AMBP and PIK3R3

Number of citations of the paper that reports this interaction (PMID 18624398)
4

Data Source:
BioGRID (two hybrid)

		AMBP	PIK3R3
Gene Name		alpha-1-microglobulin/bikunin precursor	phosphoinositide-3-kinase, regulatory subunit 3 (gamma)
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Region Extracellular Space Plasma Membrane Cell Surface Intracellular Membrane-bounded Organelle Extracellular Vesicular Exosome Blood Microparticle	Cytosol Phosphatidylinositol 3-kinase Complex
	Molecular Function	Serine-type Endopeptidase Inhibitor Activity Protein Binding Calcium Channel Inhibitor Activity IgA Binding Heme Binding Small Molecule Binding Protein Homodimerization Activity Calcium Oxalate Binding	Protein Binding 1-phosphatidylinositol-3-kinase Activity Phosphatidylinositol 3-kinase Regulator Activity
	Biological Process	Receptor-mediated Endocytosis Cell Adhesion Female Pregnancy Negative Regulation Of Endopeptidase Activity Viral Process Protein-chromophore Linkage Protein Catabolic Process Heme Catabolic Process Negative Regulation Of JNK Cascade Negative Regulation Of Immune Response	Phospholipid Metabolic Process Phosphatidylinositol Biosynthetic Process Insulin Receptor Signaling Pathway Phosphatidylinositol-3-phosphate Biosynthetic Process Regulation Of Phosphatidylinositol 3-kinase Activity Small Molecule Metabolic Process
Pathways		Scavenging of heme from plasma	Signaling by the B Cell Receptor (BCR) Signaling by GPCR Metabolism of lipids and lipoproteins Signaling by FGFR in disease Signaling by EGFRvIII in Cancer Signaling by SCF-KIT Downstream signaling events of B Cell Receptor (BCR) DAP12 signaling PI3K/AKT activation Interleukin receptor SHC signaling PI-3K cascade Gastrin-CREB signalling pathway via PKC and MAPK Interleukin-7 signaling Phospholipid metabolism Signaling by PDGF DAP12 interactions GAB1 signalosome G-protein beta:gamma signalling CD28 co-stimulation CD28 dependent PI3K/Akt signaling Signaling by ERBB4 Role of LAT2/NTAL/LAB on calcium mobilization Constitutive PI3K/AKT Signaling in Cancer PI3K events in ERBB4 signaling Signaling by ERBB2 G alpha (q) signalling events Signaling by EGFR Signaling by Interleukins GPCR downstream signaling Downstream signal transduction Fc epsilon receptor (FCERI) signaling Signaling by EGFR in Cancer Interleukin-2 signaling PI3K/AKT Signaling in Cancer Platelet activation, signaling and aggregation Interleukin-3, 5 and GM-CSF signaling Adaptive Immune System G alpha (q) signalling events Costimulation by the CD28 family PIP3 activates AKT signaling Synthesis of PIPs at the plasma membrane G beta:gamma signalling through PI3Kgamma PI3K events in ERBB2 signaling Regulation of signaling by CBL Downstream signaling of activated FGFR G alpha (12/13) signalling events PI Metabolism Innate Immune System Signalling by NGF Cytokine Signaling in Immune system Signaling by Ligand-Responsive EGFR Variants in Cancer NGF signalling via TRKA from the plasma membrane Signaling by Overexpressed Wild-Type EGFR in Cancer Signaling by FGFR GPVI-mediated activation cascade Interleukin receptor SHC signaling
Drugs		Human Serum Albumin Serum albumin iodonated
Diseases
GWAS
Protein-Protein Interactions		12 interactors: A2M ALB COX8A DAAM1 ENO1 F2 FHL3 FN1 GRB2 PIK3CA PIK3R3 STAT3	38 interactors: ABCB6 AMBP AXL DARS DRAP1 DSN1 EGFR ERBB2 ERBB3 ESR1 FBN3 FGB FSD2 GC IGF1R INSR IRS1 IRS2 KARS KHDRBS1 KIAA1377 KLC2 L3MBTL3 LUC7L2 MBIP MICAL1 ORM1 PDGFRB PIK3CA PSME1 QARS RB1 RING1 SERF1A TEC TRIM54 TRMT2A VBP1
Entrez ID		259	8503
HPRD ID		01467	05831
Ensembl ID		ENSG00000106927	ENSG00000117461
Uniprot IDs		P02760	F6TDL0 Q8N381 Q92569
PDB IDs		1BIK 3QKG 4ES7
