SCFD1 and USP22

Number of citations of the paper that reports this interaction (PMID 16169070)
531

Data Source:
BioGRID (two hybrid)

		SCFD1	USP22
Gene Name		sec1 family domain containing 1	ubiquitin specific peptidase 22
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Endoplasmic Reticulum Membrane Golgi-associated Vesicle Cis-Golgi Network Plasma Membrane Golgi Transport Complex SNARE Complex Golgi Cisterna Membrane	SAGA Complex SAGA-type Complex
	Molecular Function	Protein Binding Syntaxin Binding Protein N-terminus Binding	Transcription Coactivator Activity Cysteine-type Endopeptidase Activity Ubiquitin-specific Protease Activity Protein Binding Zinc Ion Binding H4 Histone Acetyltransferase Activity Enzyme Binding Ligand-dependent Nuclear Receptor Transcription Coactivator Activity
	Biological Process	Cell Morphogenesis Response To Hypoxia Retrograde Vesicle-mediated Transport, Golgi To ER Post-Golgi Vesicle-mediated Transport Vesicle Docking Involved In Exocytosis Phagocytosis Response To Toxic Substance Protein Transport Regulation Of Protein Transport Regulation Of ER To Golgi Vesicle-mediated Transport Negative Regulation Of Autophagic Vacuole Assembly	Chromatin Organization Transcription, DNA-templated Cell Cycle Embryo Development Histone Ubiquitination Histone Deubiquitination Protein Deubiquitination Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Histone H4 Acetylation Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Mitotic Cell Cycle Regulation Of Proteasomal Protein Catabolic Process
Pathways			Chromatin modifying enzymes Chromatin organization HATs acetylate histones
Drugs
Diseases
GWAS
Protein-Protein Interactions		5 interactors: DLST PPBP STX5 USO1 USP22	9 interactors: AASDHPPT HEXA HIST2H2AC HIST2H2BE MRPL10 MRPL44 PSME1 SCFD1 UBC
Entrez ID		23256	23326
HPRD ID		10210	19411
Ensembl ID		ENSG00000092108	ENSG00000124422
Uniprot IDs		Q8WVM8	Q9UPT9
PDB IDs
Enriched GO Terms of Interacting Partners?		Vesicle Fusion With Golgi Apparatus Vesicle Fusion Organelle Fusion Vesicle Docking Membrane Docking ER To Golgi Vesicle-mediated Transport Membrane Fusion Golgi Vesicle Docking Golgi Disassembly L-lysine Catabolic Process To Acetyl-CoA Via Saccharopine Vesicle Organization Golgi Vesicle Transport Golgi Inheritance Regulation Of Golgi Organization Lysine Catabolic Process Vesicle-mediated Transport Early Endosome To Golgi Transport Regulation Of Protein Catabolic Process Transcytosis Leukocyte Migration Involved In Inflammatory Response Histone Deubiquitination Acetyl-CoA Metabolic Process Establishment Of Localization In Cell Hexose Transmembrane Transport Histone Ubiquitination Cytoplasmic Transport Organelle Disassembly	Negative Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Cell Cycle Arrest Signal Transduction Involved In Mitotic G1 DNA Damage Checkpoint Positive Regulation Of Ubiquitin-protein Ligase Activity Involved In Regulation Of Mitotic Cell Cycle Transition Signal Transduction Involved In DNA Damage Checkpoint Signal Transduction Involved In Cell Cycle Checkpoint Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle Negative Regulation Of Ubiquitin-protein Transferase Activity Mitochondrial Translational Elongation Mitochondrial Translational Initiation Mitochondrial Translational Termination Anaphase-promoting Complex-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Mitotic G1 DNA Damage Checkpoint Positive Regulation Of Ubiquitin-protein Transferase Activity Mitotic G1/S Transition Checkpoint G1 DNA Damage Checkpoint Positive Regulation Of Cell Cycle Arrest Positive Regulation Of Ligase Activity DNA Damage Response, Signal Transduction By P53 Class Mediator Mitochondrial Translation Positive Regulation Of Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Regulation Of Ubiquitin-protein Transferase Activity Regulation Of Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Signal Transduction In Response To DNA Damage Mitotic DNA Damage Checkpoint Regulation Of Cell Cycle Arrest Mitotic DNA Integrity Checkpoint Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle Negative Regulation Of Protein Ubiquitination Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I, TAP-dependent Signal Transduction By P53 Class Mediator Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I Positive Regulation Of Canonical Wnt Signaling Pathway Negative Regulation Of Autophagic Vacuole Assembly Regulation Of G1/S Transition Of Mitotic Cell Cycle Positive Regulation Of Protein Ubiquitination Regulation Of Cell Cycle G1/S Phase Transition Translational Termination Positive Regulation Of Proteolysis Involved In Cellular Protein Catabolic Process Negative Regulation Of Mitotic Cell Cycle Phase Transition Negative Regulation Of Canonical Wnt Signaling Pathway Positive Regulation Of Cellular Protein Catabolic Process DNA Damage Checkpoint Antigen Processing And Presentation Of Peptide Antigen Via MHC Class I Positive Regulation Of Wnt Signaling Pathway G1/S Transition Of Mitotic Cell Cycle Mitotic Cell Cycle Checkpoint Protein Polyubiquitination Translational Elongation Cellular Protein Complex Disassembly
Tagcloud ?			activates additionally along arrests clinicopathologic curbs downregulates g0 g1 great immunoprecipitation inhibits interacts mdmx nsclc oncology overexpressed phases promotes protease represent reverses shows shrna silencing tumorigenesis ubiquitin upregulation xenograft
Tagcloud (Difference) ?			activates additionally along arrests clinicopathologic curbs downregulates g0 g1 great immunoprecipitation inhibits interacts mdmx nsclc oncology overexpressed phases promotes protease represent reverses shows shrna silencing tumorigenesis ubiquitin upregulation xenograft
Tagcloud (Intersection) ?