CEP135 and PIBF1

Number of citations of the paper that reports this interaction (PubMedID 27107012)
72

Data Source:
BioGRID (proximity labelling technology, affinity chromatography technology, two hybrid, proximity labelling technology)

		CEP135	PIBF1
Description		centrosomal protein 135	progesterone immunomodulatory binding factor 1
Image			No pdb structure
GO Annotations	Cellular Component	Cytoplasm Centrosome Centriole Cytosol Cytoskeleton	Extracellular Region Extracellular Space Nucleus Cytoplasm Centrosome Microtubule Organizing Center Cytoskeleton Centriolar Satellite Ciliary Basal Body
	Molecular Function	Protein Binding Microtubule Binding Tubulin Binding Identical Protein Binding Protein Homodimerization Activity	Interleukin-4 Receptor Binding Protein Binding
	Biological Process	Centriole Replication Centriole-centriole Cohesion Positive Regulation Of Non-motile Cilium Assembly Positive Regulation Of Establishment Of Protein Localization	Immune System Process Mitotic Metaphase Chromosome Alignment Negative Regulation Of Prostaglandin Biosynthetic Process Negative Regulation Of Interleukin-12 Production Positive Regulation Of Interleukin-10 Production Negative Regulation Of Natural Killer Cell Activation Positive Regulation Of Tyrosine Phosphorylation Of STAT Protein Negative Regulation Of Tyrosine Phosphorylation Of STAT Protein Activation Of Janus Kinase Activity Cilium Assembly Protein Localization To Centrosome Mitotic Spindle Assembly Non-motile Cilium Assembly
Pathways		Regulation of PLK1 Activity at G2/M Transition Loss of Nlp from mitotic centrosomes Recruitment of mitotic centrosome proteins and complexes Loss of proteins required for interphase microtubule organization from the centrosome Recruitment of NuMA to mitotic centrosomes Anchoring of the basal body to the plasma membrane AURKA Activation by TPX2
Drugs
Diseases
GWAS		Bone mineral density (hip) ( 30172743) Daytime sleep phenotypes ( 27126917) Femoral neck bone mineral density ( 30172743) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)	Allergic disease (asthma, hay fever or eczema) ( 29083406) Blood pressure measurement (low sodium intervention) ( 24165912) Gout ( 32238385) Mean corpuscular hemoglobin ( 27863252 32888494) Mean corpuscular volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Red blood cell count ( 32888494) Red cell distribution width ( 32888494) Waist circumference ( 28552196)
Interacting Genes		2 interacting genes: PIBF1 SMAD9	104 interacting genes: ALAS1 AMOTL2 ANKRD23 ANKRD28 APP ARHGAP45 ARID5A C7orf57 CARD10 CARD9 CATSPERT CBX8 CCDC13 CCDC136 CCDC138 CCHCR1 CDC37 CDK18 CEP135 CEP19 CEP63 CEP70 CFAP53 CWF19L2 DAXX DISC1 DMAP1 EFHC2 ENKD1 FAM161A FAM50B GMCL1 GOLGA2 GPKOW GRIPAP1 HAUS1 HOMEZ IGFN1 KANK2 KATNBL1 KIF9 KIFC3 KLHL2 LARP1B LMNB2 LZTS1 MAD1L1 MAP3K2 MCRS1 MDFI MFAP1 MORF4L1 MORF4L2 MTUS2 NEBL PHF1 PICK1 PKP2 PLEKHA7 POLDIP3 POU6F2 PPP1R18 PRPF18 PTPN21 RAB11FIP2 RBM11 RBM48 RNF151 RNF169 RSPH14 SCNM1 SLU7 SORBS3 SPATA18 STEEP1 SYT17 TAX1BP1 TCEA2 TFIP11 TNFAIP3 TNIP1 TNIP3 TP53BP2 TRAF2 TRAF5 TRIM27 TSGA10 TSHZ2 TSHZ3 UNC45A USP15 USP2 UTP14C XIAP ZBTB16 ZBTB4 ZC2HC1C ZFC3H1 ZFHX3 ZNF250 ZNF35 ZNF438 ZNF620 ZNF774
Entrez ID		9662	10464
HPRD ID		11097	06337
Ensembl ID		ENSG00000174799	ENSG00000083535
Uniprot IDs		Q66GS9	Q8WXW3
PDB IDs		5FCN 5NG4
