CEP135

Description		centrosomal protein 135
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GO Annotations	Cellular Component	Cytoplasm Centrosome Centriole Cytosol Cytoskeleton
	Molecular Function	Protein Binding Microtubule Binding Tubulin Binding Identical Protein Binding Protein Homodimerization Activity
	Biological Process	Centriole Replication Centriole-centriole Cohesion Positive Regulation Of Non-motile Cilium Assembly Positive Regulation Of Establishment Of Protein Localization
Pathways		Regulation of PLK1 Activity at G2/M Transition Loss of Nlp from mitotic centrosomes Recruitment of mitotic centrosome proteins and complexes Loss of proteins required for interphase microtubule organization from the centrosome Recruitment of NuMA to mitotic centrosomes Anchoring of the basal body to the plasma membrane AURKA Activation by TPX2
Drugs
Diseases
GWAS		Bone mineral density (hip) ( 30172743) Daytime sleep phenotypes ( 27126917) Femoral neck bone mineral density ( 30172743) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)
Novel Interacting Genes		5 novel interacting genes: CLOCK DCUN1D4 REST SPINK2 USP46
Interacting Genes		2 interacting genes: PIBF1 SMAD9
Entrez ID		9662
HPRD ID		11097
Ensembl ID		ENSG00000174799
Uniprot IDs		Q66GS9
PDB IDs		5FCN 5NG4
Enriched GO Terms of Interacting Partners?		DNA-binding Transcription Factor Activity Transcription Regulator Complex Stem Cell Differentiation Positive Regulation Of Macromolecule Metabolic Process Heteromeric SMAD Protein Complex SMAD Protein Complex Regulation Of Glucocorticoid Biosynthetic Process Regulation Of Insulin Secretion Negative Regulation Of Dense Core Granule Biogenesis Negative Regulation Of Mesenchymal Stem Cell Differentiation Negative Regulation Of Small Molecule Metabolic Process Negative Regulation Of Amniotic Stem Cell Differentiation Regulation Of Peptide Hormone Secretion Negative Regulation Of Aldosterone Biosynthetic Process Negative Regulation Of Glucocorticoid Biosynthetic Process Negative Regulation Of Lipid Biosynthetic Process Negative Regulation Of Calcium Ion-dependent Exocytosis Regulation Of Cortisol Biosynthetic Process Regulation Of Ketone Metabolic Process Negative Regulation Of Lipid Metabolic Process Negative Regulation Of Cortisol Biosynthetic Process Regulation Of Aldosterone Biosynthetic Process Regulation Of Lipid Biosynthetic Process Negative Regulation Of Steroid Hormone Biosynthetic Process Regulation Of Mesenchymal Stem Cell Differentiation Protein Modification Process CLOCK-BMAL Transcription Complex Negative Regulation Of Nuclear Receptor-mediated Glucocorticoid Signaling Pathway Regulation Of Type B Pancreatic Cell Development Negative Regulation Of Natural Killer Cell Activation Negative Regulation Of Tyrosine Phosphorylation Of STAT Protein Interleukin-4 Receptor Binding Negative Regulation Of Prostaglandin Biosynthetic Process Activation Of Janus Kinase Activity Ubiquitin-like Protein Binding Positive Regulation Of Protein Neddylation Adult Feeding Behavior Righting Reflex Behavioral Response To Ethanol Positive Regulation Of Metabolic Process Regulation Of Hormone Secretion Cellular Response To Electrical Stimulus Regulation Of Protein Secretion Regulation Of Glucocorticoid Metabolic Process Detection Of Mechanical Stimulus Involved In Sensory Perception Of Sound Cardiac Muscle Cell Myoblast Differentiation Regulation Of Prostaglandin Biosynthetic Process Host-mediated Suppression Of Viral Transcription Cardioblast Differentiation Chromatoid Body
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