FLOT2 and DXO

Number of citations of the paper that reports this interaction (PMID 14667819)
24

Data Source:
HPRD (two hybrid)

		FLOT2	DXO
Gene Name		flotillin 2	decapping exoribonuclease
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Acrosomal Membrane Endosome Plasma Membrane Caveola Focal Adhesion Membrane Flotillin Complex Endocytic Vesicle Vesicle Perinuclear Region Of Cytoplasm Extracellular Vesicular Exosome	Nucleoplasm Cytoplasm Plasma Membrane
	Molecular Function	Protease Binding Protein Binding Ionotropic Glutamate Receptor Binding	Nucleotide Binding Magnesium Ion Binding MRNA Binding 5'-3' Exonuclease Activity RNA Pyrophosphohydrolase Activity
	Biological Process	Cell Adhesion Epidermis Development Negative Regulation Of Gene Expression Protein Stabilization Establishment Of Protein Localization To Plasma Membrane Negative Regulation Of Amyloid Precursor Protein Catabolic Process	MRNA Catabolic Process Metabolic Process RNA Destabilization Nuclear MRNA Surveillance Nucleic Acid Phosphodiester Bond Hydrolysis
Pathways
Drugs
Diseases
GWAS
Protein-Protein Interactions		8 interactors: APP CAV1 CAV2 DXO FLOT1 FYN NMNAT1 SPATA24	8 interactors: EXOSC10 EXOSC4 EXOSC7 FLOT2 PRMT6 UPF1 XRN1 XRN2
Entrez ID		2319	1797
HPRD ID		00580	16186
Ensembl ID		ENSG00000132589	ENSG00000204348
Uniprot IDs		J3QLD9 Q14254 Q6FG43 Q9BTI6	O77932
PDB IDs
Enriched GO Terms of Interacting Partners?		Caveola Assembly Membrane Raft Assembly Membrane Raft Organization Membrane Assembly Membrane Biogenesis Plasma Membrane Organization Negative Regulation Of Endothelial Cell Proliferation Regulation Of Protein Tyrosine Kinase Activity Cell Differentiation T Cell Costimulation Blood Coagulation Hemostasis Endomembrane System Organization Regulation Of Endothelial Cell Proliferation Regulation Of Membrane Repolarization During Action Potential Negative Regulation Of Peptidyl-tyrosine Autophosphorylation Water-soluble Vitamin Metabolic Process Feeding Behavior Vascular Endothelial Growth Factor Receptor Signaling Pathway Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Axonogenesis Vitamin Metabolic Process Synaptic Growth At Neuromuscular Junction Nitric Oxide Homeostasis Axon Development Cell Morphogenesis Involved In Neuron Differentiation Regulation Of Body Fluid Levels Vesicle-mediated Transport Negative Regulation Of Epithelial Cell Proliferation Wound Healing Dendrite Development Regulation Of Signal Transduction Skeletal Muscle Tissue Development Learning Neuron Projection Morphogenesis Receptor Internalization Involved In Canonical Wnt Signaling Pathway Regulation Of Cardiac Muscle Cell Action Potential Involved In Regulation Of Contraction Positive Regulation Of Dopamine Receptor Signaling Pathway Collateral Sprouting In Absence Of Injury Regulation Of Inward Rectifier Potassium Channel Activity Positive Regulation Of Peptidase Activity Regulation Of Protein Binding Skeletal Muscle Organ Development Endocytosis Protein Localization To Plasma Membrane Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Multicellular Organismal Development Response To Wounding Negative Regulation Of Tyrosine Phosphorylation Of Stat5 Protein Negative Regulation Of Pinocytosis	Histone MRNA Catabolic Process RNA Catabolic Process Histone MRNA Metabolic Process RNA Phosphodiester Bond Hydrolysis, Exonucleolytic Nuclear-transcribed MRNA Catabolic Process Nuclear MRNA Surveillance MRNA Catabolic Process Aromatic Compound Catabolic Process RNA Surveillance MRNA Metabolic Process Nucleic Acid Phosphodiester Bond Hydrolysis RNA Phosphodiester Bond Hydrolysis Exonucleolytic Nuclear-transcribed MRNA Catabolic Process Involved In Deadenylation-dependent Decay Cellular Macromolecule Catabolic Process Nuclear-transcribed MRNA Catabolic Process, Exonucleolytic RRNA Metabolic Process Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay Dosage Compensation By Inactivation Of X Chromosome Catabolic Process Dosage Compensation RRNA Catabolic Process RNA Metabolic Process RRNA Processing Gene Expression NcRNA Metabolic Process Maturation Of 5.8S RRNA Ribosome Biogenesis Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Ribonucleoprotein Complex Biogenesis Nitrogen Compound Metabolic Process DNA Metabolic Process Nuclear Retention Of Unspliced Pre-mRNA At The Site Of Transcription Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay Histone H3-R2 Methylation RNA Localization Nuclear Polyadenylation-dependent RRNA Catabolic Process CUT Catabolic Process Regulation Of Gene Expression, Epigenetic DNA Deamination Intracellular MRNA Localization Peptidyl-arginine Methylation, To Asymmetrical-dimethyl Arginine Regulation Of Translational Termination Histone H4-R3 Methylation Negative Regulation Of Amyloid Precursor Protein Catabolic Process Peptidyl-arginine N-methylation Histone Arginine Methylation Peptidyl-arginine Methylation
Tagcloud ?		adjacent aimed archived biomarker biopsies blotting breast classification clinicopathological duration embedded erbb2 flotillin histological ihc immunohistochemistry implicated multivariate noncancerous paired paraffin prognostic quantified real shorter significance statistical tissues upregulated	1beta bioreactor cd11b cdh5 constructs dataset dioxepan ec ecs engineered hif immunodeficient immunofluorescent implanted lactide leukocyte leukocytes lla migrating msc mscs multipotent pecam retrieved scaffolds subcutaneously toll transmigration umbilical
Tagcloud (Difference) ?		adjacent aimed archived biomarker biopsies blotting breast classification clinicopathological duration embedded erbb2 flotillin histological ihc immunohistochemistry implicated multivariate noncancerous paired paraffin prognostic quantified real shorter significance statistical tissues upregulated	1beta bioreactor cd11b cdh5 constructs dataset dioxepan ec ecs engineered hif immunodeficient immunofluorescent implanted lactide leukocyte leukocytes lla migrating msc mscs multipotent pecam retrieved scaffolds subcutaneously toll transmigration umbilical
Tagcloud (Intersection) ?