Enriched GO Terms of Interacting Partners?		DNA-binding Transcription Factor Activity Transcription Regulator Complex Stem Cell Differentiation Positive Regulation Of Macromolecule Metabolic Process Heteromeric SMAD Protein Complex SMAD Protein Complex Regulation Of Glucocorticoid Biosynthetic Process Regulation Of Insulin Secretion Negative Regulation Of Dense Core Granule Biogenesis Negative Regulation Of Mesenchymal Stem Cell Differentiation Negative Regulation Of Small Molecule Metabolic Process Negative Regulation Of Amniotic Stem Cell Differentiation Regulation Of Peptide Hormone Secretion Negative Regulation Of Aldosterone Biosynthetic Process Negative Regulation Of Glucocorticoid Biosynthetic Process Negative Regulation Of Lipid Biosynthetic Process Negative Regulation Of Calcium Ion-dependent Exocytosis Regulation Of Cortisol Biosynthetic Process Regulation Of Ketone Metabolic Process Negative Regulation Of Lipid Metabolic Process Negative Regulation Of Cortisol Biosynthetic Process Regulation Of Aldosterone Biosynthetic Process Regulation Of Lipid Biosynthetic Process Negative Regulation Of Steroid Hormone Biosynthetic Process Regulation Of Mesenchymal Stem Cell Differentiation Protein Modification Process CLOCK-BMAL Transcription Complex Negative Regulation Of Nuclear Receptor-mediated Glucocorticoid Signaling Pathway Regulation Of Type B Pancreatic Cell Development Negative Regulation Of Natural Killer Cell Activation Negative Regulation Of Tyrosine Phosphorylation Of STAT Protein Interleukin-4 Receptor Binding Negative Regulation Of Prostaglandin Biosynthetic Process Activation Of Janus Kinase Activity Ubiquitin-like Protein Binding Positive Regulation Of Protein Neddylation Adult Feeding Behavior Righting Reflex Behavioral Response To Ethanol Positive Regulation Of Metabolic Process Regulation Of Hormone Secretion Cellular Response To Electrical Stimulus Regulation Of Protein Secretion Regulation Of Glucocorticoid Metabolic Process Detection Of Mechanical Stimulus Involved In Sensory Perception Of Sound Cardiac Muscle Cell Myoblast Differentiation Regulation Of Prostaglandin Biosynthetic Process Host-mediated Suppression Of Viral Transcription Cardioblast Differentiation Chromatoid Body	Protein Binding Identical Protein Binding Centrosome Cytoskeleton Nucleoplasm Spindle Pole Cytoplasm Centriole Regulation Of Innate Immune Response Regulation Of Canonical NF-kappaB Signal Transduction Nucleus Pattern Recognition Receptor Signaling Pathway Innate Immune Response-activating Signaling Pathway Positive Regulation Of Innate Immune Response Negative Regulation Of Nucleobase-containing Compound Metabolic Process Microtubule-based Process Zonula Adherens Maintenance Spliceosomal Complex Microtubule Binding Zinc Ion Binding Regulation Of Primary Metabolic Process Activation Of Innate Immune Response Regulation Of RNA Metabolic Process RNA Splicing CBM Complex Negative Regulation Of Canonical NF-kappaB Signal Transduction Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Defense Response Cell Projection Adherens Junction Maintenance Regulation Of DNA Repair NuA4 Histone Acetyltransferase Complex Regulation Of Immune Response Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Negative Regulation Of RNA Metabolic Process Regulation Of Macromolecule Metabolic Process Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway
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