FAIM2

Description		Fas apoptotic inhibitory molecule 2
Image		No pdb structure
GO Annotations	Cellular Component	Golgi Membrane Endoplasmic Reticulum Golgi Apparatus Plasma Membrane Membrane Membrane Raft Synapse Postsynaptic Membrane
	Molecular Function	Calcium Channel Activity Protein Binding
	Biological Process	Response To Ischemia Apoptotic Process Cerebellum Development Cerebellar Purkinje Cell Layer Development Cerebellar Granular Layer Development Cerebellar Purkinje Cell Differentiation Negative Regulation Of Apoptotic Process Regulation Of Neuron Apoptotic Process Negative Regulation Of Neuron Apoptotic Process Neuron Apoptotic Process Calcium Ion Transmembrane Transport Apoptotic Signaling Pathway Negative Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Negative Regulation Of Apoptotic Signaling Pathway
Pathways
Drugs
Diseases
GWAS		Adult body size ( 32376654) Alcohol consumption (drinks per week) ( 30643258) Blood urea nitrogen levels ( 31152163) BMI (adjusted for smoking behaviour) ( 28443625) BMI in non-smokers ( 28443625) BMI in smokers ( 28443625) Body fat mass ( 28552196) Body mass index ( 19079260 28892062 28552196 28448500 20935630) Body mass index (joint analysis main effects and physical activity interaction) ( 28448500) Body mass index (joint analysis main effects and smoking interaction) ( 28443625) Body mass index in physically active individuals ( 28448500) Body mass index in physically inactive individuals ( 28448500) Body size at age 10 ( 32376654) Breast size ( 27182965) Childhood body mass index ( 26604143) Hip circumference ( 25673412 28552196) Menarche (age at onset) ( 27182965) Obese vs. thin ( 30677029) Obesity (extreme) ( 30677029) Obsessive-compulsive disorder ( 22889921) Trunk fat mass ( 28552196) Type 2 diabetes ( 32499647) Urate levels ( 31578528) Waist circumference ( 28552196 19557197) Weight ( 28552196 19079260)
Novel Interacting Genes		2 novel interacting genes: ERBB2 OS9
Interacting Genes		5 interacting genes: EPN2 FAS GGT6 SLC22A2 STK11
Entrez ID		23017
HPRD ID		09184
Ensembl ID		ENSG00000135472
Uniprot IDs		Q9BWQ8
PDB IDs
Enriched GO Terms of Interacting Partners?		Transmembrane Signaling Receptor Activity Positive Regulation Of Signal Transduction Positive Regulation Of Cell Communication Necroptotic Signaling Pathway Death-inducing Signaling Complex Activation-induced Cell Death Of T Cells Tumor Necrosis Factor Receptor Activity CD95 Death-inducing Signaling Complex Positive Regulation Of Signaling Cellular Response To Hyperoxia Fas Signaling Pathway Negative Regulation Of Immature T Cell Proliferation In Thymus Regulation Of Microtubule-based Process RNA Polymerase I Core Binding Positive Regulation Of Kinase Activity Regulation Of Protein Kinase Activity Negative Regulation Of Developmental Process Positive Regulation Of Protein Kinase Activity Negative Regulation Of T Cell Differentiation In Thymus Negative Regulation Of Immature T Cell Proliferation ErbB-3 Class Receptor Binding ERBB3:ERBB2 Complex Regulation Of Cellular Localization Regulation Of Anatomical Structure Morphogenesis Basal Plasma Membrane Positive Regulation Of Phosphorylation Regulation Of Immature T Cell Proliferation In Thymus ERBB2-ERBB3 Signaling Pathway Regulation Of Kinase Activity ERBB3 Signaling Pathway Immature T Cell Proliferation In Thymus ERBB2-EGFR Signaling Pathway ERBB2-ERBB4 Signaling Pathway Regulation Of Protein Localization ERBB4 Signaling Pathway Positive Regulation Of Protein Phosphorylation Basolateral Plasma Membrane Serotonin Uptake Acetylcholine Transport Histamine Uptake Pyrimidine Nucleoside Transmembrane Transporter Activity Organic Cation Transmembrane Transporter Activity Azole Transmembrane Transport Choline Transport Norepinephrine Uptake Prostaglandin Transmembrane Transporter Activity Xenobiotic Transport Across Blood-brain Barrier Spermidine Transport Efflux Transmembrane Transporter Activity Toxin Transmembrane Transporter Activity
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