PYCR2 and UBE4B

Number of citations of the paper that reports this interaction (PubMedID 35669517)
41

Data Source:
BioGRID (affinity chromatography technology, enzymatic study)

		PYCR2	UBE4B
Description		pyrroline-5-carboxylate reductase 2	ubiquitination factor E4B
Image
GO Annotations	Cellular Component	Cytoplasm Mitochondrion Mitochondrial Matrix Cytosol	Ubiquitin Ligase Complex Nucleus Cytoplasm
	Molecular Function	Pyrroline-5-carboxylate Reductase Activity Protein Binding Oxidoreductase Activity	Ubiquitin-protein Transferase Activity Protein Binding ATP Binding Transferase Activity Enzyme Binding Ubiquitin-ubiquitin Ligase Activity Ubiquitin Protein Ligase Activity
	Biological Process	Amino Acid Biosynthetic Process Cellular Response To Oxidative Stress L-proline Biosynthetic Process	Protein Polyubiquitination Ventricular Trabecula Myocardium Morphogenesis Ubiquitin-dependent Protein Catabolic Process Protein Monoubiquitination Granzyme-mediated Apoptotic Signaling Pathway Response To UV Protein Ubiquitination Protein Catabolic Process Neuron Projection Development Response To Endoplasmic Reticulum Stress ERAD Pathway Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Protein Autoubiquitination
Pathways		Glutamate and glutamine metabolism
Drugs		NADH Proline
Diseases
GWAS			Atrial fibrillation ( 29892015) Femur bone mineral density x serum urate levels interaction ( 34046847) Hemoglobin levels ( 33491795) Hepatocellular carcinoma ( 20676096) Hip circumference adjusted for BMI ( 34021172) Resting heart rate ( 27798624)
Interacting Genes		6 interacting genes: APP CIC FXR1 FXR2 SKIL UBE4B	27 interacting genes: ATXN3 CASP3 CASP6 CASP7 CDKN2A CNTN2 DNAJC7 ESR1 FEZ1 GZMB HGS HRAS MAPK3 OTUB1 PGAM5 PPP3CA PRMT1 PYCR2 RAD23A RIPK4 TP53 TRA2A TRIP12 UBE2D2 UBE2D3 VAV2 VCP
Entrez ID		29920	10277
HPRD ID		17939	11659
Ensembl ID		ENSG00000143811	ENSG00000130939
Uniprot IDs		A0A087WTV6 A0A0S2Z5U6 Q96C36	O95155
PDB IDs		6LHM	2KRE 3L1X 3L1Z 5O75
Enriched GO Terms of Interacting Partners?		Regulation Of Long-term Neuronal Synaptic Plasticity Regulation Of Translation At Presynapse, Modulating Synaptic Transmission Regulation Of Neuronal Synaptic Plasticity Positive Regulation Of Long-term Neuronal Synaptic Plasticity Negative Regulation Of Long-term Synaptic Potentiation Translation Regulator Activity Regulation Of Synaptic Plasticity Dentate Gyrus Development Presynapse Postsynapse Positive Regulation Of Neurogenesis Positive Regulation Of Nervous System Development Presynaptic Modulation Of Chemical Synaptic Transmission Regulation Of Long-term Synaptic Potentiation Positive Regulation Of Cell Differentiation Neuron Projection Protein Heterodimerization Activity Positive Regulation Of Extrinsic Apoptotic Signaling Pathway Negative Regulation Of Macromolecule Biosynthetic Process Regulation Of Neurogenesis Negative Regulation Of Biosynthetic Process Amyloid-beta Complex Growth Cone Lamellipodium Regulation Of Translation Regulation Of Response To Calcium Ion Amylin Binding Positive Regulation Of Toll Signaling Pathway Positive Regulation Of Cell Development Regulation Of Nervous System Development Cytoplasmic Ribonucleoprotein Granule Granzyme-mediated Apoptotic Signaling Pathway Negative Regulation Of Macromolecule Metabolic Process Chromatin Binding Modulation Of Chemical Synaptic Transmission Cytoplasmic Stress Granule Positive Regulation Of Developmental Process MRNA Destabilization RNA Destabilization Negative Regulation Of Metabolic Process Negative Regulation Of RNA Metabolic Process Acetylcholine Receptor Activator Activity Positive Regulation Of Catabolic Process Lipoprotein Particle Developmental Process Positive Regulation Of Protein Import Positive Regulation Of MRNA Catabolic Process Memory Negative Regulation Of Nucleobase-containing Compound Metabolic Process Post-transcriptional Regulation Of Gene Expression MRNA Transport	Catabolic Process Cytosol Cellular Response To Staurosporine Proteolysis DNA Damage Response Protein Metabolic Process Macromolecule Catabolic Process Protein Catabolic Process Protein Modification Process Nucleoplasm Response To Stress Pyroptotic Inflammatory Response Positive Regulation Of Intracellular Signal Transduction Proteolysis Involved In Protein Catabolic Process Negative Regulation Of Metabolic Process Programmed Cell Death DNA Repair Cell Death Intracellular Signal Transduction Regulation Of Protein Metabolic Process Cysteine-type Peptidase Activity Regulation Of Proteolysis Ubiquitin-dependent Protein Catabolic Process Cellular Response To Stress Macromolecule Metabolic Process Regulation Of Metabolic Process Modification-dependent Protein Catabolic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Signal Transduction Regulation Of Primary Metabolic Process TORC1 Signaling Negative Regulation Of TORC1 Signaling Post-translational Protein Modification Positive Regulation Of Neuron Apoptotic Process Nucleic Acid Metabolic Process Macroautophagy Apoptotic Process Autophagy Regulation Of Ubiquitin-dependent Protein Catabolic Process Proteasomal Protein Catabolic Process Positive Regulation Of Cell Communication Positive Regulation Of Signaling TOR Signaling Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of TOR Signaling DNA Metabolic Process Regulation Of Signal Transduction Regulation Of Cellular Response To Stress Regulation Of TORC1 Signaling Regulation Of Macromolecule Metabolic Process
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?