FOXC1 and NPHS2

Number of citations of the paper that reports this interaction (PubMedID 24854274)
48

Data Source:
BioGRID (pull down)

		FOXC1	NPHS2
Description		forkhead box C1	NPHS2 stomatin family member, podocin
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Chromatin Heterochromatin Nucleus Nucleoplasm Cytosol	Endoplasmic Reticulum Plasma Membrane Cell-cell Junction Cytoplasmic Side Of Plasma Membrane Membrane Protein-containing Complex Slit Diaphragm Membrane Raft Extracellular Exosome Cell Periphery
	Molecular Function	Transcription Cis-regulatory Region Binding RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding DNA Binding, Bending Sequence-specific DNA Binding RNA Polymerase II-specific DNA-binding Transcription Factor Binding DNA-binding Transcription Factor Binding Promoter-specific Chromatin Binding	Protein Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Skeletal System Development Ossification Angiogenesis Ovarian Follicle Development Blood Vessel Development Eye Development Ureteric Bud Development In Utero Embryonic Development Somitogenesis Kidney Development Lymph Vessel Development Endochondral Ossification Blood Vessel Remodeling Heart Morphogenesis Apoptotic Process Involved In Outflow Tract Morphogenesis Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Notch Signaling Pathway Brain Development Heart Development Cell Population Proliferation Germ Cell Migration Anatomical Structure Morphogenesis Positive Regulation Of Gene Expression Positive Regulation Of Epithelial To Mesenchymal Transition Mesenchymal Cell Development Neural Crest Cell Development Cell Migration Negative Regulation Of Angiogenesis Cerebellum Development Cell Differentiation Collagen Fibril Organization Glycosaminoglycan Metabolic Process Lacrimal Gland Development Embryonic Heart Tube Development Maintenance Of Lens Transparency Vascular Endothelial Growth Factor Signaling Pathway Odontogenesis Of Dentin-containing Tooth Camera-type Eye Development Positive Regulation Of DNA Binding Positive Regulation Of Keratinocyte Differentiation Positive Regulation Of DNA-templated Transcription Negative Regulation Of Mitotic Cell Cycle Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Organ Growth Vascular Endothelial Growth Factor Receptor Signaling Pathway Paraxial Mesoderm Formation Mesenchymal Cell Differentiation Artery Morphogenesis Ventricular Cardiac Muscle Tissue Morphogenesis Cardiac Muscle Cell Proliferation Chemokine-mediated Signaling Pathway Cellular Response To Epidermal Growth Factor Stimulus Glomerular Epithelium Development Blood Vessel Diameter Maintenance Negative Regulation Of Lymphangiogenesis Positive Regulation Of Hematopoietic Progenitor Cell Differentiation Positive Regulation Of Hematopoietic Stem Cell Differentiation Negative Regulation Of Apoptotic Process Involved In Outflow Tract Morphogenesis Positive Regulation Of Core Promoter Binding Cellular Response To Chemokine	Glomerular Filtration Gene Expression Actin Cytoskeleton Organization Renal System Development Metanephric Podocyte Development
Pathways		Formation of intermediate mesoderm Formation of the ureteric bud	Nephrin family interactions
Drugs
Diseases		Axenfeld-Rieger syndrome (ARS)	Nephrotic syndrome and focal segmental glomerulosclerosis
GWAS		Coronary artery disease ( 29212778) Daytime sleep phenotypes ( 27126917) Essential hypertension (time to event) ( 32589924) Glaucoma ( 30054594 31959993) Glaucoma (high intraocular pressure) ( 26752265) Glaucoma (multi-trait analysis) ( 31959993) Glaucoma (primary open-angle) ( 29891935 26752265) Heel bone mineral density ( 30598549) Intraocular pressure ( 29785010 30054594 31959993) Monobrow thickness ( 26926045) Non-response to citalopram or escitalopram and depression ( 27622933) Refractive error ( 32231278) Response to platinum-based agents ( 22020760) Systolic blood pressure ( 30224653)
