BAHD1 and DVL2

Number of citations of the paper that reports this interaction (PMID 16189514)
699

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		BAHD1	DVL2
Gene Name		bromo adjacent homology domain containing 1	dishevelled segment polarity protein 2
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Chromatin Nucleoplasm Chromatin Silencing Complex	Nucleus Cytoplasm Cytosol Plasma Membrane Cytoplasmic Vesicle Apical Part Of Cell Clathrin-coated Endocytic Vesicle
	Molecular Function	Transcription Regulatory Region Sequence-specific DNA Binding Chromatin Binding Protein Binding	Frizzled Binding Protein Binding Protein Domain Specific Binding Identical Protein Binding Protein Self-association
	Biological Process	Chromatin Silencing Transcription, DNA-templated Heterochromatin Assembly Negative Regulation Of Transcription, DNA-templated	Neural Tube Closure Positive Regulation Of Protein Phosphorylation Outflow Tract Morphogenesis Transcription From RNA Polymerase II Promoter Segment Specification Heart Development Wnt Signaling Pathway Convergent Extension Involved In Neural Plate Elongation Cellular Protein Localization Hippo Signaling Non-canonical Wnt Signaling Pathway Positive Regulation Of JUN Kinase Activity Canonical Wnt Signaling Pathway Involved In Regulation Of Cell Proliferation Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Canonical Wnt Signaling Pathway Wnt Signaling Pathway, Planar Cell Polarity Pathway Positive Regulation Of Protein Tyrosine Kinase Activity Negative Regulation Of Canonical Wnt Signaling Pathway Cochlea Morphogenesis Planar Cell Polarity Pathway Involved In Neural Tube Closure Positive Regulation Of Canonical Wnt Signaling Pathway
Pathways			misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling Signaling by Wnt negative regulation of TCF-dependent signaling by DVL-interacting proteins beta-catenin independent WNT signaling disassembly of the destruction complex and recruitment of AXIN to the membrane WNT mediated activation of DVL Signaling by Hippo TCF dependent signaling in response to WNT RNF mutants show enhanced WNT signaling and proliferation Asymmetric localization of PCP proteins WNT5A-dependent internalization of FZD4 XAV939 inhibits tankyrase, stabilizing AXIN degradation of DVL Signaling by WNT in cancer PCP/CE pathway
Drugs
Diseases
GWAS
Protein-Protein Interactions		20 interactors: AES BEGAIN CALCOCO2 DVL2 DVL3 GOLGA2 KDM1A KHDRBS3 KRT40 KRTAP10-1 KRTAP10-3 KRTAP10-7 KRTAP4-12 LZTS2 MDFI MEGF10 PRKAR1A SUV39H1 TRAF2 TRAF4	61 interactors: AP1M1 AP2M1 ARHGEF39 ARR3 ARRB1 ARRB2 ATN1 AXIN1 BAG3 BAHD1 CCDC33 CPSF7 CSNK1E CTBP2 DAAM1 DDI1 DPPA2 DYNLT1 ENKD1 FZD4 GABARAP GABARAPL1 ITCH LRRK2 MAP1LC3A MCRS1 OTULIN PARD6A PCBD1 PLA2G12A POLI PPM1A PRKCA PRKCB PRKCG PRPF3 RAC1 RBFOX1 RBPMS RHOA RHOXF2 RNF185 RNPS1 RUNX2 SMURF1 SNF8 SNIP1 SORBS3 TCEB3B THAP1 TIFA TP53 TRAF2 U2AF2 USP5 VANGL1 VHL ZBTB8A ZNF165 ZNF250 ZNF263
Entrez ID		22893	1856
HPRD ID		12518	03690
Ensembl ID		ENSG00000140320	ENSG00000004975
Uniprot IDs		Q8TBE0	I3L2N2 O14641
PDB IDs			2REY 3CBX 3CBY 3CBZ 3CC0
Enriched GO Terms of Interacting Partners?		Positive Regulation Of JNK Cascade Regulation Of Binding Positive Regulation Of Stress-activated MAPK Cascade Positive Regulation Of Stress-activated Protein Kinase Signaling Cascade Regulation Of Protein Binding Regulation Of JNK Cascade Regulation Of Stress-activated MAPK Cascade Negative Regulation Of Wnt Signaling Pathway Positive Regulation Of JUN Kinase Activity Regulation Of JUN Kinase Activity Positive Regulation Of Protein Kinase Activity Positive Regulation Of Kinase Activity Negative Regulation Of Binding Positive Regulation Of Protein Serine/threonine Kinase Activity Positive Regulation Of Transferase Activity Regulation Of Wnt Signaling Pathway Negative Regulation Of Canonical Wnt Signaling Pathway Positive Regulation Of Protein Phosphorylation Regulation Of Protein Kinase Activity Regulation Of Kinase Activity Positive Regulation Of MAPK Cascade Negative Regulation Of Protein