GPR161 and EFNA5

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		GPR161	EFNA5
Description		G protein-coupled receptor 161	ephrin A5
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GO Annotations	Cellular Component	Plasma Membrane Cilium Membrane Endocytic Vesicle Membrane Cell Projection Recycling Endosome Ciliary Membrane	Basement Membrane Plasma Membrane Caveola Adherens Junction External Side Of Plasma Membrane Membrane Cell Periphery Side Of Membrane GABA-ergic Synapse
	Molecular Function	G Protein-coupled Receptor Activity Protein Binding	Neurotrophin TRKA Receptor Binding Neurotrophin TRKB Receptor Binding Neurotrophin TRKC Receptor Binding Protein Binding Transmembrane Receptor Protein Tyrosine Kinase Activator Activity Chemorepellent Activity Ephrin Receptor Binding
	Biological Process	Signal Transduction G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Negative Regulation Of Smoothened Signaling Pathway Involved In Dorsal/ventral Neural Tube Patterning	Apoptotic Process Nervous System Development Axon Guidance Regulation Of Cell-cell Adhesion Regulation Of Cell Morphogenesis Cell Differentiation Retinal Ganglion Cell Axon Guidance Regulation Of Actin Cytoskeleton Organization Regulation Of GTPase Activity Ephrin Receptor Signaling Pathway Collateral Sprouting Positive Regulation Of Collateral Sprouting Positive Regulation Of Peptidyl-tyrosine Phosphorylation Negative Chemotaxis Regulation Of Focal Adhesion Assembly Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Positive Regulation Of Synapse Assembly Regulation Of Insulin Secretion Involved In Cellular Response To Glucose Stimulus Regulation Of Microtubule Cytoskeleton Organization Cellular Response To Follicle-stimulating Hormone Stimulus Synaptic Membrane Adhesion Negative Regulation Of Substrate Adhesion-dependent Cell Spreading Cellular Response To Forskolin
Pathways		Hedgehog 'off' state Hedgehog 'on' state	EPH-Ephrin signaling EPH-Ephrin signaling EPHA-mediated growth cone collapse EPHA-mediated growth cone collapse EPH-ephrin mediated repulsion of cells EPH-ephrin mediated repulsion of cells
Drugs
Diseases
GWAS		Red cell distribution width ( 27863252)	Adult body size ( 32376654) Age at first sexual intercourse ( 34211149) Alanine aminotransferase levels ( 34315874 33547301) Alzheimer's disease biomarkers ( 23419831) Aspartate aminotransferase levels ( 34315874) Atrial fibrillation ( 29892015) Body mass index ( 26426971) Chronotype ( 30696823) Cocaine dependence ( 31212010) Cognitive ability, years of educational attainment or schizophrenia (pleiotropy) ( 31374203) Daytime nap ( 33568662) Dentures ( 31235808) Hippocampal atrophy ( 19668339) Household income (MTAG) ( 31844048) Liver enzyme levels (gamma-glutamyl transferase) ( 33972514) Longitudinal cocaine use ( 31591132) Medial orbital frontal cortex volume ( 31530798) Metabolite levels ( 23823483) Moderate-to-late spontaneous preterm birth ( 31194736) Neonatal cytokine/chemokine levels (maternal genetic effect) ( 30134952) Non-del(5q) myelodysplastic syndromes ( 31738830) Nose morphology ( 29921221) Number of children ever born ( 27798627) Number of decayed, missing and filled tooth surfaces or use of dentures ( 31235808) Sedentary behaviour duration ( 30531941) Smoking initiation (ever regular vs never regular) ( 30679032) Smoking status (ever vs never smokers) ( 30643258)
Interacting Genes		8 interacting genes: CCR2 CLDN19 COMT CREBBP EFNA5 GPR35 SLC30A2 UPK1B	38 interacting genes: ACKR2 AQP2 AQP6 BEST2 CD53 CLDN5 CYB561 EPHA2 EPHA3 EPHA4 EPHA5 EPHA7 EPHA8 EPHB1 EPHB2 FFAR3 GJB1 GPR151 GPR152 GPR161 GPR42 GRIP1 HERPUD2 HIBADH KASH5 MS4A3 SGPL1 SLC10A2 SLC13A4 SLC16A2 SLC35H1 SRC SSMEM1 TM4SF18 TMEM237 TRHR TSPO2 YIPF6
