ZNF652 and CD200

		ZNF652	CD200
Description		zinc finger protein 652	CD200 molecule
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleus	Plasma Membrane Cell Surface Membrane Axon Neuron Projection Neuronal Cell Body Cell Body
	Molecular Function	DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA Binding Protein Binding Zinc Ion Binding Metal Ion Binding	Protein Binding Protein Binding Involved In Heterotypic Cell-cell Adhesion Cell-cell Adhesion Mediator Activity Glycosylated Region Protein Binding
	Biological Process	Regulation Of Transcription By RNA Polymerase II	Negative Regulation Of Leukocyte Activation Negative Regulation Of Cell Population Proliferation Negative Regulation Of Interleukin-6 Production Heterotypic Cell-cell Adhesion Negative Regulation Of Macrophage Activation Positive Regulation Of Macrophage Activation Negative Regulation Of Canonical NF-kappaB Signal Transduction Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Immune Response Cellular Response To Lipopolysaccharide Cellular Response To Type II Interferon Positive Regulation Of Transforming Growth Factor Beta Production Cell-cell Adhesion Regulation Of Neuroinflammatory Response Negative Regulation Of Neuroinflammatory Response Negative Regulation Of Matrix Metallopeptidase Secretion Negative Regulation Of Macrophage Migration Negative Regulation Of T Cell Migration
Pathways			Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
Drugs
Diseases
GWAS		Allergic disease (asthma, hay fever or eczema) ( 29083406) Asthma ( 34103634 29273806 32296059 31959851 30929738 31619474 31361310) Asthma (adult onset) ( 30929738) Asthma (childhood onset) ( 30929738 31036433) Asthma (moderate or severe) ( 30552067) Atopic dermatitis ( 23727859) Blood pressure ( 21909110) Body fat distribution (arm fat ratio) ( 30664634) Body fat distribution (leg fat ratio) ( 30664634) Body fat distribution (trunk fat ratio) ( 30664634) Brain morphology (MOSTest) ( 32665545) Cancer ( 29299148) Coronary artery disease ( 29212778) Diastolic blood pressure ( 27841878 27618452 27618447 28739976 19430483) Diastolic blood pressure x alcohol consumption (light vs heavy) interaction (2df test) ( 29912962) Diastolic blood pressure x alcohol consumption interaction (2df test) ( 29912962) Egg allergy (maternal genetic effects) ( 29489655) Eosinophil count ( 27863252) Eosinophil percentage of granulocytes ( 27863252) Eosinophil percentage of white cells ( 27863252) Height ( 20881960) Intraocular pressure ( 29785010) Mean arterial pressure x alcohol consumption (light vs heavy) interaction (2df test) ( 29912962) Mean arterial pressure x alcohol consumption interaction (2df test) ( 29912962) Mean reticulocyte volume ( 32888494) Multiple sclerosis ( 31604244) Myocardial infarction ( 33532862) Neutrophil percentage of granulocytes ( 27863252) Prostate cancer ( 23535732 21602798 34012061) Refractive error ( 32231278) Sex hormone-binding globulin levels ( 22829776) Systolic blood pressure ( 27841878 27618452) Systolic blood pressure x alcohol consumption interaction (2df test) ( 29912962) Thyroid stimulating hormone levels ( 32769997) Triglyceride levels ( 32203549)	Basal cell carcinoma ( 33549134) Blood protein levels ( 30072576) Cognitive decline rate in late mild cognitive impairment ( 26252872) Eosinophil count ( 27863252 32888494) Eosinophil percentage of granulocytes ( 27863252) Eosinophil percentage of white cells ( 27863252 32888494) Neutrophil percentage of granulocytes ( 27863252) Sum eosinophil basophil counts ( 27863252)
Interacting Genes		4 interacting genes: CBFA2T2 CBFA2T3 RUNX1T1 TRIM14	3 interacting genes: CD200R1 HCRTR2 HUS1
Entrez ID		22834	4345
HPRD ID		18362	01124
Ensembl ID		ENSG00000198740	ENSG00000091972
Uniprot IDs		A8K9F2 D6RF85 Q9Y2D9	B4DDZ6 F8W7G1 P41217 U3KQQ2
PDB IDs
Enriched GO Terms of Interacting Partners?		Transcription Corepressor Activity DNA-templated Transcription Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Zinc Ion Binding Glycosylated Region Protein Binding Nucleobase-containing Compound Biosynthetic Process Negative Regulation Of Macromolecule Biosynthetic Process Protein Binding Involved In Heterotypic Cell-cell Adhesion Negative Regulation Of Biosynthetic Process Regulation Of Macromolecule Biosynthetic Process Regulation Of Primary Metabolic Process Regulation Of Gene Expression Negative Regulation Of T Cell Migration Negative Regulation Of Matrix Metallopeptidase Secretion Negative Regulation Of Macromolecule Metabolic Process Regulation Of Macromolecule Metabolic Process Negative Regulation Of Metabolic Process Regulation Of Matrix Metallopeptidase Secretion Intestinal Epithelial Cell Differentiation Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Regulation Of Metabolic Process Negative Regulation Of RNA Metabolic Process Macromolecule Biosynthetic Process RNA Metabolic Process Negative Regulation Of Glycolytic Process Negative Regulation Of Lymphocyte Migration Negative Regulation Of Macrophage Migration Positive Regulation Of Transforming Growth Factor Beta Production Negative Regulation Of Macrophage Activation Negative Regulation Of Neuroinflammatory Response Negative Regulation Of Viral Transcription Regulation Of Viral Transcription Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of ATP Metabolic Process Metal Ion Binding Granulocyte Differentiation Regulation Of Aerobic Respiration Positive Regulation Of Macrophage Activation Protein K48-linked Deubiquitination
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