PHLPP1 and USP1

Number of citations of the paper that reports this interaction (PMID 22426999)
4

Data Source:
BioGRID (affinity chromatography technology, affinity chromatography technology, pull down)

		PHLPP1	USP1
Gene Name		PH domain and leucine rich repeat protein phosphatase 1	ubiquitin specific peptidase 1
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Cytosol Membrane	Nucleus Nucleoplasm
	Molecular Function	Phosphoprotein Phosphatase Activity Protein Binding Metal Ion Binding	Cysteine-type Endopeptidase Activity Ubiquitin-specific Protease Activity Protein Binding
	Biological Process	Apoptotic Process Epidermal Growth Factor Receptor Signaling Pathway Fibroblast Growth Factor Receptor Signaling Pathway Entrainment Of Circadian Clock Dephosphorylation Fc-epsilon Receptor Signaling Pathway Innate Immune Response Neurotrophin TRK Receptor Signaling Pathway Phosphatidylinositol-mediated Signaling	Skeletal System Development DNA Repair Regulation Of DNA Repair Response To UV Protein Deubiquitination Monoubiquitinated Protein Deubiquitination Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Regulation Of Proteasomal Protein Catabolic Process
Pathways		Signaling by the B Cell Receptor (BCR) Signaling by FGFR in disease PIP3 activates AKT signaling Signaling by EGFRvIII in Cancer Signaling by SCF-KIT DAP12 signaling Downstream signaling events of B Cell Receptor (BCR) PI3K/AKT activation PI-3K cascade PI3K events in ERBB2 signaling Downstream signaling of activated FGFR Innate Immune System Signaling by PDGF DAP12 interactions Signalling by NGF GAB1 signalosome Signaling by Ligand-Responsive EGFR Variants in Cancer NGF signalling via TRKA from the plasma membrane Signaling by ERBB4 Signaling by Overexpressed Wild-Type EGFR in Cancer Negative regulation of the PI3K/AKT network Role of LAT2/NTAL/LAB on calcium mobilization PI3K events in ERBB4 signaling Signaling by FGFR Signaling by ERBB2 Signaling by EGFR Downstream signal transduction Fc epsilon receptor (FCERI) signaling Signaling by EGFR in Cancer PI3K/AKT Signaling in Cancer Adaptive Immune System	Fanconi Anemia pathway Regulation of the Fanconi anemia pathway
Drugs
Diseases
GWAS
Protein-Protein Interactions		4 interactors: CSNK1A1 GSK3B USP1 USP46	9 interactors: DTX3 FANCD2 PCNA PHF7 PHLPP1 TRAF6 TRIM46 UBB UBC
Entrez ID		23239	7398
HPRD ID		15145	04593
Ensembl ID		ENSG00000081913	ENSG00000162607
Uniprot IDs		O60346	O94782
PDB IDs
Enriched GO Terms of Interacting Partners?		Protein Deubiquitination Peptidyl-serine Phosphorylation Protein Modification By Small Protein Removal Positive Regulation Of Canonical Wnt Signaling Pathway Positive Regulation Of Wnt Signaling Pathway Negative Regulation Of Type B Pancreatic Cell Development Superior Temporal Gyrus Development Cellular Protein Modification Process Regulation Of Proteasomal Protein Catabolic Process Re-entry Into Mitotic Cell Cycle Negative Regulation Of Neuron Maturation Regulation Of Canonical Wnt Signaling Pathway Hypermethylation Of CpG Island Canonical Wnt Signaling Pathway Involved In Positive Regulation Of Apoptotic Process Cellular Response To Interleukin-3 Wnt Signaling Pathway Regulation Of Wnt Signaling Pathway Regulation Of Synaptic Transmission Righting Reflex Regulation Of Neuron Maturation Negative Regulation Of Glycogen (starch) Synthase Activity Cellular Protein Metabolic Process Protein Localization To Microtubule Negative Regulation Of Dendrite Morphogenesis Negative Regulation Of NFAT Protein Import Into Nucleus Monoubiquitinated Protein Deubiquitination Regulation Of Protein Catabolic Process ER Overload Response Adult Feeding Behavior Negative Regulation Of Cardiac Muscle Hypertrophy Negative Regulation Of Glycogen Biosynthetic Process Negative Regulation Of