STAB1 and TWF2

		STAB1	TWF2
Description		stabilin 1	twinfilin actin binding protein 2
Image		No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Membrane Endocytic Vesicle Membrane	Cytoplasm Cytoskeleton Actin Filament Myofibril Lamellipodium Filopodium Growth Cone Stereocilium Cell Projection Perinuclear Region Of Cytoplasm Extracellular Exosome
	Molecular Function	Low-density Lipoprotein Particle Receptor Activity Scavenger Receptor Activity Calcium Ion Binding Protein Binding Hyaluronic Acid Binding Protein-disulfide Reductase Activity Low-density Lipoprotein Particle Binding	RNA Binding Actin Binding Actin Monomer Binding Protein Kinase C Binding Protein Binding ATP Binding Phosphatidylinositol-4,5-bisphosphate Binding Anion Binding Cadherin Binding Actin Filament Binding
	Biological Process	Endocytosis Receptor-mediated Endocytosis Inflammatory Response Cell Adhesion Cell-cell Signaling Negative Regulation Of Angiogenesis Defense Response To Bacterium	Regulation Of Lamellipodium Assembly Positive Regulation Of Lamellipodium Assembly Positive Regulation Of Neuron Projection Development Cell Projection Organization Actin Filament Depolymerization Negative Regulation Of Actin Filament Polymerization Regulation Of Microvillus Length Regulation Of Actin Cytoskeleton Organization Positive Regulation Of Axon Extension Barbed-end Actin Filament Capping Cellular Response To Retinoic Acid Cellular Response To Growth Factor Stimulus
Pathways		Scavenging by Class H Receptors	Sensory processing of sound by inner hair cells of the cochlea Sensory processing of sound by outer hair cells of the cochlea
Drugs
Diseases
GWAS		A body shape index ( 34021172) Adiponectin levels ( 31178129) Apolipoprotein A1 levels ( 32203549) Autism spectrum disorder or schizophrenia ( 28540026) Bipolar disorder ( 21926972 31043756) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cognitive function ( 25644384) Colon cancer ( 33632709) Cortical surface area (MOSTest) ( 32665545) Distal colorectal cancer ( 33632709) Diverticular disease ( 30177863) HDL cholesterol ( 24097068) HDL cholesterol levels ( 28334899) Height ( 31562340) Hematocrit ( 27863252) Hodgkin's lymphoma ( 34216518) Intelligence (MTAG) ( 29326435) Iron status biomarkers (ferritin levels) ( 33536631) Parkinson's disease ( 28892059) Schizophrenia ( 29483656 25056061 23974872) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545) Urinary albumin-to-creatinine ratio ( 31511532) Waist circumference adjusted for body mass index ( 34021172) Waist-hip index ( 34021172) Waist-hip ratio ( 20935629) Waist-to-hip ratio adjusted for BMI ( 34021172) Waist-to-hip ratio adjusted for BMI (additive genetic model) ( 30778226)	Autism spectrum disorder or schizophrenia ( 28540026) Bipolar disorder ( 21926972) Schizophrenia ( 23974872)
Interacting Genes		8 interacting genes: CHID1 DYRK1A GGA1 GGA2 GGA3 NUFIP2 ORC5 PIK3R2	7 interacting genes: ARHGDIA CEBPA CHGB FOXJ1 ILK POT1 TERF2IP
Entrez ID		23166	11344
HPRD ID		09778	08464
Ensembl ID		ENSG00000010327	ENSG00000247596
Uniprot IDs		Q9NY15	Q6IBS0
PDB IDs			2VAC 2W0I
