H2AC1 and TLE3

Number of citations: 58 (PubMedID 28689657)
Data Source: BioGRID (unspecified method)

		H2AC1	TLE3
Name		H2A clustered histone 1	TLE family member 3, transcriptional corepressor
Structure			No pdb structure
GO Annotations	Cellular Component	Chromosome, Telomeric Region Nucleosome Female Germ Cell Nucleus Nucleus Chromosome Extracellular Exosome	Nucleus Nucleoplasm Transcription Regulator Complex Beta-catenin-TCF Complex
	Molecular Function	DNA Binding Structural Constituent Of Chromatin Protein Heterodimerization Activity	Transcription Corepressor Activity Protein Binding
	Biological Process	Chromatin Organization Heterochromatin Formation	Regulation Of DNA-templated Transcription Signal Transduction Animal Organ Morphogenesis Wnt Signaling Pathway Negative Regulation Of DNA-templated Transcription Negative Regulation Of Canonical Wnt Signaling Pathway Negative Regulation Of Cold-induced Thermogenesis
Pathways		HDACs deacetylate histones HATs acetylate histones HATs acetylate histones RMTs methylate histone arginines UCH proteinases Ub-specific processing proteases Metalloprotease DUBs HCMV Early Events HCMV Late Events	Formation of the beta-catenin:TCF transactivating complex Deactivation of the beta-catenin transactivating complex Repression of WNT target genes Repression of WNT target genes Estrogen-dependent gene expression
GWAS		No GWAS studies recorded	Alcoholic chronic pancreatitis ( 28754779 ) Atrial fibrillation ( 29892015 ) Cognitive function ( 24684796 ) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098 ) Eosinophil count ( 32888494 ) Eosinophil percentage of white cells ( 32888494 ) Heel bone mineral density ( 30598549 28869591 ) Height ( 20881960 31562340 28552196 25282103 ) Hip circumference adjusted for BMI ( 34021172 ) L-selectin levels ( 25576479 ) Lumbar spine bone mineral density (integral) ( 27476799 ) Lung adenocarcinoma ( 28604730 ) Macular thickness ( 30535121 ) Male-pattern baldness ( 27182965 ) Monocyte percentage of white cells ( 32888494 ) Non-albumin protein levels ( 29403010 ) Non-response to citalopram or escitalopram and depression ( 27622933 ) PR interval ( 32439900 30046033 ) Pulmonary function ( 23932459 ) Red blood cell count ( 32888494 ) Rheumatoid arthritis ( 23143596 ) Rheumatoid arthritis (ACPA-positive) ( 24532676 23143596 ) Schizophrenia ( 30285260 29483656 25056061 ) Serum total protein levels ( 29403010 ) Triglyceride levels ( 29403010 33339817 ) Waist circumference adjusted for BMI (joint analysis main effects and physical activity interaction) ( 28448500 ) Waist circumference adjusted for BMI in active individuals ( 28448500 ) Waist circumference adjusted for body mass index ( 28448500 34021172 ) White blood cell count ( 32888494 )
Interacting Genes		5 interacting genes: ANP32B HDAC1 HDAC2 HDAC3 TLE3	17 interacting genes: APP CHERP CSTF2 FBXO7 FOXG1 H2AC1 H3C1 H4C1 HINFP KRTAP15-1 NDRG1 NOTCH1 PIN1 SIX1 SIX3 TCF4 USP47
Entrez ID		221613	7090
HPRD ID		13653	02558
Ensembl ID		ENSG00000164508	ENSG00000140332
Uniprot IDs		Q96QV6	B3KUA2 H0YL70 Q04726 Q6PRX3
PDB IDs		5GSU 5GT0	Not available
GO Terms Enriched among Interactors		Protein Lysine Delactylase Activity Protein Decrotonylase Activity Histone Decrotonylase Activity Histone Deacetylase Activity, Hydrolytic Mechanism Protein Lysine Deacetylase Activity Histone Deacetylase Activity NF-kappaB Binding Protein De-2-hydroxyisobutyrylase Activity Histone Deacetylase Complex Fungiform Papilla Formation Circadian Regulation Of Gene Expression Hair Follicle Placode Formation Deacetylase Activity Histone Deacetylase Binding Circadian Rhythm Eyelid Development In Camera-type Eye Heterochromatin Formation Protein Deacetylation Positive Regulation Of Intracellular Estrogen Receptor Signaling Pathway Hydrolase Activity, Acting On Carbon-nitrogen (but Not Peptide) Bonds, In Linear Amides NuRD Complex Negative Regulation Of Gene Expression, Epigenetic Negative Regulation Of Myotube Differentiation Chromatin Remodeling DNA-binding Transcription Factor Binding Positive Regulation Of Oligodendrocyte Differentiation Sin3-type Complex Transcription Corepressor Activity Regulation Of Cell Fate Specification Negative Regulation Of Stem Cell Population Maintenance Macromolecule Deacylation Chromatin Organization Negative Regulation Of Apoptotic Process Rhythmic Process Negative Regulation Of Programmed Cell Death Epigenetic Regulation Of Gene Expression Negative Regulation Of Developmental Process Regulation Of Intracellular Estrogen Receptor Signaling Pathway Regulation Of Protein Export From Nucleus Positive Regulation Of Glial Cell Differentiation Nucleosomal DNA Binding Regulation Of Oligodendrocyte Differentiation Negative Regulation Of Striated Muscle Cell Differentiation Regulation Of Myotube Differentiation Regulation Of Cell Fate Commitment Positive Regulation Of Stem Cell Population Maintenance Transcription Corepressor Binding Embryonic Digit Morphogenesis Negative Regulation Of Multicellular Organismal Process Enzyme Binding	Protein Heterodimerization Activity Regulation Of Neuron Differentiation Nucleus Regulation Of Cell Cycle Regulation Of Cell Cycle Phase Transition Axon Midline Choice Point Recognition Regulation Of Neuroblast Proliferation Regulation Of Cell Cycle Process Axon Choice Point Recognition Regulation Of Mitotic Cell Cycle Regulation Of Wnt Signaling Pathway Regulation Of Cardioblast Proliferation Establishment Of Protein Localization To Organelle Mitogen-activated Protein Kinase Kinase Binding Apoptotic Process Nucleoplasm Negative Regulation Of Neuron Differentiation Cell Death Programmed Cell Death Positive Regulation Of Transcription By RNA Polymerase II Protein Targeting Structural Constituent Of Chromatin Negative Regulation Of Cell Cycle Phase Transition Positive Regulation Of Neuron Differentiation Regulation Of Neural Precursor Cell Proliferation Regulation Of Cell Proliferation Involved In Heart Morphogenesis Regulation Of Canonical Wnt Signaling Pathway Cell Morphogenesis Involved In Neuron Differentiation Notch Signaling Pathway Prostate Gland Epithelium Morphogenesis Negative Regulation Of Cell Cycle Process Epithelial Cell Maturation Nucleosome Cellular Developmental Process Regulation Of Cell Differentiation Positive Regulation Of Neuroblast Proliferation Survivin Complex Negative Regulation Of DNA-templated Transcription Negative Regulation Of Cell Cycle Regulation Of Intracellular Signal Transduction Regulation Of Cell Population Proliferation Negative Regulation Of RNA Biosynthetic Process Amyloid-beta Complex Growth Cone Lamellipodium Positive Regulation Of RNA Biosynthetic Process DNA Binding Regulation Of Response To Calcium Ion Amylin Binding Cell Maturation Positive Regulation Of Toll Signaling Pathway