Binding Positive Regulation Of MAP Kinase Activity Positive Regulation Of Phosphorylation Regulation Of Canonical Wnt Signaling Pathway Positive Regulation Of Protein Modification Process Positive Regulation Of Protein Homodimerization Activity Activation Of Protein Kinase Activity Organ Development Wnt Signaling Pathway Regulation Of Signaling Regulation Of Protein Phosphorylation Regulation Of MAPK Cascade Regulation Of MAP Kinase Activity Planar Cell Polarity Pathway Involved In Neural Tube Closure Negative Regulation Of Signal Transduction Regulation Of Establishment Of Planar Polarity Involved In Neural Tube Closure Positive Regulation Of Cellular Protein Metabolic Process Negative Regulation Of Signaling Regulation Of Embryonic Development Positive Regulation Of Protein Metabolic Process Regulation Of Protein Homodimerization Activity Activation Of NF-kappaB-inducing Kinase Activity Wnt Signaling Pathway, Planar Cell Polarity Pathway Regulation Of Phosphorylation Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Intracellular Signal Transduction Regulation Of Signal Transduction Cochlea Morphogenesis Positive Regulation Of NIK/NF-kappaB Signaling	Regulation Of Nitrogen Compound Metabolic Process Regulation Of Metabolic Process Regulation Of Gene Expression Regulation Of RNA Metabolic Process Transcription, DNA-templated RNA Biosynthetic Process Gene Expression RNA Metabolic Process Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Positive Regulation Of Signal Transduction Positive Regulation Of Intracellular Signal Transduction Cellular Response To Growth Factor Stimulus Nucleobase-containing Compound Metabolic Process Response To Growth Factor Regulation Of Signal Transduction Cellular Nitrogen Compound Metabolic Process Regulation Of Cellular Response To Growth Factor Stimulus Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Platelet Activation Cellular Metabolic Process Regulation Of Cellular Process Cell Death Death Cellular Macromolecule Biosynthetic Process Enzyme Linked Receptor Protein Signaling Pathway Cellular Response To Organic Substance Negative Regulation Of Cellular Metabolic Process Positive Regulation Of Cellular Metabolic Process Transforming Growth Factor Beta Receptor Signaling Pathway Regulation Of Signaling Negative Regulation Of Signal Transduction Macromolecule Biosynthetic Process Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Nitrogen Compound Metabolic Process Regulation Of Intracellular Signal Transduction Apoptotic Process Catabolic Process Negative Regulation Of Signaling Programmed Cell Death Regulation Of G-protein Coupled Receptor Protein Signaling Pathway Positive Regulation Of Phosphorylation Cellular Response To Transforming Growth Factor Beta Stimulus Membrane Organization Positive Regulation Of Protein Metabolic Process Viral Process Histone H3-T6 Phosphorylation Response To Transforming Growth Factor Beta
Tagcloud ?		acetyl bromo coimmunoprecipitates collectively colocalization colocalizes coordinate cpg directs ectopically h3k27me3 hdac5 heterochromatic heterochromatin heterochromatinization highlighted hp1 igf2 inactive mbd1 p3 recruiting represses silencer sp1 trimethylated vertebrates xi	adaptor ap2 ap2mu2 assembled assembles blockage clathrin clustering continuously disassembled dissolution endocytic endocytosis follows fz inhibiton internalization lrp6 maintain mu2 path rab routes signalosome take transducer transducers vertebrates wnt
Tagcloud (Difference) ?		acetyl bromo coimmunoprecipitates collectively colocalization colocalizes coordinate cpg directs ectopically h3k27me3 hdac5 heterochromatic heterochromatin heterochromatinization highlighted hp1 igf2 inactive mbd1 p3 recruiting represses silencer sp1 trimethylated xi	adaptor ap2 ap2mu2 assembled assembles blockage clathrin clustering continuously disassembled dissolution endocytic endocytosis follows fz inhibiton internalization lrp6 maintain mu2 path rab routes signalosome take transducer transducers wnt
Tagcloud (Intersection) ?		vertebrates