FAIM2 and FAS

Number of citations: 51 (PubMedID 10535980)
Data Source: HPRD (in vivo)

		FAIM2	FAS
Name		Fas apoptotic inhibitory molecule 2	Fas cell surface death receptor
Structure		No pdb structure
GO Annotations	Cellular Component	Golgi Membrane Endoplasmic Reticulum Golgi Apparatus Plasma Membrane Membrane Membrane Raft Synapse Postsynaptic Membrane	Extracellular Region Cytosol Plasma Membrane External Side Of Plasma Membrane Cell Surface Membrane Nuclear Body Death-inducing Signaling Complex CD95 Death-inducing Signaling Complex Membrane Raft Extracellular Exosome
	Molecular Function	Calcium Channel Activity Protein Binding	Transmembrane Signaling Receptor Activity Tumor Necrosis Factor Receptor Activity Protein Binding Calmodulin Binding Kinase Binding Signaling Receptor Activity Identical Protein Binding
	Biological Process	Response To Ischemia Apoptotic Process Cerebellum Development Cerebellar Purkinje Cell Layer Development Cerebellar Granular Layer Development Cerebellar Purkinje Cell Differentiation Negative Regulation Of Apoptotic Process Regulation Of Neuron Apoptotic Process Negative Regulation Of Neuron Apoptotic Process Neuron Apoptotic Process Calcium Ion Transmembrane Transport Apoptotic Signaling Pathway Negative Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Negative Regulation Of Apoptotic Signaling Pathway	Apoptotic Process Activation-induced Cell Death Of T Cells Immune Response Signal Transduction Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Regulation Of Stress-activated MAPK Cascade Tumor Necrosis Factor-mediated Signaling Pathway Cellular Response To Amino Acid Starvation Fas Signaling Pathway Regulation Of Apoptotic Process Positive Regulation Of Apoptotic Process Negative Regulation Of Apoptotic Process Protein-containing Complex Assembly Cellular Response To Mechanical Stimulus Cellular Response To Hyperoxia Motor Neuron Apoptotic Process Extrinsic Apoptotic Signaling Pathway Necroptotic Signaling Pathway Positive Regulation Of Reactive Oxygen Species Biosynthetic Process Positive Regulation Of Apoptotic Signaling Pathway
Pathways		None	Caspase activation via Death Receptors in the presence of ligand Regulation by c-FLIP RIPK1-mediated regulated necrosis CASP8 activity is inhibited TP53 Regulates Transcription of Death Receptors and Ligands Dimerization of procaspase-8 FasL/ CD95L signaling
Diseases		None	Esophageal cancer Chronic lymphocytic leukemia (CLL) Hodgkin lymphoma Adult T-cell leukemia
GWAS		Adult body size ( 32376654 ) Alcohol consumption (drinks per week) ( 30643258 ) Blood urea nitrogen levels ( 31152163 ) BMI (adjusted for smoking behaviour) ( 28443625 ) BMI in non-smokers ( 28443625 ) BMI in smokers ( 28443625 ) Body fat mass ( 28552196 ) Body mass index ( 19079260 28892062 28552196 28448500 20935630 ) Body mass index (joint analysis main effects and physical activity interaction) ( 28448500 ) Body mass index (joint analysis main effects and smoking interaction) ( 28443625 ) Body mass index in physically active individuals ( 28448500 ) Body mass index in physically inactive individuals ( 28448500 ) Body size at age 10 ( 32376654 ) Breast size ( 27182965 ) Childhood body mass index ( 26604143 ) Hip circumference ( 25673412 28552196 ) Menarche (age at onset) ( 27182965 ) Obese vs. thin ( 30677029 ) Obesity (extreme) ( 30677029 ) Obsessive-compulsive disorder ( 22889921 ) Trunk fat mass ( 28552196 ) Type 2 diabetes ( 32499647 ) Urate levels ( 31578528 ) Waist circumference ( 28552196 19557197 ) Weight ( 28552196 19079260 )	Ankylosing spondylitis ( 30946743 ) Atrioventricular conduction ( 21041692 ) Blood protein levels ( 30072576 ) Blood protein levels in cardiovascular risk ( 28369058 ) Chronic lymphocytic leukemia ( 23770605 24292274 26956414 28165464 ) Immunoglobulin A ( 20694011 ) Juvenile idiopathic arthritis (oligoarticular or rheumatoid factor-negative polyarticular) ( 23603761 ) Mean corpuscular volume ( 32888494 ) Mean spheric corpuscular volume ( 32888494 ) Mosquito bite size ( 28199695 ) Obesity-related traits ( 23251661 ) Red blood cell count ( 32888494 ) Selective IgA deficiency ( 27723758 )
