin TRKB Receptor Binding Chemokine Receptor Activity Zinc Ion Import Into Zymogen Granule Zinc Ion Import Into Mitochondrion Zinc Ion Import Into Secretory Vesicle Negative Regulation Of Eosinophil Degranulation Positive Regulation Of Astrocyte Chemotaxis T-helper 17 Cell Chemotaxis Chemokine (C-C Motif) Ligand 12 Binding Chemokine (C-C Motif) Ligand 2 Binding Cellular Response To Phosphate Starvation Regulation Of Biological Quality Histone H3K27 Acetyltransferase Activity Chemokine-mediated Signaling Pathway Mesaxon Positive Regulation Of Immune Complex Clearance By Monocytes And Macrophages Positive Regulation Of Thymocyte Migration Positive Regulation Of CD8-positive, Alpha-beta T Cell Extravasation Chemokine (C-C Motif) Ligand 7 Binding Positive Regulation Of Hematopoietic Stem Cell Migration Regulation Of Astrocyte Chemotaxis Habituation Mastication Renal Sodium Excretion Renal Albumin Absorption Renin Secretion Into Blood Stream Renal System Process Histone H3K18 Acetyltransferase Activity N-terminal Peptidyl-lysine Acetylation Peptide Lactyltransferase (CoA-dependent) Activity Cell-cell Adhesion Apical Plasma Membrane Urothelial Plaque Zinc Ion Import Into Lysosome Zinc Export Across Plasma Membrane Regulation Of Transepithelial Transport CCR2 Chemokine Receptor Binding Regulation Of Thymocyte Migration Positive Regulation Of T Cell Extravasation Regulation Of Immune Complex Clearance By Monocytes And Macrophages Cerebellar Cortex Morphogenesis MRF Binding Zinc:proton Antiporter Activity Positive Regulation Of Monocyte Extravasation Monocyte Extravasation Positive Regulation Of Cytosolic Calcium Ion Concentration Dopamine Secretion	Membrane Transmembrane Transport Plasma Membrane Connexin Complex Gap Junction Channel Activity Gap Junction Renal Water Transport Gap Junction Assembly Positive Regulation Of Sodium Ion Export Across Plasma Membrane Ion Channel Regulator Activity CCR1 Chemokine Receptor Binding Amino Acid Import Across Plasma Membrane Amino Acid Transmembrane Transporter Activity Amino Acid Transmembrane Transport Thyroid Hormone Transmembrane Transporter Activity Metal Ion Transport Protein Binding Positive Regulation Of Immune System Process Monoatomic Cation Transport Aromatic Amino Acid Transport
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