AMBP and ENO1

Number of citations of the paper that reports this interaction (PubMedID 21988832)
38

Data Source:
BioGRID (two hybrid)

		AMBP	ENO1
Description		alpha-1-microglobulin/bikunin precursor	enolase 1
Image
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Nucleus Cytoplasm Mitochondrion Mitochondrial Inner Membrane Endoplasmic Reticulum Cytosol Plasma Membrane Cell Surface Membrane Extracellular Matrix Nuclear Membrane Extracellular Exosome Blood Microparticle Matrix Side Of Mitochondrial Inner Membrane	Phosphopyruvate Hydratase Complex Extracellular Space Nucleus Nuclear Outer Membrane Cytoplasm Cytosol Plasma Membrane Cell Cortex Cell Surface Membrane M Band Extracellular Exosome
	Molecular Function	Serine-type Endopeptidase Inhibitor Activity Protein Binding Antioxidant Activity Oxidoreductase Activity Oxidoreductase Activity, Acting On NAD(P)H, Heme Protein As Acceptor Calcium Channel Inhibitor Activity IgA Binding Heme Binding Carbohydrate Binding Peptidase Inhibitor Activity Chondroitin Sulfate Binding Protein Homodimerization Activity Calcium Oxalate Binding Collagen Fibril Binding	Magnesium Ion Binding RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding Transcription Corepressor Binding DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA Binding Transcription Corepressor Activity RNA Binding Phosphopyruvate Hydratase Activity Protein Binding Lyase Activity Protein Homodimerization Activity Cadherin Binding Metal Ion Binding GTPase Binding
	Biological Process	Cell Adhesion Female Pregnancy Hemoglobin Metabolic Process Protein Catabolic Process Cellular Response To Reactive Oxygen Species Heme Catabolic Process Negative Regulation Of JNK Cascade Negative Regulation Of Immune Response Cellular Oxidant Detoxification Cytochrome C Metabolic Process	Negative Regulation Of Transcription By RNA Polymerase II Gluconeogenesis Glycolytic Process Response To Virus Positive Regulation Of Plasminogen Activation Negative Regulation Of Cell Growth Negative Regulation Of DNA-templated Transcription Positive Regulation Of Muscle Contraction Canonical Glycolysis Negative Regulation Of Hypoxia-induced Intrinsic Apoptotic Signaling Pathway Positive Regulation Of ATP Biosynthetic Process
Pathways		Scavenging of heme from plasma	Glycolysis Gluconeogenesis Manipulation of host energy metabolism
Drugs			Zinc Copper Artenimol Zinc acetate Zinc chloride Zinc sulfate, unspecified form
Diseases
GWAS			Asthma ( 30929738) Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined) ( 23453885) Blood protein levels ( 30072576) Feeling tense ( 29500382) Platelet count ( 32888494) Plateletcrit ( 27863252 32888494) Tonsillectomy ( 27182965 28928442) White blood cell count ( 32888494) White blood cell count (basophil) ( 27863252)
Interacting Genes		12 interacting genes: A2M ALB COX8A DAAM1 ENO1 F2 FHL3 FN1 GRB2 PIK3CA PIK3R3 STAT3	66 interacting genes: AGTPBP1 ALDOA AMBP ARID1B BCL6 BHLHE40 BRCA1 CBX5 CHEK2 CHKA CLK1 COL14A1 CYSLTR2 DES DRC2 DUX4 FANCA FHL1 FLNC FNDC3B FXR1 FYN GLIS3 GRB2 HDAC1 HEMGN HEY2 HK2 HSP90AB1 HSPB2 ITGB1 IVNS1ABP KDM2A LIG4 LINC01554 LONRF3 MCPH1 MED13 MYOC NCOR1 OGT P4HB PAF1 PCNA PDE4B PLG PPP2R5E RXFP3 SERPING1 SET SGCG SNAPC3 SRC SUMO2 SUMO4 TCAP TEAD1 TERT TRAPPC2 TTN TUBA1A UBE3A UPF2 YWHAQ YWHAZ ZBTB44
Entrez ID		259	2023
HPRD ID		01467	01400
Ensembl ID		ENSG00000106927	ENSG00000074800
Uniprot IDs		P02760	A0A024R4F1 A0A2R8Y6G6 P06733
PDB IDs		1BIK 3QKG 4ES7 4U30 6EJ7 6EJ8 6EJ9 6EJA 6EJB 6EJC 6EJD	2PSN 3B97 5JLZ 5LAX 5NI9 5NIG 5OCK 8TRL