Muscle Hypertrophy Regulation Of Glycogen (starch) Synthase Activity Behavioral Response To Ethanol Regulation Of Cell Morphogenesis Positive Regulation Of Protein Export From Nucleus Regulation Of Type B Pancreatic Cell Development Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Peptidyl-threonine Phosphorylation Negative Regulation Of Dendrite Development Modification-dependent Protein Catabolic Process Protein Metabolic Process Proteolysis Involved In Cellular Protein Catabolic Process Cellular Protein Catabolic Process Regulation Of DNA Methylation Myoblast Fusion Reflex Protein Localization To Cytoskeleton Protein Catabolic Process Regulation Of Proteolysis	Nucleotide-binding Oligomerization Domain Containing Signaling Pathway Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Neurotrophin TRK Receptor Signaling Pathway Neurotrophin Signaling Pathway Fc-epsilon Receptor Signaling Pathway Toll-like Receptor 5 Signaling Pathway Toll-like Receptor 10 Signaling Pathway I-kappaB Kinase/NF-kappaB Signaling Toll-like Receptor TLR6:TLR2 Signaling Pathway Toll-like Receptor TLR1:TLR2 Signaling Pathway Toll-like Receptor 2 Signaling Pathway Toll-like Receptor 9 Signaling Pathway Fc Receptor Signaling Pathway TRIF-dependent Toll-like Receptor Signaling Pathway MyD88-independent Toll-like Receptor Signaling Pathway Toll-like Receptor 3 Signaling Pathway MyD88-dependent Toll-like Receptor Signaling Pathway Toll-like Receptor 4 Signaling Pathway JNK Cascade Immune Response-regulating Cell Surface Receptor Signaling Pathway Toll-like Receptor Signaling Pathway T Cell Receptor Signaling Pathway Viral Protein Processing Stress-activated MAPK Cascade Stress-activated Protein Kinase Signaling Cascade Positive Regulation Of NF-kappaB Transcription Factor Activity Immune Response-regulating Signaling Pathway Pattern Recognition Receptor Signaling Pathway Innate Immune Response-activating Signal Transduction Positive Regulation Of Protein Ubiquitination Antigen Receptor-mediated Signaling Pathway Notch Signaling Pathway Activation Of MAPK Activity Activation Of Innate Immune Response G1/S Transition Of Mitotic Cell Cycle Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Fibroblast Growth Factor Receptor Signaling Pathway Protein Ubiquitination Cellular Response To Growth Factor Stimulus Protein Polyubiquitination DNA Repair Response To Growth Factor Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Protein Modification By Small Protein Conjugation Positive Regulation Of Innate Immune Response Cellular Response To Fibroblast Growth Factor Stimulus Notch Receptor Processing Response To Fibroblast Growth Factor Virion Assembly
Tagcloud ?		alphat alphatp angiogenesis biochem dissociation hek293 heterodimer htap htap1 inactive inc lipid location mediator overexpressed periodicals phosphatidylinositol pi3kgamma pkb reactivated sec14l2 sensor stimulates tocopherol tocopheryl translate vasculogenesis vegf wiley	bomb coimmunoprecipitation collated cytoskeleton defines depicts dissect evolutionarily fate fih hif1an interacted interesting mib mib2 mind notch protease ran screens summarized trabid traf ubiquitin ubiquitylate ubiquitylation usp9 zebrafish zranb1
Tagcloud (Difference) ?		alphat alphatp angiogenesis biochem dissociation hek293 heterodimer htap htap1 inactive inc lipid location mediator overexpressed periodicals phosphatidylinositol pi3kgamma pkb reactivated sec14l2 sensor stimulates tocopherol tocopheryl translate vasculogenesis vegf wiley	bomb coimmunoprecipitation collated cytoskeleton defines depicts dissect evolutionarily fate fih hif1an interacted interesting mib mib2 mind notch protease ran screens summarized trabid traf ubiquitin ubiquitylate ubiquitylation usp9 zebrafish zranb1
Tagcloud (Intersection) ?