COPG1 and DRD1

Number of citations of the paper that reports this interaction (PMID 11893085)
4

Data Source:
HPRD (in vitro, in vivo)

		COPG1	DRD1
Gene Name		coatomer protein complex, subunit gamma 1	dopamine receptor D1
Image
Gene Ontology Annotations	Cellular Component	Golgi Membrane Cytosol COPI Vesicle Coat	Nucleus Endoplasmic Reticulum Membrane Plasma Membrane Integral Component Of Plasma Membrane
	Molecular Function	Structural Molecule Activity Protein Binding	Dopamine Neurotransmitter Receptor Activity, Coupled Via Gs Dopamine Neurotransmitter Receptor Activity Protein Binding Dopamine Binding
	Biological Process	Intracellular Protein Transport Retrograde Vesicle-mediated Transport, Golgi To ER COPI Coating Of Golgi Vesicle Establishment Of Golgi Localization Membrane Organization Organelle Transport Along Microtubule	Temperature Homeostasis Conditioned Taste Aversion Behavioral Fear Response Synaptic Transmission, Dopaminergic Response To Amphetamine Protein Import Into Nucleus G-protein Coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Adenylate Cyclase-activating G-protein Coupled Receptor Signaling Pathway Activation Of Adenylate Cyclase Activity Adenylate Cyclase-activating Dopamine Receptor Signaling Pathway Synapse Assembly Memory Mating Behavior Grooming Behavior Adult Walking Behavior Visual Learning Positive Regulation Of Adenylate Cyclase Activity Involved In G-protein Coupled Receptor Signaling Pathway Astrocyte Development Dopamine Transport Transmission Of Nerve Impulse Neuronal Action Potential Dentate Gyrus Development Striatum Development Cerebral Cortex GABAergic Interneuron Migration Positive Regulation Of Cell Migration Peristalsis Positive Regulation Of CAMP Biosynthetic Process Operant Conditioning Regulation Of Dopamine Metabolic Process Vasodilation Dopamine Metabolic Process Response To Drug Maternal Behavior Positive Regulation Of Potassium Ion Transport Glucose Import Habituation Sensitization Behavioral Response To Cocaine Positive Regulation Of Release Of Sequestered Calcium Ion Into Cytosol Positive Regulation Of Cytosolic Calcium Ion Concentration Involved In Phospholipase C-activating G-protein Coupled Signaling Pathway Regulation Of Dopamine Uptake Involved In Synaptic Transmission Positive Regulation Of Synaptic Transmission, Glutamatergic Prepulse Inhibition Phospholipase C-activating Dopamine Receptor Signaling Pathway Long-term Synaptic Potentiation Long Term Synaptic Depression Cellular Response To Catecholamine Stimulus
Pathways		COPI Mediated Transport Golgi to ER Retrograde Transport	Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) Signaling by GPCR GPCR downstream signaling G alpha (s) signalling events Class A/1 (Rhodopsin-like receptors) Amine ligand-binding receptors Metabolic disorders of biological oxidation enzymes GPCR ligand binding Dopamine receptors
Drugs		S-(Dimethylarsenic)Cysteine	Ziprasidone Cabergoline Ropinirole Olanzapine Methylergonovine Clozapine Thiethylperazine Phenylpropanolamine Loxapine Pramipexole Promazine Chlorpromazine Haloperidol Triflupromazine Amoxapine Lisuride Fluphenazine Thioridazine Apomorphine Trimipramine Risperidone Propiomazine Fenoldopam Minaprine Perphenazine Flupenthixol Dopamine Carphenazine Acetophenazine Pergolide Bromocriptine Quetiapine Levodopa Aripiprazole Chlorprothixene Paliperidone Dihydroergotoxine Methotrimeprazine Propericiazine Acepromazine Pipotiazine Thioproperazine Thiothixene Zuclopenthixol Iloperidone Rotigotine Asenapine
Diseases
GWAS			Obesity-related traits ( 23251661) Treatment response for severe sepsis ( 22310353)
Protein-Protein Interactions		15 interactors: ARCN1 ARF1 COPB1 COPE COPG2 COPZ1 COPZ2 DRD1 H2AFX PPBP PTGES3 RHOQ SACM1L TAPBP TMED10	11 interactors: ADA ADORA1 CALY CAV2 COPG1 COPG2 DNAJC14 EPB41L2 FLNA GRIN1 HRH3
Entrez ID		22820	1812
HPRD ID		09887	00538
Ensembl ID		ENSG00000181789	ENSG00000184845
Uniprot IDs		Q9Y678	P21728
PDB IDs		1R4X	1OZ5
