GPR161

Description		G protein-coupled receptor 161
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GO Annotations	Cellular Component	Plasma Membrane Cilium Membrane Endocytic Vesicle Membrane Cell Projection Recycling Endosome Ciliary Membrane
	Molecular Function	G Protein-coupled Receptor Activity Protein Binding
	Biological Process	Signal Transduction G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Negative Regulation Of Smoothened Signaling Pathway Involved In Dorsal/ventral Neural Tube Patterning
Pathways		Hedgehog 'off' state Hedgehog 'on' state
Drugs
Diseases
GWAS		Red cell distribution width ( 27863252)
Novel Interacting Genes		1 novel interacting genes: TOR1AIP1
Interacting Genes		8 interacting genes: CCR2 CLDN19 COMT CREBBP EFNA5 GPR35 SLC30A2 UPK1B
Entrez ID		23432
HPRD ID		17070
Ensembl ID		ENSG00000143147
Uniprot IDs		A0A0A0MQW8 Q8N6U8
PDB IDs		8KH4 8SMV
Enriched GO Terms of Interacting Partners?		Norepinephrine Secretion Renal Absorption Catechol O-methyltransferase Activity Neurotrophin TRKC Receptor Binding Neurotrophin TRKB Receptor Binding Chemokine Receptor Activity Zinc Ion Import Into Zymogen Granule Zinc Ion Import Into Mitochondrion Zinc Ion Import Into Secretory Vesicle Negative Regulation Of Eosinophil Degranulation Positive Regulation Of Astrocyte Chemotaxis T-helper 17 Cell Chemotaxis Chemokine (C-C Motif) Ligand 12 Binding Chemokine (C-C Motif) Ligand 2 Binding Cellular Response To Phosphate Starvation Regulation Of Biological Quality Histone H3K27 Acetyltransferase Activity Chemokine-mediated Signaling Pathway Mesaxon Positive Regulation Of Immune Complex Clearance By Monocytes And Macrophages Positive Regulation Of Thymocyte Migration Positive Regulation Of CD8-positive, Alpha-beta T Cell Extravasation Chemokine (C-C Motif) Ligand 7 Binding Positive Regulation Of Hematopoietic Stem Cell Migration Regulation Of Astrocyte Chemotaxis Habituation Mastication Renal Sodium Excretion Renal Albumin Absorption Renin Secretion Into Blood Stream Renal System Process Histone H3K18 Acetyltransferase Activity N-terminal Peptidyl-lysine Acetylation Peptide Lactyltransferase (CoA-dependent) Activity Cell-cell Adhesion Apical Plasma Membrane Urothelial Plaque Zinc Ion Import Into Lysosome Zinc Export Across Plasma Membrane Regulation Of Transepithelial Transport CCR2 Chemokine Receptor Binding Regulation Of Thymocyte Migration Positive Regulation Of T Cell Extravasation Regulation Of Immune Complex Clearance By Monocytes And Macrophages Cerebellar Cortex Morphogenesis MRF Binding Zinc:proton Antiporter Activity Positive Regulation Of Monocyte Extravasation Monocyte Extravasation Positive Regulation Of Cytosolic Calcium Ion Concentration Dopamine Secretion
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