AMBP

Name	alpha-1-microglobulin/bikunin precursor
Structure
Novel Interactors	1 novel interactors: EXOSC2
Interactors	12 interactors: A2M ALB COX8A DAAM1 ENO1 F2 FHL3 FN1 GRB2 PIK3CA PIK3R3 STAT3
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Nucleus Cytoplasm Mitochondrion Mitochondrial Inner Membrane Endoplasmic Reticulum Cytosol Plasma Membrane Cell Surface Membrane Extracellular Matrix Nuclear Membrane Extracellular Exosome Blood Microparticle Matrix Side Of Mitochondrial Inner Membrane
	Molecular Function	Serine-type Endopeptidase Inhibitor Activity Protein Binding Antioxidant Activity Oxidoreductase Activity Oxidoreductase Activity, Acting On NAD(P)H, Heme Protein As Acceptor Calcium Channel Inhibitor Activity IgA Binding Heme Binding Carbohydrate Binding Peptidase Inhibitor Activity Chondroitin Sulfate Binding Protein Homodimerization Activity Calcium Oxalate Binding Collagen Fibril Binding
	Biological Process	Cell Adhesion Female Pregnancy Hemoglobin Metabolic Process Protein Catabolic Process Cellular Response To Reactive Oxygen Species Heme Catabolic Process Negative Regulation Of JNK Cascade Negative Regulation Of Immune Response Cellular Oxidant Detoxification Cytochrome C Metabolic Process
Pathways	Scavenging of heme from plasma
GWAS	No GWAS studies recorded
Entrez ID	259
HPRD ID	01467
Ensembl ID	ENSG00000106927
Uniprot IDs	P02760
PDB IDs	1BIK 3QKG 4ES7 4U30 6EJ7 6EJ8 6EJ9 6EJA 6EJB 6EJC 6EJD
GO Terms Enriched among Interactors ?	Blood Microparticle Regulation Of Growth Acute-phase Response Platelet Alpha Granule Lumen Acute Inflammatory Response Phosphatidylinositol 3-kinase Complex Phosphatidylinositol 3-kinase Complex, Class IA Insulin Receptor Signaling Pathway 1-phosphatidylinositol-3-kinase Activity Positive Regulation Of ATP Biosynthetic Process Endothelial Cell Migration Insulin Receptor Substrate Binding Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Regulation Of ATP Biosynthetic Process Negative Regulation Of Anoikis Actin Cytoskeleton Organization Phosphatidylinositol-3-phosphate Biosynthetic Process Regulation Of Cellular Response To Hypoxia Regulation Of Reactive Oxygen Species Metabolic Process Signaling Receptor Binding Regulation Of Cell Growth Regulation Of Anoikis Actin Filament-based Process Positive Regulation Of Cell Growth Cell Surface Receptor Signaling Pathway Insulin-like Growth Factor Receptor Signaling Pathway Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Positive Regulation Of ATP Metabolic Process Biological Process Involved In Interaction With Symbiont Endodermal Cell Differentiation Response To Wounding Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Negative Regulation Of Cytokine Production Involved In Inflammatory Response Phosphotyrosine Residue Binding Phosphatidylinositol Phosphate Biosynthetic Process Guanyl-nucleotide Exchange Factor Adaptor Activity Positive Regulation Of Growth Regulation Of Cellular Component Organization Negative Regulation Of Gene Expression Epidermal Growth Factor Receptor Signaling Pathway Negative Regulation Of Defense Response Positive Regulation Of Reactive Oxygen Species Metabolic Process Cell Activation Platelet Activation Enzyme-linked Receptor Protein Signaling Pathway Regulation Of Multicellular Organism Growth Negative Regulation Of Complement Activation, Lectin Pathway Enterobactin Binding Exogenous Protein Binding Endoplasmic Reticulum Lumen