SCFD1 and HECTD1

		SCFD1	HECTD1
Description		sec1 family domain containing 1	HECT domain E3 ubiquitin protein ligase 1
Image		No pdb structure
GO Annotations	Cellular Component	Golgi Membrane Cytoplasm Endoplasmic Reticulum Endoplasmic Reticulum Membrane Golgi Apparatus Golgi-associated Vesicle Cis-Golgi Network Cytosol Membrane Golgi Cisterna Membrane
	Molecular Function	Protein Binding Syntaxin Binding Protein-containing Complex Binding	Ubiquitin-protein Transferase Activity Protein Binding Transferase Activity Metal Ion Binding Ubiquitin Protein Ligase Activity
	Biological Process	Intracellular Protein Transport Endoplasmic Reticulum To Golgi Vesicle-mediated Transport Retrograde Vesicle-mediated Transport, Golgi To Endoplasmic Reticulum Post-Golgi Vesicle-mediated Transport Response To Toxic Substance Protein Transport Vesicle-mediated Transport Regulation Of Protein Transport Regulation Of ER To Golgi Vesicle-mediated Transport Negative Regulation Of Autophagosome Assembly	Heart Valve Development Ventricular Septum Development Ubiquitin-dependent Protein Catabolic Process Protein Ubiquitination Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Aorta Development
Pathways		COPII-mediated vesicle transport RHOA GTPase cycle	Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS		Amyotrophic lateral sclerosis ( 27455348 29566793) Cognitive decline (age-related) ( 28078323) Mean spheric corpuscular volume ( 32888494) Metabolite levels ( 23823483) Night sleep phenotypes ( 27126917)
Interacting Genes		5 interacting genes: DLST PPBP STX5 USO1 USP22	9 interacting genes: HRAS IGSF1 MTNR1B NRIP1 UBE2D1 UBE2D2 UBE2D3 UBE2L3 YWHAG
Entrez ID		23256	25831
HPRD ID		10210	17098
Ensembl ID		ENSG00000092108	ENSG00000092148
Uniprot IDs		A0A7I2V590 B7Z5N7 B7Z738 H0YIZ7 Q8WVM8	A0A087X2H1 A0A8I5QJU2 H0YJD4 Q9ULT8
PDB IDs			2DK3 2LC3 3DKM
Enriched GO Terms of Interacting Partners?		Dihydrolipoyllysine-residue Succinyltransferase Activity ER To Golgi Transport Vesicle Membrane Vesicle Docking Organelle Localization By Membrane Tethering Membrane Docking Golgi Vesicle Docking Vesicle Fusion Organelle Membrane Fusion Golgi Organization Endoplasmic Reticulum To Golgi Vesicle-mediated Transport Organelle Fusion L-lysine Catabolic Process To Acetyl-CoA Via Saccharopine Oxoadipate Dehydrogenase Complex L-lysine Catabolic Process Membrane Fusion Histone H2B Deubiquitinase Activity Lysine Catabolic Process Oxoglutarate Dehydrogenase Complex Golgi Disassembly Positive Regulation Of Protein Catabolic Process Vesicle Fusion With Golgi Apparatus Histone H2A Deubiquitinase Activity Succinyl-CoA Metabolic Process D-glucose Transmembrane Transporter Activity Golgi Vesicle Transport Histone H4 Acetyltransferase Activity Amide Catabolic Process CXCR Chemokine Receptor Binding Vesicle Organization Cadherin Binding 2-oxoglutarate Metabolic Process Platelet Alpha Granule Early Endosome To Golgi Transport Regulation Of Golgi Organization Bounding Membrane Of Organelle Regulation Of Protein Catabolic Process Transcytosis Transcription Factor TFTC Complex	Ubiquitin Conjugating Enzyme Activity Protein Polyubiquitination Regulation Of Establishment Of Protein Localization Regulation Of Protein Localization Modification-dependent Protein Catabolic Process Ubiquitin-protein Transferase Activity Ubiquitin-dependent Protein Catabolic Process Protein Ubiquitination Protein K48-linked Ubiquitination Proteolysis Involved In Protein Catabolic Process Protein Modification By Small Protein Conjugation Post-translational Protein Modification Protein K6-linked Ubiquitination Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Positive Regulation Of Protein Targeting To Mitochondrion Positive Regulation Of Establishment Of Protein Localization To Mitochondrion Macromolecule Catabolic Process Protein K11-linked Ubiquitination Regulation Of Protein Targeting To Mitochondrion Proteolysis Ovarian Follicle Rupture Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway TORC1 Signaling Negative Regulation Of TORC1 Signaling Negative Regulation Of BMP Signaling Pathway Protein Autoubiquitination Positive Regulation Of Establishment Of Protein Localization Negative Regulation Of Signal Transduction GTPase Complex Activin Receptor Antagonist Activity Ubiquitin Protein Ligase Activity TOR Signaling Negative Regulation Of Cell Communication Negative Regulation Of Signaling Negative Regulation Of TOR Signaling Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Regulation Of TORC1 Signaling Phospholipase C Activator Activity Protein Kinase C Inhibitor Activity Positive Regulation Of Protein Ubiquitination Protein Modification Process Regulation Of BMP Signaling Pathway Inhibin Binding Melatonin Receptor Activity Positive Regulation Of Circadian Sleep/wake Cycle, Non-REM Sleep Nucleotide Binding Negative Regulation Of Cellular Response To Growth Factor Stimulus Positive Regulation Of Post-translational Protein Modification Proteasomal Protein Catabolic Process Regulation Of Neuronal Action Potential
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