Enriched GO Terms of Interacting Partners?		Golgi To Plasma Membrane Protein Transport Protein Localization To Cell Surface Establishment Of Protein Localization To Membrane Establishment Of Protein Localization To Plasma Membrane Trans-Golgi Network Golgi To Plasma Membrane Transport Ubiquitin Binding Post-Golgi Vesicle-mediated Transport Phosphatidylinositol Binding Vesicle-mediated Transport To The Plasma Membrane Localization Within Membrane Intracellular Protein Transport Protein Localization To Plasma Membrane Early Endosome Membrane Regulation Of Amyloid-beta Formation Protein Transport Protein Localization To Cell Periphery Regulation Of Amyloid Precursor Protein Catabolic Process Histone H3T45 Kinase Activity Establishment Of Protein Localization Endosome Membrane Small GTPase Binding Golgi Vesicle Transport Protein Localization To Membrane Regulation Of Amide Metabolic Process Actin Filament Ribonucleoprotein Complex Regulation Of Supramolecular Fiber Organization Endoplasmic Reticulum Signal Peptide Binding Regulation Of Protein-containing Complex Assembly Negative Regulation Of Heterochromatin Formation Negative Regulation Of Protein-containing Complex Assembly Regulation Of Neurofibrillary Tangle Assembly Splicing Factor Binding Origin Recognition Complex Regulation Of Actin Filament Polymerization Regulation Of Actin Polymerization Or Depolymerization Intracellular Protein Localization Regulation Of Actin Filament Length 1-phosphatidylinositol-3-kinase Regulator Activity Signal Recognition Particle SRP-dependent Cotranslational Protein Targeting To Membrane, Signal Sequence Recognition Box C/D Methylation Guide SnoRNP Complex Regulation Of Microvillus Length Anion Binding Positive Regulation Of Lysosomal Protein Catabolic Process Regulation Of Cytoskeleton Organization Negative Regulation Of Cytoskeleton Organization Negative Regulation Of Supramolecular Fiber Organization 7S RNA Binding	Nuclear Telomere Cap Complex Shelterin Complex G-rich Strand Telomeric DNA Binding Telomere Capping Telomere Maintenance Via Telomerase RNA-templated DNA Biosynthetic Process Telomeric DNA Binding Telomere Maintenance Via Telomere Lengthening Intracellular Signal Transduction RNA Polymerase I Transcription Regulatory Region Sequence-specific DNA Binding Glomerular Parietal Epithelial Cell Development Establishment Or Maintenance Of Apical/basal Cell Polarity Positive Regulation Of Central B Cell Tolerance Induction Vasoconstriction Of Artery Involved In Ischemic Response To Lowering Of Systemic Arterial Blood Pressure Negative Regulation Of Telomere Maintenance Positive Regulation Of DNA Strand Elongation Positive Regulation Of Telomeric D-loop Disassembly G-rich Single-stranded DNA Binding Positive Regulation Of Osteoblast Differentiation Response To Vitamin B2 C/EBP Complex Central Tolerance Induction Positive Regulation Of Lung Ciliated Cell Differentiation Positive Regulation Of B Cell Tolerance Induction Negative Regulation Of Germinal Center Formation Positive Regulation Of Telomeric Loop Disassembly Positive Regulation Of Telomere Maintenance Negative Regulation Of Chromosome Organization Negative Regulation Of DNA Recombination At Telomere Rho GDP-dissociation Inhibitor Activity CHOP-C/EBP Complex Protein Localization To Cell Cortex DNA Biosynthetic Process 8-hydroxy-2'-deoxyguanosine DNA Binding Telomeric G-quadruplex DNA Binding Intracellular Signaling Cassette Regulation Of Non-canonical NF-kappaB Signal Transduction Telomere Maintenance Positive Regulation Of Chromosome Organization White Fat Cell Proliferation Metanephric Part Of Ureteric Bud Development Regulation Of Telomere Maintenance Telomeric D-loop Binding Telomere Assembly Negative Regulation Of Hemopoiesis Negative Regulation Of Hematopoietic Stem Cell Proliferation Rb-E2F Complex Ciliary Basal Body Organization Single-stranded Telomeric DNA Binding Telomere Organization
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