Enriched GO Terms of Interacting Partners?		Blood Microparticle Regulation Of Growth Acute-phase Response Platelet Alpha Granule Lumen Acute Inflammatory Response Phosphatidylinositol 3-kinase Complex Phosphatidylinositol 3-kinase Complex, Class IA Insulin Receptor Signaling Pathway 1-phosphatidylinositol-3-kinase Activity Positive Regulation Of ATP Biosynthetic Process Endothelial Cell Migration Insulin Receptor Substrate Binding Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Regulation Of ATP Biosynthetic Process Negative Regulation Of Anoikis Actin Cytoskeleton Organization Phosphatidylinositol-3-phosphate Biosynthetic Process Regulation Of Cellular Response To Hypoxia Regulation Of Reactive Oxygen Species Metabolic Process Signaling Receptor Binding Regulation Of Cell Growth Regulation Of Anoikis Actin Filament-based Process Positive Regulation Of Cell Growth Cell Surface Receptor Signaling Pathway Insulin-like Growth Factor Receptor Signaling Pathway Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Positive Regulation Of ATP Metabolic Process Biological Process Involved In Interaction With Symbiont Endodermal Cell Differentiation Response To Wounding Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Negative Regulation Of Cytokine Production Involved In Inflammatory Response Phosphotyrosine Residue Binding Phosphatidylinositol Phosphate Biosynthetic Process Guanyl-nucleotide Exchange Factor Adaptor Activity Positive Regulation Of Growth Regulation Of Cellular Component Organization Negative Regulation Of Gene Expression Epidermal Growth Factor Receptor Signaling Pathway Negative Regulation Of Defense Response Positive Regulation Of Reactive Oxygen Species Metabolic Process Cell Activation Platelet Activation Enzyme-linked Receptor Protein Signaling Pathway Regulation Of Multicellular Organism Growth Negative Regulation Of Complement Activation, Lectin Pathway Enterobactin Binding Exogenous Protein Binding Endoplasmic Reticulum Lumen	Transmembrane Transporter Binding Nucleus Negative Regulation Of RNA Metabolic Process Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Intracellular Signal Transduction Animal Organ Development Organelle Organization Negative Regulation Of Immune Response Muscle Hypertrophy Developmental Process Negative Regulation Of Apoptotic Process Cytoskeletal Protein Binding Negative Regulation Of Programmed Cell Death Z Disc Titin-telethonin Complex Sarcomerogenesis Negative Regulation Of Transcription By RNA Polymerase II Muscle Structure Development Sarcomere Organization Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Signal Transduction Costamere Negative Regulation Of Macromolecule Metabolic Process Cellular Response To Stress Negative Regulation Of Metabolic Process T Cell Costimulation Identical Protein Binding Negative Regulation Of Biosynthetic Process Regulation Of Membrane Depolarization Regulation Of Metabolic Process Regulation Of Programmed Cell Death Skeletal Muscle Myosin Thick Filament Assembly Negative Regulation Of Cell Communication Negative Regulation Of Signaling Response To L-glutamate Regulation Of Gene Expression Rhythmic Process Sarcolemma Negative Regulation Of Rho Protein Signal Transduction Regulation Of DNA-templated Transcription Actomyosin Structure Organization Cellular Response To Platelet-derived Growth Factor Stimulus Regulation Of RNA Biosynthetic Process Myosin Filament Assembly Regulation Of Macromolecule Metabolic Process Regulation Of Macromolecule Biosynthetic Process Tubulin Binding Cytoskeleton Organization
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