Enriched GO Terms of Interacting Partners?		Platelet Activation Blood Coagulation Hemostasis Regulation Of Body Fluid Levels Wound Healing Cell Activation Response To Wounding Acute-phase Response Leukocyte Migration Platelet Degranulation Acute Inflammatory Response Regulation Of Growth Cellular Response To Peptide Hormone Stimulus Cellular Response To Peptide Blood Coagulation, Intrinsic Pathway Phosphatidylinositol-3-phosphate Biosynthetic Process Insulin Receptor Signaling Pathway Response To Peptide Hormone Cellular Response To Organonitrogen Compound Response To Peptide Neurotrophin TRK Receptor Signaling Pathway Cellular Response To Insulin Stimulus Cellular Response To Hormone Stimulus Neurotrophin Signaling Pathway Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Defense Response Regulation Of Developmental Growth Response To Insulin Vesicle-mediated Transport Movement Of Cell Or Subcellular Component Response To Stress Positive Regulation Of Phospholipase C-activating G-protein Coupled Receptor Signaling Pathway Response To Organonitrogen Compound Exocytosis Cell Migration Regulation Of Cell Growth T Cell Costimulation Enzyme Linked Receptor Protein Signaling Pathway Cell Motility Phosphatidylinositol Phosphorylation Positive Regulation Of Reactive Oxygen Species Metabolic Process Lipid Phosphorylation Response To Hormone Extracellular Matrix Disassembly Hypomethylation Of CpG Island Maintenance Of Mitochondrion Location Negative Regulation Of Complement Activation, Lectin Pathway Regulation Of Multicellular Organism Growth Inflammatory Response Anatomical Structure Formation Involved In Morphogenesis	Phosphatidylinositol-mediated Signaling Regulation Of Phosphorylation Regulation Of Kinase Activity Regulation Of Phosphorus Metabolic Process Fc-epsilon Receptor Signaling Pathway Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Fibroblast Growth Factor Receptor Signaling Pathway Fc Receptor Signaling Pathway Peptidyl-tyrosine Phosphorylation Cellular Response To Fibroblast Growth Factor Stimulus Response To Fibroblast Growth Factor Innate Immune Response Immune System Process Cellular Response To Organic Substance Neurotrophin TRK Receptor Signaling Pathway Neurotrophin Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway Phosphatidylinositol 3-kinase Signaling Regulation Of Cellular Protein Metabolic Process Negative Regulation Of Apoptotic Process Negative Regulation Of Programmed Cell Death Immune Response-regulating Cell Surface Receptor Signaling Pathway Response To Hormone Regulation Of Protein Kinase Activity Regulation Of Catalytic Activity Negative Regulation Of Cell Death Cellular Response To Hormone Stimulus Positive Regulation Of Signal Transduction Wound Healing Positive Regulation Of Cell Cycle Regulation Of Protein Metabolic Process Immune Response Regulation Of Immune System Process Regulation Of MAPK Cascade Positive Regulation Of Cellular Metabolic Process Regulation Of Protein Phosphorylation Defense Response Organ Development Negative Regulation Of Signal Transduction Immune Response-regulating Signaling Pathway Positive Regulation Of Mitotic Nuclear Division Regulation Of Signaling Response To Wounding Protein Autophosphorylation Regulation Of Apoptotic Process Regulation Of Signal Transduction Negative Regulation Of Signaling Peptidyl-amino Acid Modification
Tagcloud ?		2nh2 2oh amide aminomethylenebisphosphonate atom azido bisphosphonate bisphosphonates ch2 competitively constructing differing hydrolytic hydrophilic inorganic labelling nc nh2 photoactivatable photoaffinity po3 pocket ppase ppases ppi proton pumping pyrophosphatases vacuoles	akt carcinogenesis diagnostic downregulated elucidating hcc hepatocellular insights invasion inversely investigations lead malignancy markedly micrornas migration mir mirnas mtor negatively phosphoinositide regulating repressing strategies suppressed suppression taken tissues underlying
Tagcloud (Difference) ?		2nh2 2oh amide aminomethylenebisphosphonate atom azido bisphosphonate bisphosphonates ch2 competitively constructing differing hydrolytic hydrophilic inorganic labelling nc nh2 photoactivatable photoaffinity po3 pocket ppase ppases ppi proton pumping pyrophosphatases vacuoles	akt carcinogenesis diagnostic downregulated elucidating hcc hepatocellular insights invasion inversely investigations lead malignancy markedly micrornas migration mir mirnas mtor negatively phosphoinositide regulating repressing strategies suppressed suppression taken tissues underlying
Tagcloud (Intersection) ?