MSRB2 and RAD21

Number of citations of the paper that reports this interaction (PubMedID 22145905)
0

Data Source:
BioGRID (two hybrid)

		MSRB2	RAD21
Description		methionine sulfoxide reductase B2	RAD21 cohesin complex component
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Mitochondrion Cytosol	Chromosome, Centromeric Region Chromatin Condensed Nuclear Chromosome Spindle Pole Nucleus Nucleoplasm Chromosome Cytoplasm Cytosol Cytoskeleton Cohesin Complex Membrane Nuclear Matrix Midbody Mitotic Cohesin Complex Meiotic Cohesin Complex
	Molecular Function	Actin Binding Protein Binding Zinc Ion Binding Oxidoreductase Activity Oxidoreductase Activity, Acting On A Sulfur Group Of Donors, Disulfide As Acceptor Peptide-methionine (R)-S-oxide Reductase Activity L-methionine-(R)-S-oxide Reductase Activity Metal Ion Binding	Cis-regulatory Region Sequence-specific DNA Binding DNA Binding Chromatin Binding Protein Binding LncRNA Binding DNA-binding Transcription Factor Binding
	Biological Process	Response To Oxidative Stress Actin Filament Polymerization Protein Repair	Response To Hypoxia DNA Repair Double-strand Break Repair DNA Recombination Regulation Of Transcription By RNA Polymerase II Apoptotic Process DNA Damage Response Chromosome Segregation Sister Chromatid Cohesion Reciprocal Meiotic Recombination Positive Regulation Of Gene Expression Negative Regulation Of Gene Expression Negative Regulation Of G2/M Transition Of Mitotic Cell Cycle Negative Regulation Of Interleukin-1 Beta Production Negative Regulation Of Tumor Necrosis Factor Production Positive Regulation Of Interleukin-10 Production Establishment Of Mitotic Sister Chromatid Cohesion Establishment Of Meiotic Sister Chromatid Cohesion Negative Regulation Of Glial Cell Apoptotic Process Negative Regulation Of Neuron Apoptotic Process Negative Regulation Of Mitotic Metaphase/anaphase Transition Positive Regulation Of Sister Chromatid Cohesion Cell Division Protein Localization To Chromatin Chromatin Looping Replication-born Double-strand Break Repair Via Sister Chromatid Exchange
Pathways		Protein repair	Meiotic synapsis Separation of Sister Chromatids Establishment of Sister Chromatid Cohesion Cohesin Loading onto Chromatin Resolution of Sister Chromatid Cohesion SUMOylation of DNA damage response and repair proteins Estrogen-dependent gene expression
Drugs
Diseases
GWAS		Diisocyanate-induced asthma ( 25918132) Obesity-related traits ( 23251661)	Menopause (age at onset) ( 29773799)
Interacting Genes		3 interacting genes: RAD21 TRAF2 ZDHHC17	30 interacting genes: CAPN1 CASP7 CFL1 CSTB DISC1 DYNLT1 FHL3 FLNB HNRNPH2 IL7R MSRB2 MT-CO2 NUMA1 PPP1R15A PPP1R15B PTEN RPL10 RPL13 RPL35A SMARCA5 SMC1A SSU72 STAG1 STAG2 SUMO2 TMSB4X TNFRSF14 WAPL WNT2B ZNF80
Entrez ID		22921	5885
HPRD ID		17606	05924
Ensembl ID		ENSG00000148450	ENSG00000164754
Uniprot IDs		Q9Y3D2	O60216
PDB IDs			4PJU 4PJW 4PK7 6QNX 6RRC 6RRK 6WG3 6WGE 7W1M 7ZJS 8K4D 8P0A 8PQ5 8RO6 8RO7 8RO8 8RO9 8ROA 8ROB 8ROC 8ROD 8ROE 8ROF 8ROG 8ROH 8ROI 8ROJ 8ROK 8ROL