Enriched GO Terms of Interacting Partners?		Retrograde Vesicle-mediated Transport, Golgi To ER COPI-coated Vesicle Budding COPI Coating Of Golgi Vesicle Golgi Vesicle Budding Vesicle Targeting, To, From Or Within Golgi Localization Within Membrane Vesicle Targeting Golgi Vesicle Transport Membrane Budding Vesicle-mediated Transport Establishment Of Localization In Cell Establishment Of Vesicle Localization Vesicle Organization Vesicle Localization Intracellular Transport Cellular Localization Establishment Of Organelle Localization Protein Transport Intra-Golgi Vesicle-mediated Transport Establishment Of Protein Localization Organelle Localization Protein Localization Intracellular Protein Transport Cellular Protein Localization Membrane Organization Transport Organelle Organization Long Term Synaptic Depression Cerebellar Purkinje Cell Layer Maturation Peptide Antigen Stabilization Negative Regulation Of Synaptic Transmission Glucose Transport Hexose Transport Sensitization ER To Golgi Vesicle-mediated Transport Habituation Cerebellum Maturation Adult Locomotory Behavior Phosphatidylinositol Biosynthetic Process Carbohydrate Transport Nonassociative Learning Chaperone Cofactor-dependent Protein Refolding Response To Alkaloid Operant Conditioning Conditioned Taste Aversion Positive Regulation Of Adenylate Cyclase Activity Involved In G-protein Coupled Receptor Signaling Pathway Regulation Of Adenylate Cyclase Activity Involved In G-protein Coupled Receptor Signaling Pathway Lipid Biosynthetic Process Adult Behavior Regulation Of Synaptic Plasticity	Negative Regulation Of Mucus Secretion Negative Regulation Of Circadian Sleep/wake Cycle, Non-REM Sleep Transport Negative Regulation Of Circadian Sleep/wake Cycle, Sleep Negative Regulation Of Glutamate Secretion Regulation Of Circadian Sleep/wake Cycle, Non-REM Sleep Regulation Of Glutamate Secretion Vesicle-mediated Transport Negative Regulation Of Transport Membrane Organization Regulation Of Circadian Sleep/wake Cycle, Sleep Regulation Of Mucus Secretion G-protein Coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Negative Regulation Of Circadian Rhythm Negative Regulation Of Leukocyte Migration Regulation Of Respiratory Gaseous Exchange Negative Regulation Of Secretion Vesicle Organization Dopamine Receptor Signaling Pathway Retrograde Vesicle-mediated Transport, Golgi To ER Response To Morphine Negative Regulation Of Blood Pressure Regulation Of Smooth Muscle Contraction Cognition Establishment Of Protein Localization Adenylate Cyclase-inhibiting G-protein Coupled Receptor Signaling Pathway Positive Regulation Of Intracellular Signal Transduction Negative Regulation Of Long Term Synaptic Depression Negative Regulation Of Neurotrophin Production Deoxyadenosine Catabolic Process Positive Regulation Of Nucleoside Transport Negative Regulation Of Adenosine Receptor Signaling Pathway Negative Regulation Of Penile Erection Propylene Metabolic Process Xanthine Biosynthetic Process Regulation Of Excitatory Postsynaptic Membrane Potential Regulation Of Postsynaptic Membrane Potential Membrane Budding Sensory Perception Of Pain Response To Ammonium Ion Protein Complex Assembly Negative Regulation Of Ion Transport Regulation Of Circadian Rhythm Feeding Behavior Olfactory Learning Negative Regulation Of Gamma-aminobutyric Acid Secretion Purine Deoxyribonucleoside Metabolic Process Protein Localization Negative Regulation Of Inflammatory Response Establishment Of Localization In Cell
Tagcloud ?			adrenocorticotropic appetite blair denton embodied experimentation fitzsimons gluco gratification gratified instinct instinctive instincts intricately johnson lehrman liedtke luca mineralocorticoids respected richter roitman satiation sentiment suprarenal thirst thunhorst veteran wolf
Tagcloud (Difference) ?			adrenocorticotropic appetite blair denton embodied experimentation fitzsimons gluco gratification gratified instinct instinctive instincts intricately johnson lehrman liedtke luca mineralocorticoids respected richter roitman satiation sentiment suprarenal thirst thunhorst veteran wolf
Tagcloud (Intersection) ?