Entrez ID		23432	1946
HPRD ID		17070	03324
Ensembl ID		ENSG00000143147	ENSG00000184349
Uniprot IDs		A0A0A0MQW8 Q8N6U8	D6RDV5 P52803
PDB IDs		8KH4 8SMV	2X11 3MX0 4BK5 4BKA 4L0P 4M4R
Enriched GO Terms of Interacting Partners?		Norepinephrine Secretion Renal Absorption Catechol O-methyltransferase Activity Neurotrophin TRKC Receptor Binding Neurotrophin TRKB Receptor Binding Chemokine Receptor Activity Zinc Ion Import Into Zymogen Granule Zinc Ion Import Into Mitochondrion Zinc Ion Import Into Secretory Vesicle Negative Regulation Of Eosinophil Degranulation Positive Regulation Of Astrocyte Chemotaxis T-helper 17 Cell Chemotaxis Chemokine (C-C Motif) Ligand 12 Binding Chemokine (C-C Motif) Ligand 2 Binding Cellular Response To Phosphate Starvation Regulation Of Biological Quality Histone H3K27 Acetyltransferase Activity Chemokine-mediated Signaling Pathway Mesaxon Positive Regulation Of Immune Complex Clearance By Monocytes And Macrophages Positive Regulation Of Thymocyte Migration Positive Regulation Of CD8-positive, Alpha-beta T Cell Extravasation Chemokine (C-C Motif) Ligand 7 Binding Positive Regulation Of Hematopoietic Stem Cell Migration Regulation Of Astrocyte Chemotaxis Habituation Mastication Renal Sodium Excretion Renal Albumin Absorption Renin Secretion Into Blood Stream Renal System Process Histone H3K18 Acetyltransferase Activity N-terminal Peptidyl-lysine Acetylation Peptide Lactyltransferase (CoA-dependent) Activity Cell-cell Adhesion Apical Plasma Membrane Urothelial Plaque Zinc Ion Import Into Lysosome Zinc Export Across Plasma Membrane Regulation Of Transepithelial Transport CCR2 Chemokine Receptor Binding Regulation Of Thymocyte Migration Positive Regulation Of T Cell Extravasation Regulation Of Immune Complex Clearance By Monocytes And Macrophages Cerebellar Cortex Morphogenesis MRF Binding Zinc:proton Antiporter Activity Positive Regulation Of Monocyte Extravasation Monocyte Extravasation Positive Regulation Of Cytosolic Calcium Ion Concentration Dopamine Secretion	Ephrin Receptor Activity Ephrin Receptor Signaling Pathway Transmembrane-ephrin Receptor Activity Membrane Transmembrane Receptor Protein Tyrosine Kinase Activity GPI-linked Ephrin Receptor Activity Protein Tyrosine Kinase Activity Plasma Membrane Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Enzyme-linked Receptor Protein Signaling Pathway Neuron Projection Guidance Axon Guidance Protein Kinase Activity Regulation Of Cell Junction Assembly Axon Guidance Receptor Activity Fasciculation Of Motor Neuron Axon Kinase Activity Dendrite Axonal Fasciculation Neuron Projection Fasciculation Retinal Ganglion Cell Axon Guidance Fasciculation Of Sensory Neuron Axon G Protein-coupled Receptor Activity Central Nervous System Projection Neuron Axonogenesis Ephrin Receptor Binding Regulation Of ERK1 And ERK2 Cascade Optic Nerve Morphogenesis Hindbrain Tangential Cell Migration Central Nervous System Neuron Axonogenesis Signal Transduction Neuron Projection Development Channel Activity Positive Regulation Of Cell Junction Assembly Cell Migration Renal Water Transport Nephric Duct Morphogenesis Growth Factor Binding Neuron Recognition Cell Recognition Peptidyl-tyrosine Phosphorylation Positive Regulation Of Bicellular Tight Junction Assembly Intestinal Epithelial Cell Development Cell Surface Receptor Signaling Pathway Nervous System Development Anchoring Junction Regulation Of GTPase Activity G Protein-coupled Receptor Signaling Pathway Cell Migration In Hindbrain Cell Motility Water Channel Activity
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