BTBD3 and PLXNB3

Number of citations of the paper that reports this interaction (PubMedID 12421765)
39

Data Source:
HPRD (two hybrid)

		BTBD3	PLXNB3
Description		BTB domain containing 3	plexin B3
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol	Semaphorin Receptor Complex Plasma Membrane Cell Surface Membrane
	Molecular Function	Protein Binding Identical Protein Binding	Protein Binding Semaphorin Receptor Activity Protein Domain Specific Binding Rho GDP-dissociation Inhibitor Binding Cell-cell Adhesion Mediator Activity
	Biological Process	Nervous System Development Cerebral Cortex Development Neurogenesis Dendrite Morphogenesis	Positive Regulation Of Endothelial Cell Proliferation Homophilic Cell Adhesion Via Plasma Membrane Adhesion Molecules Negative Regulation Of Cell Adhesion Nervous System Development Synapse Assembly Regulation Of Cell Shape Negative Regulation Of Lamellipodium Assembly Positive Regulation Of Neuron Projection Development Negative Regulation Of Cell Migration Negative Regulation Of GTPase Activity Positive Regulation Of Axonogenesis Positive Chemotaxis Cell Chemotaxis Semaphorin-plexin Signaling Pathway
Pathways			Other semaphorin interactions
Drugs
Diseases
GWAS		Alanine aminotransferase levels ( 33547301) Benign prostatic hyperplasia ( 30988330) Cardiac hypertrophy ( 21348951) Cognitive decline rate in late mild cognitive impairment ( 26252872) Diastolic blood pressure ( 30224653) Hearing function ( 25060954) Intraocular pressure ( 29785010) Logical memory (delayed recall) in normal cognition ( 29274321) Logical memory (immediate recall) in normal cognition ( 29274321) Metabolite levels ( 23823483) Obesity-related traits ( 23251661) Serum metabolite levels ( 33031748) Serum metabolite ratios in chronic kidney disease ( 29545352)
Interacting Genes		10 interacting genes: BTBD6 CDC37 CUL3 GORASP2 MEOX2 PLXNB3 RNF4 SUMO1 TEPSIN UBE2I	10 interacting genes: ARHGEF11 BTBD3 CUL7 CUL9 DSCR9 HSPA13 MAGI2 MAGI3 RIT2 SPOCK2
Entrez ID		22903	5365
HPRD ID		12538	02198
Ensembl ID		ENSG00000132640	ENSG00000198753
Uniprot IDs		B4DK27 B4DRI6 Q9Y2F9	A8K920 Q9ULL4
PDB IDs
Enriched GO Terms of Interacting Partners?		Small Protein Activating Enzyme Binding PML Body Transcription Factor Binding Presynaptic Cytosol Postsynaptic Cytosol Roof Of Mouth Development Post-translational Protein Modification Nuclear Body Protein Modification By Small Protein Conjugation Protein Autoubiquitination Protein Sumoylation SUMO Conjugating Enzyme Activity Nuclear Pore Regulation Of Protein Stability Trophectodermal Cellular Morphogenesis Liver Morphogenesis HSP90-CDC37 Chaperone Complex Coated Vesicle Membrane Rho GDP-dissociation Inhibitor Binding Regulation Of Kinetochore Assembly Protein K48-linked Ubiquitination RING-like Zinc Finger Domain Binding Protein Localization To Nuclear Pore Regulation Protein Catabolic Process At Postsynapse	Cullin-RING Ubiquitin Ligase Complex
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