Interacting Genes		2 interacting genes: HMGB1 NPHS2	7 interacting genes: CD2AP FOXC1 FOXC2 KIRREL1 KIRREL3 LMX1B NPHS1
Entrez ID		2296	7827
HPRD ID		03054	05303
Ensembl ID		ENSG00000054598	ENSG00000116218
Uniprot IDs		Q12948 W6CJ52	Q9NP85
PDB IDs
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Interferon-beta Production Regulation Of Interferon-beta Production Calcium-dependent Protein Kinase Regulator Activity Regulation Of Restriction Endodeoxyribonuclease Activity Positive Regulation Of Myeloid Progenitor Cell Differentiation Regulation Of Type I Interferon Production Positive Regulation Of Type I Interferon Production Renal System Development Negative Regulation Of RNA Polymerase II Transcription Preinitiation Complex Assembly Negative Regulation Of Apoptotic Cell Clearance Metanephric Podocyte Development C-X-C Chemokine Binding Alphav-beta3 Integrin-HMGB1 Complex T-helper 1 Cell Activation Positive Regulation Of Mismatch Repair Activation Of Innate Immune Response Regulation Of Mismatch Repair Negative Regulation Of DNA-templated Transcription Initiation Positive Regulation Of Hematopoietic Progenitor Cell Differentiation Positive Regulation Of Toll-like Receptor 2 Signaling Pathway Plasmacytoid Dendritic Cell Activation Positive Regulation Of Toll-like Receptor 9 Signaling Pathway Positive Regulation Of Innate Immune Response Myeloid Progenitor Cell Differentiation Negative Regulation Of Transcription Initiation By RNA Polymerase II Regulation Of Myeloid Progenitor Cell Differentiation Positive Regulation Of Glycogen Catabolic Process Supercoiled DNA Binding Macromolecule Biosynthetic Process Positive Regulation Of Dendritic Cell Differentiation Regulation Of Endodeoxyribonuclease Activity Neutrophil Clearance Response To Thyroxine TOM Complex Mitochondrion Targeting Sequence Binding Response To L-phenylalanine Derivative DNA Geometric Change Regulation Of Glycogen Catabolic Process Bubble DNA Binding Slit Diaphragm Mitochondrial Outer Membrane Translocase Complex DNA-templated Transcription Regulation Of Apoptotic Cell Clearance Positive Regulation Of Chemokine (C-X-C Motif) Ligand 2 Production RAGE Receptor Binding Regulation Of Innate Immune Response Positive Regulation Of Defense Response Activation Of Immune Response Regulation Of Toll-like Receptor 9 Signaling Pathway DNA Topological Change	Apoptotic Process Involved In Outflow Tract Morphogenesis Negative Regulation Of Apoptotic Process Involved In Outflow Tract Morphogenesis Regulation Of Apoptotic Process Involved In Outflow Tract Morphogenesis Cell-cell Junction Apoptotic Process Involved In Heart Morphogenesis Glomerular Epithelium Development Paraxial Mesoderm Formation Renal Protein Absorption Slit Diaphragm Cell Adhesion Molecule Binding Lymph Vessel Development Endothelium Development Podocyte Differentiation Cell Junction Organization Cell-cell Adhesion Kidney Development Embryonic Heart Tube Development Apoptotic Process Involved In Morphogenesis Cell-cell Junction Organization Myosin Binding Neural Crest Cell Development Cardiac Muscle Cell Proliferation Cell Differentiation Involved In Kidney Development Apoptotic Process Involved In Development Stem Cell Development Vascular Endothelial Growth Factor Receptor Signaling Pathway Epithelium Development Extracellular Matrix Organization Tissue Development Extracellular Structure Organization Ureteric Bud Development Dendritic Shaft Blood Vessel Remodeling Regionalization Renal Absorption Cellular Developmental Process Muscle Cell Proliferation Ventricular Cardiac Muscle Tissue Morphogenesis Mesoderm Formation Somitogenesis Mesonephric Tubule Development Mesonephric Epithelium Development Positive Regulation Of Actin Filament Polymerization Segmentation Cell Adhesion Cell Development Heart Morphogenesis Cardiac Muscle Tissue Morphogenesis Formation Of Primary Germ Layer Regulation Of Actin Cytoskeleton Organization
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