FMO1 and REEP4

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		FMO1	REEP4
Description		flavin containing dimethylaniline monoxygenase 1	receptor accessory protein 4
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Endoplasmic Reticulum Endoplasmic Reticulum Lumen Endoplasmic Reticulum Membrane Membrane	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Microtubule Cytoplasmic Microtubule Membrane Endoplasmic Reticulum Tubular Network
	Molecular Function	Monooxygenase Activity N,N-dimethylaniline Monooxygenase Activity Protein Binding Oxidoreductase Activity Trimethylamine Monooxygenase Activity Hypotaurine Monooxygenase Activity Flavin Adenine Dinucleotide Binding NADP Binding	Protein Binding Microtubule Binding
	Biological Process	Sulfur Amino Acid Catabolic Process Organic Acid Metabolic Process Xenobiotic Metabolic Process Toxin Metabolic Process Response To Lipopolysaccharide Taurine Biosynthetic Process Negative Regulation Of Fatty Acid Oxidation Energy Homeostasis	Nuclear Envelope Organization Mitotic Nuclear Membrane Reassembly Cell Division Endoplasmic Reticulum Tubular Network Organization
Pathways		Degradation of cysteine and homocysteine FMO oxidises nucleophiles
Drugs
Diseases
GWAS		Metabolite levels ( 23823483) Sudden cardiac arrest ( 21658281) Type 2 diabetes (age of onset) ( 28060188)	Frailty index ( 34431594) Hypertriglyceridemia ( 23505323)
Interacting Genes		7 interacting genes: CREB3 GRINA LEPROTL1 REEP4 SLC10A6 SLC71A2 TLN1	101 interacting genes: AGPAT4 ARLN BCL2L1 BET1 BIK BMP10 C14orf180 C1S C2CD2L CCL4L2 CLDND2 CMTM3 COMT CTSA CYB5B CYB5R3 CYP4F2 DCBLD2 DERL1 DGAT2L6 DNAJC30 ERG28 FAM241B FBXO7 FMO1 FUNDC2 GIMAP1 GYPB HSD3B7 HTATIP2 IFITM3 ITGAM LEMD1 LEMD3 LEPROTL1 LNPEP MAL2 MOSPD3 MS4A1 NCK2 NINJ2 ORMDL1 PEX16 PLP2 PMP22 PRAF2 RTP2 RTP4 SEC22B SELENOK SELENOM SERF1A SERF1B SERP1 SFT2D1 SFT2D2 SFXN2 SFXN3 SLC25A46 SLC30A8 SLC7A8 SMAGP SMIM1 SQLE STATH STX3 STX5 SYNJ2BP TIMM22 TMEM120B TMEM121 TMEM128 TMEM14B TMEM167B TMEM18 TMEM19 TMEM208 TMEM229B TMEM254 TMEM42 TMEM50A TMEM51 TMEM60 TMEM65 TMEM86A TMX2 TPRG1 TSNARE1 TSPAN2 TVP23B UBE2J1 UBIAD1 UNC50 VAMP1 VAMP4 VAPB VMA12 VTI1B YIF1A YIPF4 YIPF6
Entrez ID		2326	80346
HPRD ID		00631	09864
Ensembl ID		ENSG00000010932	ENSG00000168476
Uniprot IDs		B2RCG5 Q01740	E5RGS2 Q9H6H4
PDB IDs
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway Negative Regulation Of Response To Endoplasmic Reticulum Stress Positive Regulation Of Deacetylase Activity Sodium-dependent Organic Anion Transmembrane Transporter Activity Sodium-dependent Organic Anion Transport Membrane Regulation Of Response To Endoplasmic Reticulum Stress Negative Regulation Of Intrinsic Apoptotic Signaling Pathway	Membrane Endoplasmic Reticulum Membrane Endoplasmic Reticulum Endomembrane System SNAP Receptor Activity SNARE Complex Protein Binding Establishment Of Protein Localization Organelle Fusion Vesicle Fusion Organelle Membrane Fusion Mitochondrial Outer Membrane Membrane Fusion Membrane Organization Vesicle Fusion With Golgi Apparatus Endoplasmic Reticulum To Golgi Vesicle-mediated Transport Vesicle-mediated Transport Membrane Docking Protein Transport Presynaptic Endosome Membrane Golgi Vesicle Transport Monoatomic Ion Transmembrane Transporter Activity Intracellular Transport Cellular Localization Mitochondrial Membrane Nitric-oxide Synthase Complex Vesicle Organization Organelle Localization By Membrane Tethering Endoplasmic Reticulum-Golgi Intermediate Compartment Membrane Serine Import Into Mitochondrion Olfactory Receptor Binding Establishment Of Localization In Cell Myelination Axon Ensheathment Nitrite Reductase (NO-forming) Activity Transport Vesicle Golgi Membrane Vesicle Docking Menaquinone Metabolic Process SNARE Binding Golgi Organization Import Into The Mitochondrion Bcl-2 Family Protein Complex Mitochondrial Transport
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