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Glial Cell Apoptotic Process Voltage-gated Calcium Channel Activity Involved In Regulation Of Presynaptic Cytosolic Calcium Levels Membrane Depolarization During Atrial Cardiac Muscle Cell Action Potential Intracellular Protein Localization Positive Regulation Of Multicellular Organismal Process Positive Regulation Of Calcium Ion Transmembrane Transport Via High Voltage-gated Calcium Channel Voltage-gated Calcium Channel Activity Involved In AV Node Cell Action Potential Voltage-gated Calcium Channel Activity Involved In Cardiac Muscle Cell Action Potential Establishment Of Meiotic Sister Chromatid Cohesion Regulation Of Programmed Cell Death TORC2 Complex Disassembly Regulation Of Extrinsic Apoptotic Signaling Pathway TRAF2-GSTP1 Complex TORC1 Complex Assembly Regulation Of MAPK Cascade CD40 Receptor Binding Otic Placode Development Ventral Trunk Neural Crest Cell Migration Vestibulocochlear Nerve Structural Organization Renal Artery Morphogenesis VEGF-activated Neuropilin Signaling Pathway Basal Dendrite Development Basal Dendrite Arborization Trigeminal Nerve Morphogenesis Angiogenesis Involved In Coronary Vascular Morphogenesis Basal Dendrite Morphogenesis Blood Vessel Endothelial Cell Fate Specification Protein Localization To Early Endosome Facioacoustic Ganglion Development Endothelial Tip Cell Fate Specification Dorsal Root Ganglion Morphogenesis Sensory Neuron Axon Guidance Axonogenesis Postsynaptic Golgi Apparatus Regulation Of Modification Of Synapse Structure, Modulating Synaptic Transmission Perforant Pathway To Dendrate Granule Cell Synapse Negative Regulation Of Apoptotic Process Negative Regulation Of Neuron Apoptotic Process Sphingolipid Binding IRE1-TRAF2-ASK1 Complex Tumor Necrosis Factor Receptor Superfamily Complex Trigeminal Ganglion Development Sympathetic Neuron Projection Guidance Dichotomous Subdivision Of Terminal Units Involved In Salivary Gland Branching Endothelial Cell Fate Specification Vascular Endothelial Growth Factor Binding Neuropilin Signaling Pathway Receptor Complex Membrane Depolarization During AV Node Cell Action Potential Meiotic Cohesin Complex	Cohesin Complex Establishment Of Mitotic Sister Chromatid Cohesion Mitotic Cohesin Complex Establishment Of Sister Chromatid Cohesion Mitotic Spindle Pole Spindle Assembly Microtubule Cytoskeleton Organization Nuclear Matrix Microtubule Cytoskeleton Organization Involved In Mitosis Cytoskeleton Organization Chromosome Segregation Spindle Organization Cytosol Microtubule-based Process Sister Chromatid Cohesion Mitotic Spindle Assembly Negative Regulation Of Cell Size Membraneless Organelle Assembly Cell Division Establishment Of Spindle Localization Cytosolic Large Ribosomal Subunit RNA Binding Spindle Localization Chromosome, Centromeric Region Negative Regulation Of PERK-mediated Unfolded Protein Response Protein Phosphatase Type 1 Complex Regulation Of PERK-mediated Unfolded Protein Response Regulation Of Cell Size Positive Regulation Of Proteolysis Actin Binding Regulation Of Proteolysis Mitotic Spindle Organization Cytosolic Ribosome Negative Regulation Of Endoplasmic Reticulum Unfolded Protein Response Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process Ficolin-1-rich Granule Lumen Cofilin-actin Rod Negative Regulation Of Unidimensional Cell Growth Positive Regulation Of Establishment Of Cell Polarity Regulating Cell Shape Regulation Of Cellular Component Size Positive Regulation Of Barbed-end Actin Filament Capping Regulation Of Cell-matrix Adhesion Positive Regulation Of Protein Localization To Cell Leading Edge Cortical Microtubule Meiotic Cell Cycle Anastral Spindle Assembly Cytoplasmic Microtubule Bundle Positive Regulation Of Protein Localization To Spindle Pole Body Chromosome Organelle Assembly
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