FOXE1 and PLCB3

Number of citations of the paper that reports this interaction (PMID 10748198)
22

Data Source:
HPRD (in vitro)

		FOXE1	PLCB3
Gene Name		forkhead box E1	phospholipase C, beta 3 (phosphatidylinositol-specific)
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus	Nucleoplasm Cytosol Membrane Protein Complex
	Molecular Function	Sequence-specific DNA Binding RNA Polymerase II Transcription Factor Activity DNA Binding Sequence-specific DNA Binding Transcription Factor Activity Sequence-specific DNA Binding	Phosphatidylinositol Phospholipase C Activity Phospholipase C Activity Signal Transducer Activity Calcium Ion Binding Calmodulin Binding
	Biological Process	Negative Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Transcription From RNA Polymerase II Promoter Transcription From RNA Polymerase II Promoter Thyroid Hormone Generation Anatomical Structure Morphogenesis Cell Migration Thyroid Gland Development Hair Follicle Morphogenesis Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Thymus Development Embryonic Organ Morphogenesis Hard Palate Development Soft Palate Development Pharynx Development	Regulation Of Systemic Arterial Blood Pressure Synaptic Transmission Lipid Catabolic Process Intracellular Signal Transduction Inositol Phosphate Metabolic Process Small Molecule Metabolic Process
Pathways			G alpha (q) signalling events Signaling by GPCR Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion Integration of energy metabolism G beta:gamma signalling through PLC beta Signaling by Wnt Synthesis of IP3 and IP4 in the cytosol Gastrin-CREB signalling pathway via PKC and MAPK Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell PLC beta mediated events G-protein beta:gamma signalling Opioid Signalling Regulation of insulin secretion G-protein mediated events Activation of Kainate Receptors upon glutamate binding Inositol phosphate metabolism beta-catenin independent WNT signaling Presynaptic function of Kainate receptors G alpha (q) signalling events GPCR downstream signaling Acetylcholine regulates insulin secretion Ca2+ pathway Free fatty acids regulate insulin secretion Transmission across Chemical Synapses
Drugs
Diseases
GWAS		Hypothyroidism ( 21981779 22493691) Obesity-related traits ( 23251661) Thyroid cancer ( 19198613) Thyroid cancer (Papillary, radiation-related) ( 20350937) Thyroid hormone levels ( 23408906)
Protein-Protein Interactions		1 interactors: PLCB3	13 interactors: CALM3 CAMK2B CAMK2G FOXE1 KRIT1 PARD3 PARD6A PRKG1 PRKG2 RGS12 SLC9A3R2 TRPC3 TRPM7
Entrez ID		2304	5331
HPRD ID		04014	02577
Ensembl ID		ENSG00000178919	ENSG00000149782
Uniprot IDs		O00358	Q01970
PDB IDs			3OHM 4GNK
Enriched GO Terms of Interacting Partners?			Regulation Of Calcium Ion Transport Protein Autophosphorylation Regulation Of Skeletal Muscle Adaptation Wound Healing Calcium Ion Transport Response To Wounding Signal Transduction Negative Regulation Of Peptidyl-threonine Phosphorylation Blood Coagulation Hemostasis Signaling Cell Communication Nitric Oxide Metabolic Process Regulation Of G-protein Coupled Receptor Protein Signaling Pathway Regulation Of Cellular Response To Heat Reactive Nitrogen Species Metabolic Process Regulation Of Nitric-oxide Synthase Activity Regulation Of Body Fluid Levels Phosphorylation Regulation Of Ion Transport Tight Junction Assembly Cellular Response To Stimulus Protein Phosphorylation System Development Inhibitory G-protein Coupled Receptor Phosphorylation Cellular Response To Heat Response To Metal Ion Nervous System Development Apical Junction Assembly Regulation Of Oxidoreductase Activity Metal Ion Transport Regulation Of Calcium Ion Transport Into Cytosol Response To Stress Pharynx Development Activation Of Meiosis Involved In Egg Activation Positive Regulation Of Calcium Ion Transport Multicellular Organismal Development Phototransduction Response To Organic Substance Negative Regulation Of G-protein Coupled Receptor Protein Signaling Pathway Anatomical Structure Development Detection Of Light Stimulus Response To Heat Reactive Oxygen Species Metabolic Process Regulation Of Cellular Process Response To Calcium Ion Peptidyl-serine Phosphorylation Cell-cell Junction Assembly Response To Inorganic Substance Interferon-gamma-mediated Signaling Pathway
Tagcloud ?		anomalies cleft clefts cnv cnvs comprise disrupting doi etiology fgf8 gli2 grouped highlighting irf6 jhg journal kif7 lip mentioned msx1 msx2 ofc ofcs orofacial palate postulated satb2 ski tceb3	calpain candidate candidates capn1 chuk compelling consideration defect disorder distally encode fatal harlequin hi ichq ichthyosis ikka keratinocytes locus mapping mutational narrowed phospholipase r433p refined rela scaling similarities unrelated
Tagcloud (Difference) ?		anomalies cleft clefts cnv cnvs comprise disrupting doi etiology fgf8 gli2 grouped highlighting irf6 jhg journal kif7 lip mentioned msx1 msx2 ofc ofcs orofacial palate postulated satb2 ski tceb3	calpain candidate candidates capn1 chuk compelling consideration defect disorder distally encode fatal harlequin hi ichq ichthyosis ikka keratinocytes locus mapping mutational narrowed phospholipase r433p refined rela scaling similarities unrelated
Tagcloud (Intersection) ?