SYNE2 and GLE1

		SYNE2	GLE1
Description		spectrin repeat containing nuclear envelope protein 2	GLE1 RNA export mediator
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GO Annotations	Cellular Component	Fibrillar Center Nucleus Nuclear Envelope Nuclear Outer Membrane Nucleoplasm Nucleolus Cytoplasm Mitochondrion Cytoskeleton Plasma Membrane Focal Adhesion Cilium Membrane Sarcoplasmic Reticulum Myofibril Z Disc Lamellipodium Membrane Filopodium Membrane Nuclear Membrane Nuclear Lumen Sarcoplasmic Reticulum Membrane Meiotic Nuclear Membrane Microtubule Tethering Complex Intermediate Filament Cytoskeleton Extracellular Exosome Anchoring Junction	Extracellular Space Nucleus Nuclear Envelope Nuclear Pore Nucleolus Cytoplasm Centrosome Centriole Cytosol Membrane Nuclear Membrane Ciliary Basal Body Nuclear Pore Cytoplasmic Filaments
	Molecular Function	Actin Binding Protein Binding Cytoskeleton-nuclear Membrane Anchor Activity	Inositol Hexakisphosphate Binding Protein Binding Phospholipid Binding Translation Initiation Factor Binding Identical Protein Binding
	Biological Process	Nuclear Migration Nucleokinesis Involved In Cell Motility In Cerebral Cortex Radial Glia Guided Migration Positive Regulation Of Cell Migration Nuclear Migration Along Microfilament Centrosome Localization Regulation Of Cilium Assembly	MRNA Export From Nucleus Nucleocytoplasmic Transport Protein Transport Poly(A)+ MRNA Export From Nucleus MRNA Transport
Pathways		Meiotic synapsis	Transport of Mature mRNA derived from an Intron-Containing Transcript
Drugs
Diseases		Emery-Dreifuss muscular dystrophy	Lethal arthrogryposis with anterior horn cell disease Lethal congenital contractural syndrome (LCCS)
GWAS		Anorexia nervosa, attention-deficit/hyperactivity disorder, autism spectrum disorder, bipolar disorder, major depression, obsessive-compulsive disorder, schizophrenia, or Tourette syndrome (pleiotropy) ( 31835028) Atrial fibrillation ( 22544366 28416818 29892015 30061737) Blond vs. brown/black hair color ( 30531825) Cutaneous malignant melanoma ( 32341527) Cutaneous melanoma or hair colour ( 32341527) Depression ( 29700475) HDL cholesterol levels ( 32109663) Metabolite levels ( 23823483) Nevus count or cutaneous melanoma ( 30429480 32341527) PR interval ( 32439900) Psoriasis ( 25854761) Pulmonary function decline ( 22424883) Serum metabolite concentrations in chronic kidney disease ( 29545352) Serum metabolite levels ( 33031748) Serum metabolite ratios in chronic kidney disease ( 29545352) Sphingomyelin levels ( 31551469) Youthful appearance (self-reported) ( 32339537)	Axial length ( 24144296) Body mass index ( 26426971)
Interacting Genes		12 interacting genes: ABI1 ACTC1 BRAP CALM1 CTNNB1 MAPK3 MAPK8IP2 MEOX2 MTNR1B PML RNF10 SASH1	4 interacting genes: KRT10 NUP155 NUP42 UXT
Entrez ID		23224	2733
HPRD ID		09763	04536
Ensembl ID		ENSG00000054654	ENSG00000119392
Uniprot IDs		Q8WXH0	A0A804HJ70 B3KMG0 Q53GS7
PDB IDs		4DXS 4FI9 6XF1	6B4F 6B4I 6B4J
Enriched GO Terms of Interacting Partners?		Trachea Formation Positive Regulation Of Cell Communication Intracellular Signaling Cassette Intracellular Signal Transduction MAPK Cascade Positive Regulation Of Telomere Maintenance Signal Transduction Regulation Of Intracellular Signal Transduction Positive Regulation Of Chromosome Organization Regulation Of Telomere Maintenance Nuclear Receptor-mediated Signaling Pathway Animal Organ Formation Regulation Of Nervous System Process Nuclear Steroid Receptor Activity Positive Regulation Of Signal Transduction Protein Modification By Small Protein Conjugation Positive Regulation Of Intracellular Signal Transduction Hormone-mediated Signaling Pathway Regulation Of Signal Transduction Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of Signaling Regulation Of Stress-activated MAPK Cascade Anatomical Structure Formation Involved In Morphogenesis Lamellipodium Protein Kinase Binding Post-translational Protein Modification Positive Regulation Of MAPK Cascade Regulation Of Stress-activated Protein Kinase Signaling Cascade Positive Regulation Of Metabolic Process Anatomical Structure Morphogenesis Regulation Of Cell Communication Regulation Of Calcium Ion Transport Regulation Of Signaling Regulation Of Telomere Maintenance Via Telomerase Thymus Development Glial Cell Fate Determination SMAD Binding Negative Regulation Of Gliogenesis Phosphatase Binding Regulation Of Myelination Canonical Wnt Signaling Pathway Involved In Mesenchymal Stem Cell Differentiation Regulation Of Telomere Maintenance Via Telomere Lengthening Limb Development Nuclear Receptor Activity Intracellular Receptor Signaling Pathway Negative Regulation Of Translation In Response To Oxidative Stress Dendrite Morphogenesis Sarcomere Glutamatergic Synapse Regulation Of System Process	Intracellular Transport Cellular Localization Establishment Of Localization In Cell Nuclear Envelope Nuclear Membrane Centrosome Cycle Microtubule Organizing Center Organization Organelle Transport Along Microtubule Nuclear Pore Protein Tetramerization Cytoskeleton Nuclear Pore Inner Ring Protein Localization To Nuclear Inner Membrane RNA Transport MRNA Transport Nuclear Export Nuclear Migration Along Microfilament Nucleokinesis Involved In Cell Motility In Cerebral Cortex Radial Glia Guided Migration Spindle Pole Positive Regulation Of Protein Glycosylation Transport Along Microtubule Nuclear Migration Along Microtubule Cytoskeleton-nuclear Membrane Anchor Activity Microtubule-based Process Cytoskeleton-dependent Intracellular Transport Golgi Disassembly Nucleobase-containing Compound Transport Regulation Of Protein Glycosylation Microtubule-based Transport Transcription-dependent Tethering Of RNA Polymerase II Gene DNA At Nuclear Periphery Cytoskeleton Organization Golgi Ribbon Formation Microtubule Binding Protein Complex Oligomerization Importin-alpha Family Protein Binding Establishment Of Organelle Localization Nuclear Transport Nucleocytoplasmic Transport Atrial Cardiac Muscle Cell Action Potential Meiotic Nuclear Membrane Microtubule Tethering Complex Golgi Cis Cisterna RPAP3/R2TP/prefoldin-like Complex Nuclear Export Signal Receptor Activity Protein Transport Asymmetric Cell Division Protein Localization To Nuclear Envelope Meiotic Spindle Assembly Protein Heterotetramerization Organelle Organization Positive Regulation Of Glycoprotein Biosynthetic Process
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