Novel Interactors		2 novel interactors: ERBB2 OS9	None recorded
Interacting Genes		5 interacting genes: EPN2 FAS GGT6 SLC22A2 STK11	50 interacting genes: ANK3 APAF1 APOA5 ATP6V0B BAG6 BTK CALM1 CASP8 CASP8AP2 CCND3 CD47 CRMP1 DAXX DNAJC5 EEF1A1 EGFR ERG28 EZR FADD FAF1 FAF2 FAIM2 FASLG FBF1 FEM1B FYN GADD45A HIPK3 HNRNPC LCK LRIF1 MBD4 MET PDCD6 PRKCA PTPN13 PTPN6 RAP1A RIPK1 SUMO1 TCAP TMX1 TNFSF13 TRADD TRAF3 TRIP6 UBA7 UBAC1 UBE2I UBQLN1
Entrez ID		23017	355
HPRD ID		09184	00609
Ensembl ID		ENSG00000135472	ENSG00000026103
Uniprot IDs		Q9BWQ8	A0A8Q3SIR6 K9J972 P25445 Q59FU8
PDB IDs		Not available	1DDF 2NA7 3EWT 3EZQ 3THM 3TJE
GO Terms Enriched among Interactors		Transmembrane Signaling Receptor Activity Positive Regulation Of Signal Transduction Positive Regulation Of Cell Communication Necroptotic Signaling Pathway Death-inducing Signaling Complex Activation-induced Cell Death Of T Cells Tumor Necrosis Factor Receptor Activity CD95 Death-inducing Signaling Complex Positive Regulation Of Signaling Cellular Response To Hyperoxia Fas Signaling Pathway Negative Regulation Of Immature T Cell Proliferation In Thymus Regulation Of Microtubule-based Process RNA Polymerase I Core Binding Positive Regulation Of Kinase Activity Regulation Of Protein Kinase Activity Negative Regulation Of Developmental Process Positive Regulation Of Protein Kinase Activity Negative Regulation Of T Cell Differentiation In Thymus Negative Regulation Of Immature T Cell Proliferation ErbB-3 Class Receptor Binding ERBB3:ERBB2 Complex Regulation Of Cellular Localization Regulation Of Anatomical Structure Morphogenesis Basal Plasma Membrane Positive Regulation Of Phosphorylation Regulation Of Immature T Cell Proliferation In Thymus ERBB2-ERBB3 Signaling Pathway Regulation Of Kinase Activity ERBB3 Signaling Pathway Immature T Cell Proliferation In Thymus ERBB2-EGFR Signaling Pathway ERBB2-ERBB4 Signaling Pathway Regulation Of Protein Localization ERBB4 Signaling Pathway Positive Regulation Of Protein Phosphorylation Basolateral Plasma Membrane Serotonin Uptake Acetylcholine Transport Histamine Uptake Pyrimidine Nucleoside Transmembrane Transporter Activity Organic Cation Transmembrane Transporter Activity Azole Transmembrane Transport Choline Transport Norepinephrine Uptake Prostaglandin Transmembrane Transporter Activity Xenobiotic Transport Across Blood-brain Barrier Spermidine Transport Efflux Transmembrane Transporter Activity Toxin Transmembrane Transporter Activity	Cell Death Regulation Of Programmed Cell Death Apoptotic Process Programmed Cell Death Regulation Of Apoptotic Process Apoptotic Signaling Pathway Death Receptor Binding Regulation Of Intracellular Signal Transduction Regulation Of Signal Transduction Death-inducing Signaling Complex Regulation Of Protein Metabolic Process Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Cytosol Regulation Of Cell Communication Cytoplasm Regulation Of Signaling Tumor Necrosis Factor Receptor Binding Extrinsic Apoptotic Signaling Pathway Cell Surface Receptor Signaling Pathway Regulation Of Metabolic Process Positive Regulation Of Macrophage Differentiation Signal Transduction Regulation Of Macromolecule Metabolic Process Regulation Of Apoptotic Signaling Pathway Ubiquitin Protein Ligase Binding Positive Regulation Of Cell Communication Positive Regulation Of Signal Transduction Regulation Of Canonical NF-kappaB Signal Transduction Regulation Of Extrinsic Apoptotic Signaling Pathway Ripoptosome CD95 Death-inducing Signaling Complex Positive Regulation Of Intracellular Signal Transduction Kinase Binding Regulation Of Macrophage Differentiation Regulation Of Primary Metabolic Process Negative Regulation Of Transporter Activity Identical Protein Binding Regulation Of Protein Catabolic Process Positive Regulation Of Signaling Response To Mechanical Stimulus Necroptotic Signaling Pathway TRAIL-activated Apoptotic Signaling Pathway Protein Tyrosine Kinase Activity Regulation Of Multicellular Organismal Process Regulation Of Immune Response Positive Regulation Of Protein Metabolic Process Protein-macromolecule Adaptor Activity Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Phospholipase Activator Activity