FLOT2

Description		flotillin 2
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GO Annotations	Cellular Component	Uropod Acrosomal Membrane Endosome Plasma Membrane Caveola Adherens Junction Focal Adhesion Membrane Basolateral Plasma Membrane Apical Plasma Membrane Flotillin Complex Lamellipodium Endocytic Vesicle Cortical Actin Cytoskeleton Cytoplasmic Vesicle Vesicle Dendrite Cytoplasm Cell-cell Contact Zone Membrane Raft Perinuclear Region Of Cytoplasm Extracellular Exosome Glutamatergic Synapse
	Molecular Function	Protease Binding Protein Binding
	Biological Process	Cell Adhesion Epidermis Development Negative Regulation Of Gene Expression Positive Regulation Of Cell-cell Adhesion Positive Regulation Of Canonical NF-kappaB Signal Transduction Protein Localization To Plasma Membrane Raft Regulation Of Myoblast Differentiation Protein Stabilization Protein Localization To Plasma Membrane Anterograde Dendritic Transport Regulation Of Postsynaptic Membrane Neurotransmitter Receptor Levels Negative Regulation Of Amyloid Precursor Protein Catabolic Process Positive Regulation Of Establishment Of T Cell Polarity
Pathways		RIPK1-mediated regulated necrosis Regulation of necroptotic cell death Synaptic adhesion-like molecules RHOA GTPase cycle RHOB GTPase cycle RHOC GTPase cycle RND3 GTPase cycle RND1 GTPase cycle
Drugs
Diseases
GWAS		Declining hemoglobin trajectory in blood donors ( 33491795) Mean corpuscular hemoglobin ( 29403010) Red blood cell count ( 27863252)
Interacting Genes		12 interacting genes: ANXA1 APP CAV1 CAV2 DXO FLOT1 FYN HGS MAGEB4 NMNAT1 SPATA24 UBC
Entrez ID		2319
HPRD ID		00580
Ensembl ID		ENSG00000132589
Uniprot IDs		J3QLD9 Q14254 Q6FG43 Q9BTI6
PDB IDs		9BQ2
Enriched GO Terms of Interacting Partners?		Caveola Assembly Plasma Membrane Raft Assembly Membrane Raft Assembly Plasma Membrane Raft Organization Membrane Raft Caveolar Macromolecular Signaling Complex Membrane Raft Organization Growth Factor Receptor Binding Endosome Early Endosome Membrane Endocytosis Membrane Assembly Peptidase Activator Activity Caveola Regulation Of Vesicle-mediated Transport Extracellular Matrix Organization Extracellular Structure Organization Receptor-mediated Endocytosis Of Virus By Host Cell Cellular Response To Growth Factor Stimulus Regulation Of Dendritic Spine Maintenance Import Into Cell Endocytosis Involved In Viral Entry Into Host Cell Response To Growth Factor Early Endosome Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Cell-cell Adhesion Regulation Of Neurotransmitter Uptake Regulation Of Protein Catabolic Process Negative Regulation Of Receptor Signaling Pathway Via JAK-STAT Signaling Receptor Binding Positive Regulation Of Cell Activation G Protein-coupled Receptor Signaling Pathway Regulation Of Calcium Ion Transmembrane Transport Acrosomal Membrane Focal Adhesion Positive Regulation Of Transport Cytoplasmic Vesicle Regulation Of Extrinsic Apoptotic Signaling Pathway Ephrin Receptor Binding Negative Regulation Of Receptor Signaling Pathway Via STAT Receptor-mediated Endocytosis Basement Membrane Organization Negative Regulation Of Macromolecule Biosynthetic Process Plasma Membrane Raft Regulation Of Intrinsic Apoptotic Signaling Pathway Negative Regulation Of Developmental Process Positive Regulation Of Cell Adhesion Negative Regulation Of Biosynthetic Process Endothelial Cell Proliferation Regulation Of Cell-cell Adhesion
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