NCAPD3 and PRSS23

Number of citations of the paper that reports this interaction (PubMedID 16169070)
0

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		NCAPD3	PRSS23
Description		non-SMC condensin II complex subunit D3	serine protease 23
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Chromosome, Centromeric Region Condensed Chromosome, Centromeric Region Condensed Nuclear Chromosome Condensin Complex Nucleus Nucleoplasm Pericentric Heterochromatin Membrane Nuclear Lumen	Extracellular Region Nucleus Endoplasmic Reticulum Lumen Extracellular Exosome
	Molecular Function	Protein Binding Histone Binding Histone H4K20me1 Reader Activity	Serine-type Endopeptidase Activity Protein Binding Peptidase Activity Serine-type Peptidase Activity Hydrolase Activity
	Biological Process	Nuclear Division Chromatin Organization Mitotic Chromosome Condensation Meiotic Chromosome Condensation Chromosome Condensation Cell Division Positive Regulation Of Chromosome Segregation Nuclear Chromosome Segregation Positive Regulation Of Chromosome Separation Positive Regulation Of Chromosome Condensation	Proteolysis
Pathways		Condensation of Prophase Chromosomes	Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Post-translational protein phosphorylation
Drugs
Diseases
GWAS		Cognitive test performance ( 17903297) Metabolite levels ( 23823483) Verbal declarative memory ( 25648963)	Blood urea nitrogen levels ( 31152163) Chronic obstructive pulmonary disease ( 30804561) FEV1 ( 30804560) Heel bone mineral density ( 28869591 30598549) Intraocular pressure ( 29617998 29785010) Lung function (FEV1) ( 28166213) Lung function (FEV1/FVC) ( 30804560) Peak expiratory flow ( 30804560)
Interacting Genes		6 interacting genes: CDK1 CEBPA PLK1 PRSS23 SUMO2 TEKT1	27 interacting genes: ACTG1 APP B2M CHP1 EFNA3 FXR1 GATD1 GRK6 HSPA4 MAPK8IP2 NCAPD3 NIPBL NOC4L ODF2L PDPK1 PHF23 PPIA RACGAP1 RECQL4 RPL4P5 SEC11C SHMT1 SLC25A6 TCF12 TMEM222 TRAPPC4 UBC
Entrez ID		23310	11098
HPRD ID		11062	07149
Ensembl ID		ENSG00000151503	ENSG00000150687
Uniprot IDs		A0A8I5KT00 P42695	O95084
PDB IDs
Enriched GO Terms of Interacting Partners?		Mitotic Nuclear Membrane Disassembly Membrane Disassembly Nuclear Membrane Disassembly Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Proteolysis Involved In Protein Catabolic Process Positive Regulation Of Proteasomal Protein Catabolic Process Regulation Of Ubiquitin-dependent Protein Catabolic Process Protein Localization To Site Of Double-strand Break Positive Regulation Of Proteolysis Regulation Of Proteasomal Protein Catabolic Process Positive Regulation Of Protein Catabolic Process Mitotic G2 DNA Damage Checkpoint Signaling Chromosome Condensation Spindle Microtubule Nuclear Membrane Organization Centrosome Cycle Mitotic G2/M Transition Checkpoint G2/M Transition Of Mitotic Cell Cycle Cell Cycle G2/M Phase Transition Negative Regulation Of Cell Cycle Negative Regulation Of Cell Cycle G2/M Phase Transition Mitotic DNA Integrity Checkpoint Signaling Negative Regulation Of G2/M Transition Of Mitotic Cell Cycle Mitotic DNA Damage Checkpoint Signaling Regulation Of Protein Catabolic Process Regulation Of Proteolysis Pronuclear Fusion RNA Polymerase I Transcription Regulatory Region Sequence-specific DNA Binding Microtubule Organizing Center Organization Protein Localization To Chromosome Mitotic DNA-templated DNA Replication Regulation Of G2/M Transition Of Mitotic Cell Cycle Regulation Of Sister Chromatid Segregation Cyclin B1-CDK1 Complex Cyclin A1-CDK1 Complex Cyclin A2-CDK1 Complex Positive Regulation Of Protein Localization To Nucleus DNA Damage Checkpoint Signaling Response To Vitamin B2 C/EBP Complex Synaptonemal Complex Disassembly Golgi Inheritance GABA-ergic Synapse Golgi Organization Regulation Of Cell Cycle G2/M Phase Transition Mitotic DNA Replication DNA Synthesis Involved In Mitotic DNA Replication Microtubule Cytoskeleton Organization Involved In Mitosis
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